The quintessence of this article encompasses the effect of diffusiophoresis, chemical reaction, and varying viscosity as well as thermal conductivity on a fully developed dissipative flow through an upright channel. The fluid is electrically conducting undergoing mixed convection. The governing equations, after transfiguring into dimensionless formation, are solved through a numerical procedure for boundary value problems incorporating MATLAB solver. Imperative scrutiny is made to visualize associative impacts of flow parameters, namely, magnetic parameter, the Brinkmann number, the Schmidt number, variable viscosity parameter, variable thermal conductivity parameter, chemical reaction parameter, diffusiophoretic parameter, and particle diffusion parameter, on the flow. The velocity field, the temperature field, the solute concentration field, the particle concentration field, the skin friction, the Nusselt number, the Sherwood number, and the particle concentration gradient are assessed in view of alteration of the aforesaid parameters with the help of visual illustrations in graphical form and tabular form. Solute mass transposition and colloidal particle locomotion are the fresh inclusions to the scrutiny of upright channel flow in light of solving scheme of bvp4c. Chemical reaction engulfs both solute and particle concentration. Growing viscosity hinders the fluid velocity and heats up the flow encouraging interlayer friction.