2006
DOI: 10.1182/blood-2006-02-004234
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Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53

Abstract: Loss or mutation of the TP53 tumor suppressor gene is not commonly observed in acute myeloid leukemia (AML), suggesting that there is an alternate route for cell transformation. We investigated the hypothesis that previously observed Bcl-2 family member overexpression suppresses wild-type p53 activity in AML. We demonstrate that wild-type p53 protein is expressed in primary leukemic blasts from patients with de novo AML using 2-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and phospho-specific flow … Show more

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Cited by 72 publications
(58 citation statements)
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“…Flt3-mediated activation of downstream signaling pathways may thus stabilize the p53 full-length protein, and the p53 biosignature therefore reveal a high expression of the p53 full-length protein as observed (Figure 4). This also supports our observation that specific FLT3-ITD corresponds to p53 hyperphosphorylation (Irish et al, 2007). On the basis of these previous results, it appears that FLT3-ITD-driven p53 hyperphosphorylation is accompanied by a downstream block of p53 signaling through anti-apoptotic mechanisms (Irish et al, 2007).…”
Section: Discussionsupporting
confidence: 89%
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“…Flt3-mediated activation of downstream signaling pathways may thus stabilize the p53 full-length protein, and the p53 biosignature therefore reveal a high expression of the p53 full-length protein as observed (Figure 4). This also supports our observation that specific FLT3-ITD corresponds to p53 hyperphosphorylation (Irish et al, 2007). On the basis of these previous results, it appears that FLT3-ITD-driven p53 hyperphosphorylation is accompanied by a downstream block of p53 signaling through anti-apoptotic mechanisms (Irish et al, 2007).…”
Section: Discussionsupporting
confidence: 89%
“…Genetic changes in AML frequently alter signal transduction either directly or indirectly (Irish et al, 2004), subsequently reflected in posttranslational modifications of protein stress sensors and tumor suppressors like p53 (Irish et al, 2007). Given the complexity of p53 regulation including isoform expression and posttranslational modifications, p53 protein is hypothesized to integrate multiple sources of information about intracellular signaling with relevance for chemoresistance (Fridman and Lowe, 2003;Irish et al, 2007).…”
Section: Discussionmentioning
confidence: 99%
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“…The Bcl2 expression in AML has been studied by flow cytometry [5,[14][15][16][17][18][19], western blotting [20] and immnunocytochemistry [13,21,22] by various groups reporting heterogenous expression in the range of 34 to 87%. With clinical and hematological pa- Log Rank=1.00, df=1, P=0.31 *P value ≤ 0.05 is significant; DFS, Disease free survival; OS, Overall survival rameters, no significant correlation could be obtained.…”
Section: Discussionmentioning
confidence: 99%