Flow Injection Analysis of Polymeric Excipients Used in Pharmaceutical Formulations

Abstract

Both hydrophobic and hydrophilic polymer matrices are used in pharmaceutical controlled-release formulations. In order to fully understand the functionality of the polymer in the drug delivery device, it is useful to study both the properties of the material before formulation and the behavior of the polymer in situ. A flow injection size exclusion chromatography approach is described that permits the rapid determination of polymer properties. Examples are given for the application of this method to real-time monitoring of the polymerization of poly(lactide-co-glycolide) and to the study of polymer release from swellable matrix tablets.

The Effect of Fluid Shear Stress on the In Vitro Release Kinetics of Sirolimus from PLGA Films

“…A viscosity test was administered on the filtered solution by using an Ubbelohde viscometer at 25.0 ± 0.1 °C. The viscosity-average molecular weight of PLGA was obtained with the Mark–Houwink equation [ 49 ].…”

Preparation and Characterization of Poly (D,L-Lactide-co-Glycolide) (PLGA) Nanoparticles Loaded with Linamarin for Controlled Drug Release

“…[1][2][3] Among the different polymers, biodegradable polymers are the most widely used in medical applications. [4,5] Delivery systems based on biodegradable polymers are capable of improving drug stability, bioavailability, transport, release, and targeting properties, thus enhancing drug efficacy [6,7] Polyesters, poly lactic acid (PLA), poly (glycolic acid) (PGA), and poly (lactic-co-glycolic acid) (PLGA), are the most investigated biodegradable polymers [1,[8][9][10] for delivery of proteins and antigens, [2,11] peptides, [12,13] and plasmid DNA. [4,14] Polyesters are biocompatible [15][16][17] and biodegradable [18,19] due to hydrolytic cleavage of their ester bonds, [20][21][22] although some have considered the possibility of enzyme catalytic degradation.…”