Flow injection calibration techniques

Tyson, Julian F.

doi:10.1007/bf00624771

Cited by 44 publications

(15 citation statements)

References 26 publications

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“…Since it is difficult to directly obtain the more biologically active enantiomers of gossypol, methods to separate the racemic mixture have been developed. They involve transformation of gossypol into diastereoisomeric Schiff bases and subsequent separation by preparative HPLC and TLC resolutions [23][24][25][26]. In a next step hydrolysis of the diastereoisomeric Schiff bases yields optical pure enantiomers of gossypol.…”

Section: Methodsmentioning

confidence: 99%

Biological Properties of Schiff Bases and Azo Derivatives of Phenols

Przybylski¹,

Huczyński²,

Pyta³

et al. 2009

COC

392

206

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Aza-derivatives of phenols such as Schiff bases and hydrazones are an important and interesting group of chemical compounds. They exhibit a number of biological activities and play an important role in the regulation of many biochemical processes. Due to these properties, these compounds are potentialy useful for the design and production of novel anticancer, antimalaria, antivirus and antimicrobial drugs.The primary aim of the present review is to compare selected groups of phenol-derivatives containing azo-, heterocyclic, aromatic, alkyl and sugar moieties in view of their potential use and undesired effects, since some of them are widely used as dyes in the industry.Despite the vast number of azo derivatives of phenols which were synthesized and tested with respect to their biological activities, there is a continuous search for compounds of this group which might exhibit interesting, new biological effects.The main contribution to the development of Schiff base chemistry undoubtedly came from pharmaceutical research that began with the early studies of Hugo Schiff in the 19th century. Indeed, a vast number of publications on this matter underline the relevance of Schiff bases and related compounds in chemistry, pharmacy, biochemistry and industry. GOSSYPOLGossypol (Scheme 1) is a bisesquiterpene with interesting physico-chemical properties and pronounced biological activities. Despite many useful biological and physiological characteristics the main obstacle in using this compound as a drug is its relatively high toxicity and some other side effects [1][2][3][4][5]. The toxicity of gossypol is directed mainly towards the reproductive system, liver, heart and lipid membranes [6,7]. In the last thirty years biological and medical applications of gossypol and its derivatives mainly of its Schiff bases were on the focus of research. More than two thousand publications about gossypol and its derivates in medical therapy show the importance of this compound today. Scheme 1.

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Section: Methodsmentioning

confidence: 99%

Biological Properties of Schiff Bases and Azo Derivatives of Phenols

Przybylski¹,

Huczyński²,

Pyta³

et al. 2009

COC

392

206

View full text Add to dashboard Cite

show abstract

“…Considerable efforts have been devoted to the development of flow-injection based calibration techniques [39], particularly the standard ad ditions method, which has been implemented in a number of different ways. One of the most recent contributions in this area described a combined merging-zone zone-sampling manifold for the simultaneous determination of 19 elements in rock samples by ICP-OES by the generalized standard additions method [106].…”

Section: Precipitationmentioning

confidence: 99%

Atomic spectrometric detectors for flow-injection analysis

Tyson

1990

Analytica Chimica Acta

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“…Flow-injection techniques for calibration purposes, the majority of which concern applications to atomic spectrometry have recently been reviewed [ 32] and it is apparent that, since the last review of f.i. / a.s. [ 5], there have been several developments in the use of manifolds for on-line dilution and calibra tion.…”

Section: On-line Dilution and Calibrationmentioning

confidence: 99%

Atomic spectrometry and flow injection analysis: a synergic combination

Tyson

1988

Analytica Chimica Acta

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Flow injection calibration techniques

Cited by 44 publications

References 26 publications

Biological Properties of Schiff Bases and Azo Derivatives of Phenols

Biological Properties of Schiff Bases and Azo Derivatives of Phenols

Atomic spectrometric detectors for flow-injection analysis

Atomic spectrometry and flow injection analysis: a synergic combination

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