Flowers of Hibiscus rosa-sinensis, a potential source of contragestative agent. III: Interceptive effect of benzene extract in mouse

Pakrashi, Anita; Bhattacharya, Sayantani Sarkar; Kabir, Syed N.; Pal, Alok K.

doi:10.1016/0010-7824(86)90061-2

Cited by 13 publications

(11 citation statements)

References 17 publications

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“…Literature survey of the cited plants confirmed that Abrus precatorius (Ross, 2005;Okoko et al, 2010), Acalypha indica (Hafez, 1970;Shivayogi et al, 1999), Ailanthus excelsa (Ravichandran et al, 2007), Ananas comosus (Bhaduri et al, 1968;Garó et al, 1970;Näf-Müller and Willhalm, 1971), Aristolochia bracteolata (Natraj et al, 2007), Azadirachta indica (Riar et al, 1991;Sinha et al, 1984a,b), Bambusa vulgaris (Yakubu and Bukoye, 2009), Embelia ribes (Radhakrishnan and Alam, 1975;Garg and Garg, 1978;Prakash, 1981), Hibiscus rosa-sinensis (Pakrashi et al, 1986;Vasudeva and Sharma, 2008), Plumbago zeylanica (Premakumari et al, 1977;Chowdhury et al, 1982;Edwin et al, 2009), Vicoa indica (Dhall and Dogra, 1988;Rao et al, 1996) potent antifertility effects.…”

Section: Discussionmentioning

confidence: 96%

“…HR ethanolic root extract, at dose of 400 mg/kg body weight orally from day 1 to 7 of gestation, prevented pregnancy in colony-bred female albino rats and showed strong anti-implantation (inhibition 100%) and uterotropic activities (Vasudeva and Sharma, 2008). In another study on mice, oral administration of the benzene extract of HR flowers, at a dose level of 1 g/kg body weight/day from days 5 to 8 of gestation, led to termination of pregnancy in about 92% of the animals where the effect was associated with a significant fall in peripheral level of progesterone and increase in uterine acid phosphatase activity, as measured on day 10 (Pakrashi et al, 1986). Olagbende-Dada et al (2007) reported the anabolic effect of leaf extract of this plant in immature albino male rats.…”

Section: Hibiscus Rosa-sinensis Linn (Malvaceae)mentioning

confidence: 96%

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Potential antifertility agents from plants: A comprehensive review

Kumar

Prakash

2012

Journal of Ethnopharmacology

123

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Section: Discussionmentioning

confidence: 96%

Section: Hibiscus Rosa-sinensis Linn (Malvaceae)mentioning

confidence: 96%

Potential antifertility agents from plants: A comprehensive review

Kumar

Prakash

2012

Journal of Ethnopharmacology

123

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“…The drug is having antifertility and antispermatogenic and antiestrogenic activities [63][64][65][66][67]80]. Benzene extract of flower in 250 mg/kg from day 1 to day 10 of pregnancy in rats was found most effective to prevent pregnancy.…”

Section: Japakusuma (H Rosa-sinensis)mentioning

confidence: 99%

Herbal Contraceptives: Evaluation of Antifertility Potential of Hibiscus Rosa‑sinensis (Linn.)

Chauhan

Naved

2018

Asian J Pharm Clin Res

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This review explores, evaluates, and analyzes the contraceptive potential of Hibiscus rosa-sinensis L. There are large numbers of synthetic contraceptives available in the market. These synthetic contraceptives are associated with many side effects ranging from user discomfort to toxicity. India is a land of traditional herbal medicines. People are finding and exploring the advantages associated with herbal contraceptives because of their lower side effects. Herbal contraceptives have lower cost of development as compared to modern medicine. This review explores the recent advances in development that offers many benefits for shifting the paradigm for herbal contraceptives. From times immemorial, references have been made for the plants that possess antifertility properties. This review explores the need for the development of herbal contraceptives from the plant H. rosa-sinensis L. H. rosa-sinensis L is reported to have antiovulatory activity. However, the need of the hour is to assess and carry out toxicological studies and initiate development activity for formulation development.

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“…12) The group assignment and experimental schedule were the same as described in the UVB radiation experiment above. Brie‰y, 24 mice were randomly divided into 4 groups (n＝6), and all groups were treated with a consecutive intraperitoneal administration of progesterone, with the exception of the normal mice that were treated with corn oil only (Fig.…”

Section: Chemicals and Uv Radiationmentioning

confidence: 99%

Effects of <i>keishibukuryoganryokayokuinin</i> (gui-zhi-fu-ling-wanliao-jia-yiyiren) on the Epidermal Pigment Cells from DBA/2 Mice Exposed to Ultraviolet B (UVB) and/or Progesterone

Norimoto¹,

Yomoda²,

Fujita³

et al. 2011

YAKUGAKU ZASSHI

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The production of melanin is not only activated by external factors such as sunlight or UV-exposure, but is also considered to be triggered by hormonal factors, particularly sex hormones such as ovarian hormones. Previously, keishibukuryoganryokayokuinin (KBY) was reported to increase the pigmentation and moisture content of dermis in women during the luteal phase of the menstrual cycle, thus suggesting that progesterone could play a critical role in the development of skin pigmentation. In the present study, female DBA/2 mice, a dilute brown strain, were used to examine the effects of KBY on the increase in epidermal pigment cells in mice exposed to ultraviolet B (UVB) radiation or progesterone in an attempt to elucidate its mechanism. An increase in epidermal pigment cells was observed in mice exposed to progesterone. To the best of our knowledge, this is the first study to demonstrate that progesterone causes pigmentation in vivo. Furthermore, administration of KBY to progesterone-exposed mice significantly reduced the number of epidermal pigment cells. However, KBY had no such effects on UVB-induced pigmentation. Another important finding was the gain in body weight in progesterone-exposed mice, while body weight gain was reduced by KBY. The body weight gain was believed to be due to sodium and fluid retention, a kind of adverse effect of progesterone, which may further affect the intracellular pH of melanosomes, which synthesize melanin, in turn, leading to melanin production because tyrosinase activity is linked to the intracellular pH environment. This may help explain the mechanism of the role of KBY in pigmentation.

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Flowers of Hibiscus rosa-sinensis, a potential source of contragestative agent. III: Interceptive effect of benzene extract in mouse

Cited by 13 publications

References 17 publications

Potential antifertility agents from plants: A comprehensive review

Potential antifertility agents from plants: A comprehensive review

Herbal Contraceptives: Evaluation of Antifertility Potential of Hibiscus Rosa‑sinensis (Linn.)

Effects of <i>keishibukuryoganryokayokuinin</i> (gui-zhi-fu-ling-wanliao-jia-yiyiren) on the Epidermal Pigment Cells from DBA/2 Mice Exposed to Ultraviolet B (UVB) and/or Progesterone

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