Fluconazole

Jura, Sibyl E.; Hillenbrand, Karin

doi:10.1542/pir.27.4.158

Cited by 1 publication

(2 citation statements)

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“…This compound blocks the yeast-to-hypha transition and reduces the cellular surface hydrophobicity of the biofilm cells [75]. Ctn [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34], the C-terminal fragment of crotalicidin, an antimicrobial peptide from the rattlesnake Crotalus durissus terrificus venom, displayed antifungal activity towards C. albicans. Both referent and fluconazole resistant C. albicans, in planktonic or biofilm form of growth, were susceptible to the peptide application.…”

Section: Tackling Different Virulence Aspects-targeting Biofilm and H...mentioning

confidence: 99%

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Emerging Antifungal Targets and Strategies

Ivanov

Ćirić

Stojković

2022

IJMS

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Despite abundant research in the field of antifungal drug discovery, fungal infections remain a significant healthcare burden. There is an emerging need for the development of novel antifungals since those currently available are limited and do not completely provide safe and secure protection. Since the current knowledge regarding the physiology of fungal cells and the infection mechanisms is greater than ever, we have the opportunity to use this for the development of novel generations of antifungals. In this review, we selected and summarized recent studies describing agents employing different antifungal mechanisms. These mechanisms include interference with fungal resistance, including impact on the efflux pumps and heat shock protein 90. Additionally, interference with virulence factors, such as biofilms and hyphae; the impact on fungal enzymes, metabolism, mitochondria, and cell wall; and antifungal vaccines are explored. The agents investigated belong to different classes of natural or synthetic molecules with significant attention given also to plant extracts. The efficacy of these antifungals has been studied mainly in vitro with some in vivo, and clinical studies are needed. Nevertheless, there is a large quantity of products employing novel antifungal mechanisms that can be further explored for the development of new generation of antifungals.

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Section: Tackling Different Virulence Aspects-targeting Biofilm and H...mentioning

confidence: 99%

“…It can also be used in the treatment of fungal skin diseases and is especially effective in vaginal candidiasis. Its toxicity is far less than that of miconazole and ketoconazole [ 29 ].…”

Section: Current Antifungals In Use and Their Limitationsmentioning

confidence: 99%