Floxuridine Homomeric Oligonucleotides “Hitchhike” with Albumin In Situ for Cancer Chemotherapy

Cheng, Jinghui; Zhang, Hui; Zou, Jianmei; Liu, Yan; Zhang, Lin; Li, Fengjie; Wang, Ruowen; Xuan, Wenjing; Ye, Mao; Tan, Weihong

doi:10.1002/anie.201804156

Cited by 71 publications

(62 citation statements)

References 33 publications

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“…Floxuridine-Embedded DNA Amphiphiles: Floxuridine is a nucleoside analog, which is used as an antitumor drug. [70,122] Due to its structural similarity to thymine (T) nucleoside, fluorouridine can replace T in the NA sequence without affecting the base-pairing capability. Therefore, floxuridine can be embedded in the NA sequence by replacing T during DNA solid-phase synthesis ( Figure 10C).…”

Section: Design Principle Of Delivery System Based On Dna Amphiphilesmentioning

confidence: 99%

“…Tan and co-workers developed a lipidconjugated floxuridine homomeric oligonucleotide (FU20), a widely used therapeutic nucleobase analogue, the systemic delivery of which could be enhanced by "hitchhike" with albumin ( Figure 13A). [122] Owing to the modification of diacyl lipid, the FU20-lipid amphiphile self-assembled into micelles and could noncovalently attach with albumin through the interaction of lipid and albumin hydrophobic core during blood circulation, which resulted in a sufficient tumor accumulation. After the endocytosis of cancer cells, FU20-lipid/albumin complexes would be hydrolyzed by lysosome to release FU20 and inhibited cancer cell proliferation.…”

Section: Instance Of Applicationsmentioning

confidence: 99%

Section: Instance Of Applicationsmentioning

confidence: 99%

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Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

et al. 2020

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The comprehensive understanding and proper use of supramolecular interactions have become critical for the development of functional materials, and so is the biomedical application of nucleic acids (NAs). Relatively rare attention has been paid to hydrophobic interaction compared with hydrogen bonding and electrostatic interaction of NAs. However, hydrophobic interaction shows some unique properties, such as high tunability for application interest, minimal effect on NA functionality, and sensitivity to external stimuli. Therefore, the widespread use of hydrophobic interaction has promoted the evolution of NA-based biomaterials in higher-order self-assembly, drug/gene-delivery systems, and stimuli-responsive systems. Herein, the recent progress of NA-based biomaterials whose fabrications or properties are highly determined by hydrophobic interactions is summarized. 1) The hydrophobic interaction of NA itself comes from the accumulation of base-stacking forces, by which the NAs with certain base compositions and chain lengths show properties similar to thermal-responsive polymers. 2) In conjugation with hydrophobic molecules, NA amphiphiles show interesting self-assembly structures with unique properties in many new biosensing and therapeutic strategies. 3) The working-mechanisms of some NA-based complex materials are also dependent on hydrophobic interactions. Moreover, in recent attempts, NA amphiphiles have been applied in organizing macroscopic self-assembly of DNA origami and controlling the cell-cell interactions.

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Section: Design Principle Of Delivery System Based On Dna Amphiphilesmentioning

confidence: 99%

Section: Instance Of Applicationsmentioning

confidence: 99%

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Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

et al. 2020

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“…As discussed before, HSA is the most abundant plasma protein found in human blood with a concentration of 40 mg mL −1 . Jin et al [ 50 ] designed a lipid‐modified floxuridine homomeric oligonucleotide (LFU20). The hydrophobic tail of a lipid could insert into the albumin core via hydrophobic interaction to form albumin protected LFU20 complex once LFU20 was intravenously injected, leading to better inhibition toward the tumor proliferation.…”

Section: Proteins As Carriers Of Drugs/photosensitizersmentioning

confidence: 99%

Protein‐Based Artificial Nanosystems in Cancer Therapy

Zhang

Mei

Guan

et al. 2020

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Proteins, like actors, play different roles in specific applications. In the past decade, significant achievements have been made in protein‐engineered biomedicine for cancer therapy. Certain proteins such as human serum albumin, working as carriers for drug/photosensitizer delivery, have entered clinical use due to their long half‐life, biocompatibility, biodegradability, and inherent nonimmunogenicity. Proteins with catalytic abilities are promising as adjuvant agents for other therapeutic modalities or as anticancer drugs themselves. These catalytic proteins are usually defined as enzymes with high biological activity and substrate specificity. However, clinical applications of these kinds of proteins remain rare due to protease‐induced denaturation and weak cellular permeability. Based on the characteristics of different proteins, tailor‐made protein‐based nanosystems could make up for their individual deficiencies. Therefore, elaborately designed protein‐based nanosystems, where proteins serve as drug carriers, adjuvant agents, or therapeutic drugs to make full use of their intrinsic advantages in cancer therapy, are reviewed. Up‐to‐date progress on research in the field of protein‐based nanomedicine is provided.

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“…The high binding affinity of lipoprotein to cellular scavenger receptor SR‐BI facilitates the interaction of cholesterol‐siRNA amphiphiles with the cell membrane. Similarly, octadecyl tails of amphiphilic DNA bound with albumin and the resulting aggregate was recognized by cell surface albumin receptors Gp18 and Gp30 …”

Section: Interactions Of Dna Amphiphiles and Their Assemblies With Cementioning

confidence: 99%

DNA Nanotechnology Enters Cell Membranes

Huo

Boersma

et al. 2019

Advanced Science

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DNA is more than a carrier of genetic information: It is a highly versatile structural motif for the assembly of nanostructures, giving rise to a wide range of functionalities. In this regard, the structure programmability is the main advantage of DNA over peptides, proteins, and small molecules. DNA amphiphiles, in which DNA is covalently bound to synthetic hydrophobic moieties, allow interactions of DNA nanostructures with artificial lipid bilayers and cell membranes. These structures have seen rapid growth with great potential for medical applications. In this Review, the current state of the art of the synthesis of DNA amphiphiles and their assembly into nanostructures are first summarized. Next, an overview on the interaction of these DNA amphiphiles with membranes is provided, detailing on the driving forces and the stability of the interaction. Moreover, the interaction with cell surfaces in respect to therapeutics, biological sensing, and cell membrane engineering is highlighted. Finally, the challenges and an outlook on this promising class of DNA hybrid materials are discussed.

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Floxuridine Homomeric Oligonucleotides “Hitchhike” with Albumin In Situ for Cancer Chemotherapy

Cited by 71 publications

References 33 publications

Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

Protein‐Based Artificial Nanosystems in Cancer Therapy

DNA Nanotechnology Enters Cell Membranes

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