Flow Rate and Raspberry Pi-Based Paper Microfluidic Blood Coagulation Assay Device

Sweeney, Robin E.; Nguyen, Vina; Alouidor, Benjamin; Budiman, Edy; Wong, Raymond Chi-Wing; Yoon, Jeong‐Yeol

doi:10.1109/jsen.2019.2902065

Cited by 17 publications

(7 citation statements)

References 19 publications

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“…For instance, reductive work up of 1,2-dialkyl-substituted olefins results in alcohols or aldehydes, while oxidative work up leads to carboxylic acids. 39,40 The mechanism of ozonolysis was first proposed by Criegee 40 and more recently confirmed by Berger using 17 O NMR spectroscopy. 41 In the ozonolysis mechanism, the electrophilic addition of ozone to the π-bond first forms a 5-membered molozonide intermediate (prime ozonide), which rapidly rearranges to create the secondary ozonide in organic solvents.…”

Section: Discussionmentioning

confidence: 93%

“… 16 In chemistry, microcontroller microcomputer boards combined with cost-effective sensors were applied to monitor and optimize chemical reactions for both batch and flow processes, reducing operator intervention for product purification and supervision. 17 Open-source hardware can also be applied to flow chemistry systems, lowering the barrier to entry for conducting these experiments. Syringe pumps assembled using open-source 3D models and off-the-shelf parts can provide DIY solutions to challenging applications such as multistep chemical syntheses when combined with open-source code.…”

Section: Introductionmentioning

confidence: 99%

“…Science and medicine have offered creative applications, where Arduino controller setups provide basic sensors to perform diverse experiments. − Freely available plans, open-source code, and programming flexibility also enabled healthcare applications such as acoustofluidics to lower point-of-care medical costs . In chemistry, microcontroller microcomputer boards combined with cost-effective sensors were applied to monitor and optimize chemical reactions for both batch and flow processes, reducing operator intervention for product purification and supervision . Open-source hardware can also be applied to flow chemistry systems, lowering the barrier to entry for conducting these experiments.…”

Section: Introductionmentioning

confidence: 99%

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Laboratory Ozonolysis Using an Integrated Batch–DIY Flow System for Renewable Material Production

et al. 2022

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Flow chemistry offers a solution for replacing batch methods in chemical preparation where intermediates or products may pose toxicity or instability hazards. Ozonolysis offers an ideal opportunity for flow chemistry solutions, but multiple barriers to entry exist for use of these methods, including equipment cost and performance optimization. To address these challenges, we developed a programmable DIY syringe pump system to use for a continuous flow multireactor process using 3D-printed parts, off-the-shelf stepper motors, and an Arduino microcontroller. Reaction kinetics of ozonide formation informed the use of an integrated batch–flow approach, where ozone addition to an olefin was timed to coincide with fluid movement of a single-syringe pump, followed by downstream Pinnick oxidation and reductive quench in flow. The system was demonstrated by continuous preparation of azelaic acid from ozonolysis of palmitoleic acid, a process limited to low production volumes via batch chemistry. High total production of azelaic acid with 80% yield was obtained from an algae oil sourced unsaturated fatty acid: a product with important applications in medicine, cosmetics, and polymers. This low-cost, scalable approach offers the potential for rapid prototyping and distributed chemical production.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laboratory Ozonolysis Using an Integrated Batch–DIY Flow System for Renewable Material Production

et al. 2022

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“…Importantly, the DIY approach is potentially applicable in many fields. For instance, with respect to medical applications, Sweeney et al [17] describe the development of a cost-effective alternative for measuring blood clotting time in patients. For museums, a low-cost surveillance and information system is presented in [18] which protects paintings from camera flashlights and visitors who get too close to the paintings.…”

Section: Related Workmentioning

confidence: 99%

A DIY Low-Cost Wireless Wind Data Acquisition System Used to Study an Arid Coastal Foredune

Domínguez‐Brito

Cabrera‐Gámez

Viera-Pérez

et al. 2020

Sensors

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Environmental studies on coastal dune systems are faced with a considerable cost barrier due to the cost of the instrumentation and sensory equipment required for data collection. These systems play an important role in coastal areas as a protection against erosion and as providers of stability to coastal sedimentary deposits. The DIY (Do-It-Yourself) approach to data acquisition can reduce the cost of these environmental studies. In this paper, a low-cost DIY wireless wind data acquisition system is presented which reduces the cost barrier inherent to these types of studies. The system is deployed for the analysis of the foredune of Maspalomas, an arid dune field situated on the south coast of Gran Canaria (Canary Islands, Spain), for the specific purpose of studying the dynamics of a dune type (tongue dunes), which is typical of this environment. The results obtained can be of interest for the study of these coastal environments at both the local level, for the management of this particular dune field, and at the general level for other similar dune fields around the world.

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“…Single-board computers, such as the Raspberry Pi , have recently proven to be an effective way to reduce the cost and size of medical and scientific instruments, without sacrificing performance [25]- [29]. The low-cost and availability of open-source software frameworks make these computers a versatile tool in the development of point-of-care devices for use in low-resource settings.…”

Section: Introductionmentioning

confidence: 99%

Development of Low-Cost Point-of-Care Technologies for Cervical Cancer Prevention Based on a Single-Board Computer

Parra

Carranza

Coole

et al. 2020

IEEE J. Transl. Eng. Health Med.

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Cervical cancer disproportionally affects women in low-and middle-income countries, in part due to the difficulty of implementing existing cervical cancer screening and diagnostic technologies in lowresource settings. Single-board computers offer a low-cost alternative to provide computational support for automated point-of-care technologies. Here we demonstrate two new devices for cervical cancer prevention that use a single-board computer: 1) a low-cost imaging system for real-time detection of cervical precancer and 2) a low-cost reader for real-time interpretation of lateral flow-based molecular tests to detect cervical cancer biomarkers. Using a Raspberry Pi computer to provide real-time image collection and processing, we developed: 1) a low-cost, portable high-resolution microendoscope system (PiHRME); and 2) a low-cost automatic lateral flow test reader (PiReader). The PiHRME acquired high-resolution (4.4 µm) images of the cervix at half the cost of existing high-resolution microendoscope systems; image analysis algorithms based on convolutional neural networks were implemented to provide real-time image interpretation. The PiReader acquired and analyzed images of a point-of-care human papillomavirus (HPV) serology test with the same contrast and accuracy as a standard flatbed high-resolution scanner coupled to a laptop computer, for less than one-fifth of the cost. Raspberry Pi single-board computers provide a low-cost means to implement point-ofcare tools with automatic image analysis. This work demonstrates the promise of single-board computers to develop and translate low-cost, point-of-care technologies for use in low-resource settings. INDEX TERMS Cervical cancer prevention, low-cost medical technology, point-of-care, Raspberry Pi.

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Flow Rate and Raspberry Pi-Based Paper Microfluidic Blood Coagulation Assay Device

Cited by 17 publications

References 19 publications

Laboratory Ozonolysis Using an Integrated Batch–DIY Flow System for Renewable Material Production

Laboratory Ozonolysis Using an Integrated Batch–DIY Flow System for Renewable Material Production

A DIY Low-Cost Wireless Wind Data Acquisition System Used to Study an Arid Coastal Foredune

Development of Low-Cost Point-of-Care Technologies for Cervical Cancer Prevention Based on a Single-Board Computer

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