Flow-injection chemiluminometric determination of steroids

Deftereos, Nikolaos T.; Calokerinos, Antony C.

doi:10.1016/0003-2670(94)80056-1

Cited by 25 publications

(10 citation statements)

References 19 publications

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“…CHL has been determined by derivative spectrophotometry [16]. DEX and NAP have been simultaneously determined by using capillary electrophoresis in nose drops [17], while DEX has been quantified by flowinjection with chemiluminometric detection [18] and by derivative spectrophotometric determination in single formulations and also in combination with other drugs [19]. Our results are indicative that the combination of UV-visible spectroscopy with suitable chemometric techniques also constitutes a valid analytical strategy.…”

Section: Introductionmentioning

confidence: 88%

Complementary use of partial least-squares and artificial neural networks for the non-linear spectrophotometric analysis of pharmaceutical samples

Goicoechea

Collado

Satuf

et al. 2002

Analytical and Bioanalytical Chemistry

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The complementary use of partial least-squares (PLS) multivariate calibration and artificial neural networks (ANNs) for the simultaneous spectrophotometric determination of three active components in a pharmaceutical formulation has been explored. The presence of non-linearities caused by chemical interactions was confirmed by a recently discussed methodology based on Mallows augmented partial residual plots. Ternary mixtures of chlorpheniramine, naphazoline and dexamethasone in a matrix of excipients have been resolved by using PLS for the two major analytes (chlorpheniramine and naphazoline) and ANNs for the minor one (dexamethasone). Notwithstanding the large number of constituents, their high degree of spectral overlap and the occurrence of non-linearities, rapid and simultaneous analysis has been achieved, with reasonably good accuracy and precision. No extraction procedures using non-aqueous solvents are required.

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Section: Introductionmentioning

confidence: 88%

Complementary use of partial least-squares and artificial neural networks for the non-linear spectrophotometric analysis of pharmaceutical samples

Goicoechea

Collado

Satuf

et al. 2002

Analytical and Bioanalytical Chemistry

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“…The sensitising effect of corticosteroids on the chemoluminogenic reaction between sulfite and cerium(IV) was exploited for their flow-injection (FIA) determination in pharmaceutical formulations. 52,53 A luminol chemiluminescence determination for the same purpose is also described. 54…”

Section: ·6 Chemiluminometrymentioning

confidence: 99%

Recent Advances in the Analysis of Steroid Hormones and Related Drugs

Gǒrög¹

2004

ANAL. SCI.

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“…A variety of techniques is reported for the determination of progesterone in raw medicines, such as fluorescence, [2] high performance liquid chromatography (HPLC), [3] polarography, [4] chemiluminescence (CL) methods, [5,6] and immunoassay [7,8] . Ren et al [5] have developed chemiluminescence enzyme immunoassay for the determination of progesterone using luminal-hydrogen as chemiluminescence system catalyzed by horseradish peroxidase.…”

Section: Introductionmentioning

confidence: 99%

“…The linear range for the determination of progesterone is from 0.5 ∼ 60 µg·l −1 with a detection limit of 0.08 µg·l −1 . Deftereos and Calokerinos [6] have developed cerium (IV)-sulfite chemiluminescence system for the determination of steroids. The linear range for the determination of progesterone is from 1.0 ∼ 20 µg·ml −1 with a detection limit of 0.05 µg·ml −1 .…”

Section: Introductionmentioning

confidence: 99%

A sensitive flow injection chemiluminescence method for the determination of progesterone

Cao

Gong

Liu

et al. 2011

Drug Testing and Analysis

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A sensitive flow injection (FI) chemiluminescence (CL) method was developed for the determination of trace amounts of progesterone. This method was based on the luminescent properties of the tris(1,10-phenanthroline) ruthenium(II) - potassium permanganate (KMnO4 ) - progesterone in acidic medium sensitized by Na2 SO3 . With the peak height as a quantitative parameter applying optimum conditions, the relative CL intensity was linear with progesterone concentration in the range of 1.0 × 10(-10) ∼ 6.0 × 10(-9) g·ml(-1) and 6.0 × 10(-9) ∼ 4.0 × 10(-8) g·ml(-1) with a detection limit of 7.1 × 10(-11) g·ml(-1) . The relative standard deviation (RSD) was 2.79% for 1.0 × 10(-8) g·ml(-1) progesterone (n = 11). The proposed method held low detection limit and was successfully applied to determination of progesterone in pharmaceutical preparations. The possible CL reaction mechanism was also discussed.

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Flow-injection chemiluminometric determination of steroids

Cited by 25 publications

References 19 publications

Complementary use of partial least-squares and artificial neural networks for the non-linear spectrophotometric analysis of pharmaceutical samples

Complementary use of partial least-squares and artificial neural networks for the non-linear spectrophotometric analysis of pharmaceutical samples

Recent Advances in the Analysis of Steroid Hormones and Related Drugs

A sensitive flow injection chemiluminescence method for the determination of progesterone

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