Flower-like Plasma cell: a Comment

Primary plasma cell leukemia presented with atypical flower‐like morphology

“…3 Occasionally, its morphological appearance poses a diagnostic dilemma mimicking flower-cells. 1,2 Similarly to previous reports, our case had unusual flower-like morphology, plasma cell phenotpe, IGH gene rearrangement, unfavorable features including CD56+ and two adverse genetic leasions amplification 1q21, deletion 1p32. [1][2][3] Moreover as oligosecretory, it has rapid progression, secondary immunodeficiency and subsequent infection.…”

“…Typical morphology in primary plasma cell leukemia (pPCL) usually resembles small mature plasma cells. However, diagnosis is sometimes challenging, as most of neoplastic cells present irregular, multilobulated or petal‐shaped nuclei 1,2 . Clear identification of these unusual morphological variants is important to avoid misdiagnosis of adult T‐cell leukemia/lymphoma, reactive monocytes in viral infection, seldom B‐cell lymphoma 1 .…”

“…Usually it occurs in younger patients, has a more aggressive course and poor outcome 3 . Occasionally, its morphological appearance poses a diagnostic dilemma mimicking flower‐cells 1,2 …”

“…However, diagnosis is sometimes challenging, as most of neoplastic cells present irregular, multilobulated or petal-shaped nuclei. 1,2 Clear identification of these unusual morphological variants is important to avoid misdiagnosis of adult T-cell leukemia/lymphoma, reactive monocytes in viral infection, seldom B-cell lymphoma. 1 This paper presents a rare case of pPCL with atypical flower-like morphology.…”

Caution the Difference Between the Flower-like Lymphocyte with Flower-like Plasma Cell

“…These authors reported a case of multiple myeloma showing abnormal plasma cells with flower-shaped nuclear features. These cells with flower-shaped nuclei have also been reported in cases of plasma cell leukemia in previous studies [ 2 , 3 , 4 , 5 ]. The authors described the morphological features of flower-like cells in order to help pathologists identify them for diagnostic purposes.…”