Flow-mediated vasoactivity and circulating adhesion molecules in hypertriglyceridemia: Association with small, dense LDL cholesterol particles

Lupattelli, Graziana; Lombardini, Rita; Schillaci, Giuseppe; Ciuffetti, Giovańni; Marchesi, Simona; Siepi, Donatella; Mannarino, Elmo

doi:10.1067/mhj.2000.108508

Cited by 105 publications

(71 citation statements)

References 33 publications

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“…To the best of our knowledge there are no relevant studies in children, exploring this association. The findings of recent studies in adults (24,25) are in support of our suggestion as they provided evidence of a significant concordance between the two measures of endothelial dysfunction (ultrasonographic and biochemical, respectively).…”

Section: Discussionsupporting

confidence: 79%

The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood

Kavazarakis

2002

Pediatric Research

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Section: Discussionsupporting

confidence: 79%

The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood

Kavazarakis

2002

Pediatric Research

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“…12 An alternative to functional tests in the assessment of vascular function is the measurement of circulating factors released by damaged and dysfunctional endothelium. 28 Elevated plasma levels of such biomarkers, such as soluble ICAM-1 and soluble VCAM-1, correlate with impaired NO-dependent vasodilation, 29,30 which substantiates their use as a clinical tool for the assessment of endothelial dysfunction. 23 A low plasma HDL-C concentration is an independent predictor of impaired peripheral vasodilation in healthy individuals and in hyperlipidemic, diabetic, and coronary patients.…”

Section: Gomaraschi Et Al Vascular Function In Apoa-i M Carriersmentioning

confidence: 99%

Normal Vascular Function Despite Low Levels of High-Density Lipoprotein Cholesterol in Carriers of the Apolipoprotein A-I _Milano Mutant

et al. 2007

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Background-Carriers of the apolipoprotein A-I Milano (apoA-I M ) mutant have very low plasma high-density lipoprotein cholesterol (HDL-C) levels but do not show any history of premature cardiovascular disease or any evidence of preclinical vascular disease. HDL is believed to prevent the development of vascular dysfunction, which may well contribute to HDL-mediated atheroprotection. Whether the low HDL level of apoA-I M carriers is associated with impaired vascular function is presently unknown. Methods and Results-The vascular response to reactive hyperemia, assessed by measuring postischemic increase in forearm arterial compliance, and the plasma concentration of soluble cell adhesion molecules were evaluated in 21 adult apoA-I M carriers, 21 age-and gender-matched nonaffected relatives (control subjects), and 21 healthy subjects with low HDL-C (low-HDL subjects). The average plasma HDL-C and apoA-I levels of apoA-I M carriers were remarkably lower than those of control subjects and significantly lower than those of low-HDL subjects. The postischemic increase in forearm arterial compliance in the apoA-I M carriers was 2-fold greater than in low-HDL subjects and remarkably similar to that of control subjects. Plasma soluble cell adhesion molecule levels were similar in apoA-I M carriers and control subjects but were greater in low-HDL subjects. When incubated with endothelial cells, HDL isolated from apoA-I M carriers was more effective than HDL from control and low-HDL subjects in stimulating endothelial nitric oxide synthase expression and activation and in downregulating tumor necrosis factor-␣-induced expression of vascular cell adhesion molecule-1. Conclusions-Despite their very low HDL levels, apoA-I M carriers do not display typical features of impaired vascular function because of an improved activity of apoA-I M HDL in maintaining endothelial cell homeostasis. (Circulation.

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“…Metabolic abnormalities found in diabetes such as hyperinsulinaemia, hyperglycaemia, and dyslipidaemia along with oxidative stress were all shown to contribute to endothelial dysfunction. [35][36][37][38][39] In turn, endothelial dysfunction was also shown to be present in very early stages of atherosclerosis, 40 suggesting, but not proving, that endothelial dysfunction may be a pathophysiological link explaining the high rate of vascular complications in diabetes.…”

Section: Endothelialmentioning

confidence: 99%

Review article: Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus

Anderssohn

Schwedhelm

Lüneburg

et al. 2010

Diabetes and Vascular Disease Research

114

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Asymmetric dimethylarginine (ADMA) has evolved as an important regulator of nitric oxide (NO) synthesis in recent years. Elevated levels of ADMA have been reported in many conditions associated with a high cardiovascular risk. Moreover, ADMA is a biomarker for major cardiovascular events and mortality in cohorts with high, intermediate and low overall cardiovascular risk. Discrepant data have been reported on cardiovascular risk in people with and without diabetes mellitus, and the association of ADMA with diabetes mellitus per se has also remained controversial, possibly relating to type and stage of diabetes. Clinical and experimental data suggest that there is a multifaceted link between ADMA and insulin metabolism and action on one hand, and ADMA and glucose utilisation on the other. This interplay may be regulated by the enzyme involved in the metabolic degradation of ADMA, dimethylarginine dimethylaminohydrolase (DDAH). Recent data from prospective clinical studies suggest that whilst ADMA may be a marker for total mortality in patients without diabetes, elevated ADMA may exert beneficial effects in patients with diabetes. In this respect, ADMA could serve as a re-coupling agent overcoming endothelial nitric oxide synthase (eNOS) uncoupling in patients with diabetes. Anticipated advances in clinical and experimental investigation will help us to better understand this complex interrelationship between diabetes, eNOS, DDAH and ADMA.

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Flow-mediated vasoactivity and circulating adhesion molecules in hypertriglyceridemia: Association with small, dense LDL cholesterol particles

Cited by 105 publications

References 33 publications

The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood

The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood

Normal Vascular Function Despite Low Levels of High-Density Lipoprotein Cholesterol in Carriers of the Apolipoprotein A-I _Milano Mutant

Review article: Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus

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Flow-mediated vasoactivity and circulating adhesion molecules in hypertriglyceridemia: Association with small, dense LDL cholesterol particles

Cited by 105 publications

References 33 publications

The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood

The Impact of Serum Lipid Levels on Circulating Soluble Adhesion Molecules in Childhood

Normal Vascular Function Despite Low Levels of High-Density Lipoprotein Cholesterol in Carriers of the Apolipoprotein A-I Milano Mutant

Review article: Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus

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Normal Vascular Function Despite Low Levels of High-Density Lipoprotein Cholesterol in Carriers of the Apolipoprotein A-I _Milano Mutant