Fluconazole plasma concentration measurement by liquid chromatography for drug monitoring of burn patients

Santos, Sílvia Regina Cavani Jorge; Campos, Elaine Cristina de; Sanches, Cristina; Gómez, David S.; Ferreira, Marcus Castro

doi:10.1590/s1807-59322010000200017

Cited by 23 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies focusing specifically on burn patients are scarce, and no recommendation has been established regarding empirical initial doses of anti-infective agents in burn victims [10,[20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients

Fournier

Eggimann

Pagani

et al. 2015

Burns

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients

Fournier

Eggimann

Pagani

et al. 2015

Burns

View full text Add to dashboard Cite

“…Fluconazole [2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazole-1-yl)-2-propanol] [1] is mainly used as an antifungal antibiotic [2][3][4] (Figure 1) is and also used to prevent yeast infections in patients who are likely to become infected, because they are being treated with chemotherapy or radiation therapy before a bone marrow transplant. Several HPLC methods were reported for the analysis of fluconazole in pharmaceutical preparations and in body fluids as plasma, serum, and human urine sample [1,[5][6][7][8][9][10][11]. Few of GC and HPLC methods have been reported for the determination of fluconazole in biological fluids, eye drops, and creams [12].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Validation Study of Fluconazole by HPLC and UPLC with Forced Degradation Study

Jebaliya

Patel

Jadeja

et al. 2013

Chromatography Research International

View full text Add to dashboard Cite

The simplest stability indicating reversed phase Isocratic HPLC and UPLC methods has been developed and validated for the determination of fluconazole in bulk and solid pharmaceutical dosage form. A SunFire C18 (250 × 4.5 mm, 5 μm particle size) column has been used for HPLC and BEH C18 (100 × 2.1 mm, 1.7 μm particle size) column used for UPLC. The Mobile phase consisted of Methanol : Water (70 : 30) for HPLC and Methanol : Water (55 : 45 v/v) for UPLC. Isocratic flow was set at 1 mL/min and 0.30 mL/min, respectively, for HPLC and UPLC. For both HPLC and UPLC system detection has been performed at 211 nm with 30°C column oven temperature (good elution was obtained at 30°C) and injection volume, respectively, 2 μL and 20 μL for HPLC and UPLC.

show abstract

“…Com relação à farmacoterapia a ser instituída no controle das infecções em grandes queimados, os critérios recomendados estão documentados no "Guia de Utilização de Anti-infecciosos e Recomendações para a Prevenção de Infecções Hospitalares" são descritos a seguir no quadro 1 (HCFMUSP, 2009(HCFMUSP, -2011. Ressalta-se que a terapêutica sistêmica inicial desses agentes no caso de pacientes queimados tem registrado a necessidade da intervenção médica com relação à alteração do regime empírico inicial (SANTOS et al, 2010).…”

Section: Figura 2 -unclassified

“…O volume aparente de distribuição foi estimado através da razão entre a depuração plasmática e a constante de velocidade de eliminação. A literatura é escassa relativamente ao monitoramento plasmático e ajuste de dose do fluconazol em pacientes queimados (BOUCHER et al, 1998;RAYATT et al, 2000;SANTOS et al, 2010). Recomenda-se que a concentração plasmática mínima efetiva seja na ordem de 4µg/mL para a profilaxia antifúngica, na farmacoterapia da candidiase após dose diária de 100mg diários, entretanto o tratamento das infecções sistêmicas exige doses superiores que vão depender da função renal do paciente.…”

Section: Etapa Analíticaunclassified

See 1 more Smart Citation

Monitoramento terapêutico de fluconazol com suporte farmacocinético em pacientes grandes queimados com internação prolongada para controle das infecções fúngicas

Bragatto¹

View full text Add to dashboard Cite

The sepsis is a main cause of morbidity and mortality in burn patients, once pharmacokinetics of anti-infective drugs prescribed for the control of systemic infections are significantly altered in those patients. In addition, burn patients in the ICU, initially can present infections by community microbial and must receive different antimicrobials than those prescribed for sepsis. On the other hand, burn immunocompromized patients with prolonged staying in the ICU, re-incidence of sepsis and fungal infection requires an effective antifungal agent that must be associated to the antimicrobials prescription. The objective of the study was to therapeutic plasma monitoring of fluconazole largely prescribed to burn patients from the ICU with fungal infection, Pharmacokinetic modeling for dose adjustment and for the control of infection. Twelve burn inpatients with systemic fungal infections from the ICU Burns

show abstract

Fluconazole plasma concentration measurement by liquid chromatography for drug monitoring of burn patients

Cited by 23 publications

References 24 publications

Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients

Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients

A Comparative Validation Study of Fluconazole by HPLC and UPLC with Forced Degradation Study

Monitoramento terapêutico de fluconazol com suporte farmacocinético em pacientes grandes queimados com internação prolongada para controle das infecções fúngicas

Contact Info

Product

Resources

About