Fluconazole Non Susceptible Disseminated Coccidioidomycosis in a Critically Ill Patient Without Known Immunosuppression

Eltayeb, Mohamed; Asad, Shadaba; Malik, Arhama; Cao, Yen; Yu, Wen Yuan; Hong, Annie

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a6871

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intrinsic azole activity is VCZ ~PCZ > ITZ (= AMB) >> FCZ (Thompson et al, 2017). Acquired resistance to azoles was reported in clinical isolates (Kriesel et al, 2008), but the amount of isolates with decreased sensitivity is still very low (Eltayeb et al, 2019;Thompson et al, 2017). However, based on the long exposure time (months to years) of C. immitis to azoles during human therapy, the evolution of acquired resistance in medicine is likely to occur.…”

Section: Clinically Relevant Filamentous and Dimorphic Fungal Speciesmentioning

confidence: 99%

Crossover between the control of fungal pathogens in medicine and the wider environment, and the threat of antifungal resistance

Gisi¹

2021

Plant Pathology

View full text Add to dashboard Cite

A primary human pathogen is an agent (fungus, bacterium, virus) causing any kind of disease in humans, either superficially or within the body (invasive, systemic). All fungal propagules (all kind of cells, spores) existing in the natural environment can be transmitted to the human body. Fungal infections usually start in the lung by inhalation of contaminated air, or on the skin, nails, and mucosa (vagina, mouth, sinuses) by direct contact (e.g., through wounds), and rarely also in the gastrointestinal tract by intake of contaminated food or water. Fungal infections in humans are rarely serious (lifethreatening) unless the patient's immune system is weakened, for

show abstract

Section: Clinically Relevant Filamentous and Dimorphic Fungal Speciesmentioning

confidence: 99%

Crossover between the control of fungal pathogens in medicine and the wider environment, and the threat of antifungal resistance

Gisi¹

2021

Plant Pathology

View full text Add to dashboard Cite

show abstract

Fatal septic shock due to disseminated coccidioidomycosis: a case series and review of the literature

et al. 2023

View full text Add to dashboard Cite

Background Coccidioidomycosis is a fungal infection endemic to the southwestern United States and regions of Latin America. Disseminated disease occurs in < 1% of cases. Septic shock is even rarer, with high mortality despite therapy. Case summary We describe two cases of coccidioidal septic shock. Both patients were older men of Filipino ancestry presenting with respiratory failure and vasopressor-dependent shock. Antifungal drugs were initiated after failure to improve with empiric antibiotics; in both, Coccidioides was isolated from respiratory cultures. Despite aggressive care, both patients ultimately died of their infections. We provide a review of the published literature on this topic. Conclusions Most of the 33 reported cases of coccidioidal septic shock occurred in men (88%) of non-white race and ethnicity (78%). The overall mortality rate was 76%. All survivors received amphotericin B as part of their treatment. Coccidioidomycosis-related septic shock is a rare disease with poor outcomes; delays in diagnosis and treatment are common. Improved diagnostic testing for coccidioidomycosis could enhance recognition of this disease in the future. Although data are limited, early treatment with amphotericin B in cases of coccidioidal septic shock may reduce mortality.

show abstract

Fluconazole Non Susceptible Disseminated Coccidioidomycosis in a Critically Ill Patient Without Known Immunosuppression

Cited by 2 publications

References 0 publications

Crossover between the control of fungal pathogens in medicine and the wider environment, and the threat of antifungal resistance

Crossover between the control of fungal pathogens in medicine and the wider environment, and the threat of antifungal resistance

Fatal septic shock due to disseminated coccidioidomycosis: a case series and review of the literature

Contact Info

Product

Resources

About