Flower Bracts of Temulawak (Curcuma Xanthorrhiza) for Skin Care: Anti-acne and Whitening Agents

Batubara, Irmanida; Julita, Iren; Darusman, Latifah Kosim; Muddathir, Ali Mahmoud; Mitsunaga, Tohru

doi:10.1016/j.proche.2015.03.031

Cited by 34 publications

(23 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the case of Curcuma xanthorrhiza, a plant widely used in traditional medicine, considerable differences will be observed depending on the part chosen. The rhizome extract in ethyl acetate is ten times less effective than the kojic acid standard, whereas the bract extract in the same solvent is 100 times less so, which clearly eliminates any possibility of skin lightening applications [90].…”

Section: Tyrosinase Inhibitors Offering New Avenues In the Field Of Smentioning

confidence: 99%

Overview of Skin Whitening Agents: Drugs and Cosmetic Products

2016

View full text Add to dashboard Cite

Depigmentation and skin lightening products, which have been in use for ages in Asian countries where skin whiteness is a major esthetic criterion, are now also highly valued by Western populations, who expose themselves excessively to the sun and develop skin spots as a consequence. After discussing the various possible mechanisms of depigmentation, the different molecules that can be used as well as the status of the products containing them will now be presented. Hydroquinone and derivatives thereof, retinoids, alpha-and beta-hydroxy acids, ascorbic acid, divalent ion chelators, kojic acid, azelaic acid, as well as diverse herbal extracts are described in terms of their efficacy and safety. Since a genuine effect (without toxic effects) is difficult to obtain, prevention by using sunscreen products is always preferable.

show abstract

Section: Tyrosinase Inhibitors Offering New Avenues In the Field Of Smentioning

confidence: 99%

Overview of Skin Whitening Agents: Drugs and Cosmetic Products

2016

View full text Add to dashboard Cite

show abstract

“…Antimicrobial effects of XNT included antibacterial [50][51][52]. XNT also strongly inhibited Gram-positive bacteria S. aureus, methicillin-resistant S. aureus, Gram-negative bacteria E. coli [53], and acne-causing bacteria Propionibacterium acnes [54].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…It was found that the extract targeted C. zedoaria Rosc. is a commonly available plant in the dava-bazaar as Kachore is a potential antimicrobial agent as it shows significant activity against common bacterial and fungal pathogen [55]. It also is very common ingredient of body deodorant (ubtans), hair oils, and face washes [56,57].…”

Section: Antivenom Activitymentioning

confidence: 99%

An Overview of Medicinal Value of Curcuma Species

Kanase¹,

Khan²

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Curcuma is a genus of about 100 accepted species in the family Zingiberaceae that contains such species as turmeric and Siam tulip. They are native to Southeast Asia, southern China, ISSN (Online): 2319-7064 ISSN (Online): 2319-7064 naturalized in other warm parts of the world such as Tropical Africa, Central America, Florida, and various islands of the Pacific, Indian, and Atlantic Oceans. Few known species of Curcuma with reported pharmacological activity are Curcuma longa, Curcuma aeruginosa, Curcuma pseudomontana, Curcuma aromatica, Curcuma xanthorrhiza, Curcuma zedoaria, Curcuma angustifolia. Among them, C. longa is the one species extensively studied and has ancient traditional medicinal uses. These Curcuma species have been used in traditional medicine as a household remedy for various diseases, including biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. For the past few decades, extensive work has been done to establish the biological activities and pharmacological actions of Curcuma species and its extracts. This review article is created with an intention to give an overview on the reported research carried out on the Curcuma species such as anticancer activity, antitumor, antitubercular, antibacterial, antimicrobial, toxicity activity, and wound healing. And also, these Curcuma species can be considered as herbal medicinal plant having a plethora of research opportunities based on its traditional use and biological activity.

show abstract

“…This may be due to the fact that CX contains an enormous amount of polyphenolic compounds [38], which are potent antioxidants as a result of their metal chelating properties [39]. Moreover, the high chelating effect may be due to the ability of xanthorrhizol, the major active compound in CX, to chelate Cu 2+ ions and inhibits the initiation of free radical formation [40], which could be attributed to tyrosinase inhibition activity [41]. Fig.…”

Section: Metal Chelating Activitymentioning

confidence: 99%

Selective Anticancer Activity of Curcuma Xanthorrhiza Fermented Juices

Ruksiriwanich¹,

Akazawa

Jantrawut³

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The objective of this study was to investigate the anticancer activity and toxicity of fermented juices from six Thai plants, Garcinia mangostana Linn., Tinospora crispa Linn., Litchi chinensis Sonn., Dimocarpus longan Lour., Curcuma xanthorrhiza (CX) Roxb., and Averrhoa bilimbi Linn., in cancer cell lines and normal cells as compared with common commercial fermented juices. Methods:The plants were fermented for 3 months, and their biological activities including 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) scavenging, metal chelating, lipid peroxidation inhibition, and tyrosinase inhibition activities were subsequently evaluated. Furthermore, their in vitro anticancer activities in human colon adenocarcinoma (HT-29), cervical cancer (HeLa), hepatocellular carcinoma (HepG2), and murine melanoma (B16F10) cell lines and their toxicities in normal human skin fibroblasts were assessed. Results:The fermented juice of CX showed a higher antioxidant activity than those of the other plants, with an SC 50 (DPPH scavenging) value of 0.011 mg/mL, an IPC 50 (lipid peroxidation inhibition) of 0.027 mg/mL, an MC 50 (metal chelating) value of 0.170 mg/mL, and an IC 50 (tyrosinase inhibition) of 0.027 mg/mL. Moreover, the fermented juice of CX displayed selective toxicity in cancer cell lines (HeLa, HepG2, and B16F10), with a significantly lower toxicity in normal human skin fibroblasts as compared with an expensive commercial fermented juice product. Conclusion:The present study suggests that the fermented juice of CX can be developed as a functional food supplement with antioxidant properties or as an anticancer product with low toxicity to normal human skin fibroblasts.

show abstract

Flower Bracts of Temulawak (Curcuma Xanthorrhiza) for Skin Care: Anti-acne and Whitening Agents

Cited by 34 publications

References 13 publications

Overview of Skin Whitening Agents: Drugs and Cosmetic Products

Overview of Skin Whitening Agents: Drugs and Cosmetic Products

An Overview of Medicinal Value of Curcuma Species

Selective Anticancer Activity of Curcuma Xanthorrhiza Fermented Juices

Contact Info

Product

Resources

About