Flow injection amperometric determination of procaine in pharmaceutical formulation using a screen-printed carbon electrode

Bergamini, Márcio F.; Santos, André Luíz dos; Stradiotto, Nelson Ramos; Zanoni, María Valnice Boldrin

doi:10.1016/j.jpba.2006.06.001

Cited by 34 publications

(12 citation statements)

References 16 publications

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“…The procaine content was determined by the standard addition method, and the results were compared with the official method proposed in the United States Pharmacopoeia: extraction-spectrophotometric method based on its maximum absorbance signal at 280 nm. The results were in agreement with the results obtained by the extraction-spectrophotometric method, as well as the label values described by the industrial laboratory [43].…”

Section: Unmodified Spesupporting

confidence: 91%

Screen-Printed Electrodes (SPE) for Drug Compounds Determination

Özkan

Kauffmann

Zuman

2015

Monographs in Electrochemistry

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Section: Unmodified Spesupporting

confidence: 91%

Screen-Printed Electrodes (SPE) for Drug Compounds Determination

Özkan

Kauffmann

Zuman

2015

Monographs in Electrochemistry

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“…Reported amperometric methods for determining anestethics include screen-printed carbon electrodes ( Bergamini et al 2007), carbon paste (Dejmkova et al 2011) and multi-walled carbon nanotubes on glassy carbon (Guo et al 2013). In the case of anxiolytics, determination of buspyrone hydrochloride at multi-walled carbon nanotubes-modified electrode was reported (Cheemalapati et al 2013).…”

Section: Amperometric Methodsmentioning

confidence: 99%

Voltammetric/amperometric screening of compounds of pharmacological interest

Doménech‐Carbó

Carvalho

Martini

et al. 2014

Reviews in Analytical Chemistry

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Voltammetric and amperometric methods for screening compounds of pharmacological interest are reviewed on the basis of the types of electrodes and analytical strategies. The scope of conventional voltammetric and amperometric methods has been considerably expanded in the last years due to the development of a plethora of modified electrodes, in particular, those involving nanocomposites. The application of solid state voltammetric techniques for pharmacological screening has been also reviewed.

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“…Hydrodynamic conditions strongly improve the mass transport due to the forced convection and as a consequence, higher current values are obtained allowing the development of more sensible electroanalytical methods which have been successfully used for determination of drugs in pharmaceutical formulations. 16,18,44,45 Another advantage presented by amperometric detection is the shorter time of analysis because is not necessary to register a complete voltammogram. This advantage becomes more evident when amperometric detection is compared with differential pulse voltammetry which requires relatively low scan rates.…”

Section: Analytical Applicationsmentioning

confidence: 99%

Study of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations

Santos¹,

Takeuchi²,

Stradiotto³

et al. 2008

J. Braz. Chem. Soc.

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Neste trabalho, a redução eletroquímica do amebicida Teclozan (TEC) foi estudada sobre um eletrodo de carbono vítreo em meio de acetonitrila. Eletrólises com potencial controlado foram realizadas visando, tanto a determinação do número de elétrons envolvidos na redução do fármaco, quanto a identificação dos produtos eletrogerados, os quais foram isolados por extração líquido-líquido e caracterizados por 1 H RMN. Foi verificado que o TEC apresenta dois picos voltamétricos, cada um associado à quebra redutiva de duas ligações C-Cl. Em presença de um doador de prótons, foi observado que o primeiro pico voltamétrico em −1,8 V corresponde principalmente à redução dos grupamentos -CHCl 2 a -CH 2 Cl; enquanto o segundo pico em −2,2 V é responsável pela redução dos grupos -CH 2 Cl a CH 3 , fornecendo como único produto o derivado totalmente desalogenado do TEC, com rendimentos entre 82 e 97%. Este trabalho descreve também o desenvolvimento de um método eletroanalítico baseado na detecção amperométrica do TEC em condições hidrodinâmicas, o qual forneceu um limite de detecção de 8,9 × 10 -6 mol L -1 .The electrochemical reduction of amoebicide Teclozan (TEC) was studied on a glassy carbon electrode in acetonitrile. Controlled-potential electrolyses were performed for coulometric and preparative purposes. The electrogenerated products were isolated by liquid-liquid extraction and characterized by 1 H NMR. It was observed that TEC presents two voltammetric peaks, each one associated with the cleavage of two C-Cl bonds. In presence of a proton donor it was observed that the first peak at −1.8 V promotes mainly the reduction of the groups CHCl 2 to CH 2 Cl and the second one at −2.2 V promotes the reduction of the groups CH 2 Cl to CH 3 giving as the sole product the completely dechlorinated TEC derivative with yields between 82 and 97%. In addition, a comparative study between the analytical performance of voltammetric techniques and amperometric detection of TEC in hydrodynamic conditions was performed. The amperometric detection was more sensitive than all evaluated voltammetric techniques, providing a detection limit of 8.9 × 10 -6 mol L -1 .

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Flow injection amperometric determination of procaine in pharmaceutical formulation using a screen-printed carbon electrode

Cited by 34 publications

References 16 publications

Screen-Printed Electrodes (SPE) for Drug Compounds Determination

Screen-Printed Electrodes (SPE) for Drug Compounds Determination

Voltammetric/amperometric screening of compounds of pharmacological interest

Study of the electrochemical reduction of amoebicide teclozan and its amperometric determination in pharmaceutical formulations

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