Fluconazole-Resistant Candida: Mechanisms and Risk Factor Identification

Dery, MarkAlain; Hasbun, Rodrigo

doi:10.1007/s12281-010-0045-3

Cited by 9 publications

(7 citation statements)

References 29 publications

(46 reference statements)

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“…On the other hand, as C. krusei , C. tropicalis and C. keyfr infections were found to be at higher rates in wards than in ICUs in our study, we believe that these data are important for the choice of empirical antifungal treatment. When the increase in the frequency of C. glabrata is considered, we know that there is controversy about the relationship between fluconazole usage and azole‐resistant Candida infections . In addition, some antibiotics were found to be a risk factor for different Candida species .…”

Section: Discussionmentioning

confidence: 99%

“…When the increase in the frequency of C. glabrata is considered, we know that there is controversy about the relationship between fluconazole usage and azoleresistant Candida infections. 27,28 In addition, some antibiotics were found to be a risk factor for different Candida species. 29 Unfortunately, we have no welldefined data for antifungal usage in our hospital.…”

Section: Discussionmentioning

confidence: 99%

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An investigation of Candida species isolated from blood cultures during 17 years in a university hospital

Kazak

Akın

Ener

et al. 2014

Mycoses

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Candidemia is the most frequent manifestation observed with invasive candidiasis. The aim of this study was to analyse the trends of candidemia in a large tertiary-care hospital to determine the overall incidence during January 1996-December 2012, as well as to determine the susceptibility of 453 isolates according to the revised Clinical and Laboratory Standards Institute (CLSI) breakpoints. Candidemia episodes in adult and paediatric patients were retrospectively analysed from the laboratory data of Uludağ University Healthcare and Research Hospital. The 17-year period studied was divided into three periods (1996-2001, 2002-2007 and 2008-2012) for better comparison, and candidemia incidence was determined by the ratio of total number of patients with candidemia per 1000 patients admitted to the hospital and per 10 000 patient days in these three periods. Redefined CLSI M27-A3 breakpoints were used for interpretation of antifungal susceptibility results. Candidemia incidence was determined as 2.2, 1.7 and 1.5 per 1000 admitted patients during 1996-2001, 2002-2007 and 2008-2012 respectively. A significantly decreased candidemia incidence was obtained in the third period. C. albicans (43.8%) was the most common candidemia agent, followed by C.parapsilosis (26.5%) in all three periods. According to the revised CLSI breakpoints, there was fluconazole resistance in C. albicans, C.parapsilosis, C.tropicalis and C.glabrata species (1.4%, 18.2%, 2.6% and 14.3% respectively). Almost all Candida species were found susceptible to voriconazole except one C.glabrata (7.1%) isolate. Candidemia is an important health problem. Local epidemiological data are determinative in the choice of appropriate antifungal treatment agents.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An investigation of Candida species isolated from blood cultures during 17 years in a university hospital

Kazak

Akın

Ener

et al. 2014

Mycoses

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“…Since the incidence of azole‐resistant yeast and fungus strains has been on the rise, it is important to investigate the susceptibility of probiotic yeast strains to azoles and consider alternative antifungal drugs (Verweij et al . ; Déry and Hasbun ). Further studies are required to identify antifungal agent(s) efficient in inhibiting S. unisporus growth.…”

Section: Discussionmentioning

confidence: 98%

Biochemical characteristics, virulence traits and antifungal resistance of two major yeast species isolated from kefir: Kluyveromyces marxianus and Saccharomyces unisporus

Lim

Kim

Jeong

et al. 2019

Int J of Dairy Tech

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Kefir yeasts were investigated for their possible virulence using an in vitro system. Unweighted pair group method with arithmetic mean (UPGMA) cluster analysis of 46 biochemical traits showed that all kefir isolates formed clusters distinct from Candida albicans. No isolate showed N‐acetylglucosaminidase activity, which is involved in resistance against host immune systems. All Kluyveromyces marxianus isolates formed pseudohyphae and grew at 42 °C, whereas Saccharomyces unisporus isolates did not. None of the kefir yeasts had proteolytic or haemolytic activities. All K. marxianus isolates were susceptible to fluconazole, whereas S. unisporus isolates were classified as resistant.

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“…Fluconazole (FLZ, 2-(2,4-difluorophenyl)-1,3- bis (1H-1,2,4-triazol-1-yl)propan-2-ol) is one of the most widespreadly used antifungal agents (Charlier et al ., 2006 ; Dery and Hasbun, 2011 ). Owing to its excellent pharmacokinetics, spectrum of activity, bioavailability, low toxicity and lack of interaction with other drugs, fluconazole has so far been used to treat more than 100 million people in the world (Charlier et al ., 2006 ; Dery and Hasbun, 2011 ; Sabatelli et al ., 2006 ; Löffler et al ., 1997 ).…”

Section: Introductionmentioning

confidence: 99%

Activity of fluconazole and its Cu(II) complex towards Candida species

et al. 2014

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Candida species, although they are present as commensal organisms in the digestive tract of healthy individuals, can produce a broad spectrum of serious illnesses in compromised hosts. Fluconazole, a water-soluble triazole with bioavailability greater than 90 %, has been extensively used to treat a wide range of Candida infections. However, a growing resistance of microorganisms in the treatment leads to the discovery of new drugs or modifications of existing ones. The aim of the present study was to investigate whether coordination of Cu(II) ions to fluconazole affects its antifungal activity. The in vitro susceptibility tests and antifungal studies were performed with two Candida spp.: Candidaglabrata and Candida albicans. Overall, 34 strains of the former and 16 strains of the latter were treated with fluconazole, its Cu(II) complex and free Cu(II) ions. The obtained MIC values in 16 cases of the C. glabrata and in 5 cases of the C. albicans were lower for the complex in comparison to the drug. This implies that the complex is more effective against particular strains than the parent drug. The most significant improvement in the complex drug efficacy was observed for fluconazole-resistant species.Electronic supplementary materialThe online version of this article (doi:10.1007/s00044-014-1275-7) contains supplementary material, which is available to authorized users.

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Fluconazole-Resistant Candida: Mechanisms and Risk Factor Identification

Cited by 9 publications

References 29 publications

An investigation of Candida species isolated from blood cultures during 17 years in a university hospital

An investigation of Candida species isolated from blood cultures during 17 years in a university hospital

Biochemical characteristics, virulence traits and antifungal resistance of two major yeast species isolated from kefir: Kluyveromyces marxianus and Saccharomyces unisporus

Activity of fluconazole and its Cu(II) complex towards Candida species

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