Fluctuation of Bacteria on Bleb Surface After Trabeculectomy With Adjunctive Mitomycin C

Takahashi, Nobumichi; Sawada, Akira; Mochizuki, Kiyofumi; Katada, Toshihiko; Yamamoto, Tetsuya

doi:10.1097/ijg.0000000000000305

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…Because new quinolones are currently the main antibiotic agents used after ophthalmologic surgery, we selected articles with a high level of evidence that covered cases after 2000, when new quinolones were launched, owing to the nature of setting guidelines for the next several years. The only relevant studies were the four reports [243][244][245][246] that analyzed the use of antibiotic agents in 104 eyes with bleb-related infection in a nationwide survey of bleb-related infection conducted by the Japan Glaucoma Society. This study is a prospective, large-scale study of Japanese patients, in which most patients (40 of 42 eyes in the long-term use group) were using new quinolone antibiotics.…”

Section: Strength Of Evidence For Cqmentioning

confidence: 99%

“…Long-term use of antibiotics may lead to changes in the conjunctival microflora and the appearance of resistant bacteria. In a study of resistant strains toward new quinolone antibiotic agents on the surface of filtration bleb after trabeculectomy, there was no significant difference in culture positivity between eyes with and without long-term antibiotic use [245]. In 26 eyes with long-term use of new quinolone antibiotics, resistant bacteria were found in nine eyes, of which six were Staphylococcus epidermidis [246], which makes endophthalmitis less likely to become severe.…”

Section: Strength Of Evidence For Cqmentioning

confidence: 99%

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The Japan Glaucoma Society guidelines for glaucoma 5th edition

et al. 2023

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We are pleased to bring you the 5th edition of the Glaucoma Clinical Practice Guidelines. Clinical practice guidelines are based on evidence (scientific grounds). It is a document that presents the treatment that is the most appropriate for the patient. "Glaucoma Clinical Guidelines" was first published in 2003. This was the first guideline for glaucoma treatment in Japan. The principle of glaucoma treatment is to lower intraocular pressure. Means for lowering intraocular pressure includes drugs, lasers, and surgery; Glaucoma is a disease that should be considered as a complex syndrome rather than a single condition. Therefore, the actual medical treatment is not as simple as one word. This time we set the Clinical Questionnaire with a focus on glaucoma treatment. We hope that you will take advantage of the 5th edition.

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Section: Strength Of Evidence For Cqmentioning

confidence: 99%

Section: Strength Of Evidence For Cqmentioning

confidence: 99%

The Japan Glaucoma Society guidelines for glaucoma 5th edition

et al. 2023

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“…The association with gender is not clearly proven. Seasonal variation in temperature and humidity may influence the conjunctival flora and therefore, the rate of BRI [53].…”

Section: Risk Factorsmentioning

confidence: 99%

Post-Operative Infections Following Glaucoma Drainage Surgery

Ansari¹

2023

Eye Diseases - Recent Advances, New Perspectives and Therapeutic Options

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Glaucoma drainage surgery is performed commonly throughout the world for the surgical treatment of glaucoma. Typically, a guarded fistula is fashioned leading to a drainage bleb that represents subconjunctival collection and egress of aqueous humour from the eye. Bleb related infections (BRI) include blebitis and bleb related endophthalmitis (BRE). Although rare, BRI can be blinding, and appropriate vigilance is needed to ensure prompt diagnosis and treatment to save sight. Pre-operatively, blepharoconjunctivitis must be treated as well as any potential sources of infection. Clinicians must examine thoroughly to exclude bleb leaks and conjunctival erosions post-operatively. Patients must be educated about seeking care immediately if ocular redness, pain, discharge, or decreased vision develops. If BRI is diagnosed, sampling of ocular tissues is necessary for culture and sensitivity, followed by administration of broad-spectrum antibiotics. The interval from onset of symptoms to treatment, initial visual acuity, clarity of cornea at presentation, type of infecting organism, and presence or absence of diabetes mellitus are associated with final visual outcome particularly for BRE.

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“…When trying to determine the effect that glaucoma has on the VR-QOL, the VFQ-25 is frequently used to track the outcome. Previous studies that examined the VFQ-25 reported it to be useful, sensitive, and specific when investigating relationships between the VF disturbance due to glaucoma and the QOL in glaucoma patients [4–9]. …”

Section: Introductionmentioning

confidence: 99%

Vision-related quality of life following glaucoma filtration surgery

et al. 2017

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BackgroundTo evaluate vision-related quality of life (VR-QOL) following glaucoma filtration surgery.MethodsA total of 103 glaucoma patients scheduled to undergo glaucoma filtration surgery. Prior to and at three months after glaucoma filtration surgery, trabeculectomy or EX-PRESS, all patients completed the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). A total of 48 patients underwent combined cataract and filtration surgery. The clinical data collected pre- and postoperatively included best-corrected visual acuity (BCVA) and intraocular pressure (IOP).ResultsThe IOP decreased significantly from 19.0 ± 8.1 mmHg to 9.7 ± 3.9 mmHg (P < 0.001). Preoperative VFQ-25 composite score (65.8 ± 15.6) was similar to the postoperative score (67.8 ± 16.6). A significantly improved VFQ-25 composite score (pre: 63.2 ± 17.1, post: 67.7 ± 17.8; P = 0.001) was observed in the patients who underwent combined cataract and filtration surgery. There was a significant association between the BCVA changes in the operated eye and the changes in the VFQ-25 composite score (r = −0.315, P = 0.003).ConclusionsAlthough glaucoma filtration surgery by itself did not decrease the VR-QOL in glaucoma patients, there was significant improvement in the VR-QOL after the patients underwent combined cataract and glaucoma filtration surgery.

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Fluctuation of Bacteria on Bleb Surface After Trabeculectomy With Adjunctive Mitomycin C

Abstract: It is not rare to detect the bacterial organisms on the bleb surface in glaucomatous eyes that had undergone trabeculectomy. The prevalence varied with the season and was highest in the autumn.

Cited by 4 publications

References 33 publications

The Japan Glaucoma Society guidelines for glaucoma 5th edition

The Japan Glaucoma Society guidelines for glaucoma 5th edition

Post-Operative Infections Following Glaucoma Drainage Surgery

Vision-related quality of life following glaucoma filtration surgery

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