Flow Through Interstitium and Other Fibrous Matrices

Levick, J. R.

doi:10.1113/expphysiol.1987.sp003085

Cited by 441 publications

(424 citation statements)

References 54 publications

(112 reference statements)

Supporting

Mentioning

412

Contrasting

Unclassified

Order By: Relevance

“…The sparser collagen scaffold and reduced fibril diameters in fibromodulin-deficient carcinoma would by itself raise the hydraulic conductivity. The increased ECV will also contribute to increased conductivity in the stroma by effectively diluting matrix components (37). The increased hydraulic conductivity will favor a flow of fluid from parts of the tumor with a high IFP to the periphery where IFP is lower.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma

Oldberg¹,

Kalamajski²,

Salnikov

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Research on the biology of the tumor stroma has the potential to lead to development of more effective treatment regimes enhancing the efficacy of drug-based treatment of solid malignancies. Tumor stroma is characterized by distorted blood vessels and activated connective tissue cells producing a collagen-rich matrix, which is accompanied by elevated interstitial fluid pressure (IFP), indicating a transport barrier between tumor tissue and blood. Here, we show that the collagen-binding proteoglycan fibromodulin controls stroma structure and fluid balance in experimental carcinoma. Gene ablation or inhibition of expression by antiinflammatory agents showed that fibromodulin promoted the formation of a dense stroma and an elevated IFP. Fibromodulindeficiency did not affect vasculature but increased the extracellular fluid volume and lowered IFP. Our data suggest that fibromodulin controls stroma matrix structure that in turn modulates fluid convection inside and out of the stroma. This finding is particularly important in relation to the demonstration that targeted modulations of the fluid balance in carcinoma can increase the response to cancer therapeutic agents.physiology ͉ TGF-␤ ͉ tumor physiology ͉ inflammation ͉ interstitial fluid pressure

show abstract

Section: Discussionmentioning

confidence: 99%

“…The composition of the ECM determines hydraulic conductivity in tissues (37), and irradiation of experimental tumor increases collagen content and reduces hydraulic conductivity (38). The sparser collagen scaffold and reduced fibril diameters in fibromodulin-deficient carcinoma would by itself raise the hydraulic conductivity.…”

Section: Discussionmentioning

confidence: 99%

Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma

Oldberg¹,

Kalamajski²,

Salnikov

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…Clearly, some compartments of this space will be too small for albumin to penetrate, but their small size also means they will have a high resistance to flow, and therefore disproportionately little involvement in transmural water flux. For example, the water inside collagen fibrils is not significantly involved in water transport through interstitium and albumin will also be excluded from this space, which has a hydrodynamic radius of only 0.6 nm (ref to : Levick (1987)). Even if a fixable fluorescent tracer with the same size as water existed, its distribution would not be a useful indicator of the spaces involved in water transport…”

Section: Permeability Of Rat Arterial Mediamentioning

confidence: 99%

A combined numerical and experimental framework for determining permeability properties of the arterial media

Comerford

Chooi

Nowak

et al. 2014

Biomech Model Mechanobiol

View full text Add to dashboard Cite

The medial layer of the arterial wall may play an important role in the regulation of water and solute transport across the wall. In particular, a high medial resistance to transport could cause accumulation of lipid carrying molecules in the inner wall. In this study, the water transport properties of medial tissue were characterised in a numerical model utilising experimentally obtained data for the medial microstructure and the relative permeability of di↵erent constituents. For the model, a new solver for flow in porous materials, based on a high-order splitting scheme, was implemented in the spectral/hp element library nektar++ and validated. The data were obtained by immersing excised aortic bifurcations in a solution of fluorescent protein tracer and subsequently imaging them with a confocal microscope. Cuboidal regions of interest were selected in which the microstructure and relative permeability of di↵erent structures were transformed to a computational mesh. Impermeable objects were treated fictitiously in the numerical scheme. On this cube, a pressure drop was applied in the three coordinate directions and the principal components of the permeability tensor were determined. The reconstructed images demonstrated the arrangement of elastic lamellae and interspersed smooth muscle cells in rat aortic media; the distribution and alignment of the smooth muscle cells varied spatially within the extracellular matrix. The numerical simulations high-

show abstract

“…Considering the microstructure of the gel is beyond the scope of this work, and so we begin with ℓ o = 2 µm as a starting value. We note that the hydraulic resistivity of fibrin is much lower (and ℓ o much larger) than other physiological fibrous materials (Levick 1987).…”

Section: Parameters and Scalingsmentioning

confidence: 99%

Fibrin gel formation in a shear flow

Guy

Fogelson²,

Keener³

2007

Mathematical Medicine and Biology: A Journal of the IMA

View full text Add to dashboard Cite

Blood clots are made up of platelets and fibrin gel, and the relative amount of fibrin is strongly influenced by the shear rate. In order to explore this phenomenon, this paper presents a model of fibrin gel formation over the surface of an injured blood vessel in a shear flow. A condition for gelation including source and sink terms of polymer is derived. A simplified model of coagulation, involving activation and inhibition of the enzyme thrombin and thrombinmediated production of fibrin monomer, is combined with the model of gelation to explore how the shear rate and other parameters control the formation of fibrin gel. The results show that the thrombin inhibition rate, the gel permeability, and the shear rate are key parameters in regulating the height of the fibrin gel.

show abstract

Flow Through Interstitium and Other Fibrous Matrices

Cited by 441 publications

References 54 publications

Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma

Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma

A combined numerical and experimental framework for determining permeability properties of the arterial media

Fibrin gel formation in a shear flow

Contact Info

Product

Resources

About