Fluctuations in Antibody Levels in Infection With Treponema Pertenue.

Reid, Malcolm S.; Talwat, E.; McNamara, Keelan; Garner, M. F.

doi:10.1111/j.1440-0960.1983.tb00255.x

Cited by 7 publications

(1 citation statement)

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“…Following mass treatment, however, the number of reported cases declined significantly, to the point that yaws was considered eliminated in most areas (242,243). Since the late 1970s, however, reports of suspected cases of yaws from several areas of Papua New Guinea (244)(245)(246)(247)(248)(249)(250), the Solomon Islands (242,(251)(252)(253), and Vanuatu (254,255) started to appear in the literature, suggesting that elimination was not achieved. In 2011, Papua New Guinea reported 34,628 yaws cases, followed by the Solomon Islands (20,635 cases in 2010) and Vanuatu (1,574 cases in 2010) (240) ( Table 2).…”

Section: Yawsmentioning

confidence: 99%

The Endemic Treponematoses

2014

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SUMMARY The agents of human treponematoses include four closely related members of the genus Treponema : three subspecies of Treponema pallidum plus Treponema carateum . T. pallidum subsp. pallidum causes venereal syphilis, while T. pallidum subsp. pertenue , T. pallidum subsp. endemicum , and T. carateum are the agents of the endemic treponematoses yaws, bejel (or endemic syphilis), and pinta, respectively. All human treponematoses share remarkable similarities in pathogenesis and clinical manifestations, consistent with the high genetic and antigenic relatedness of their etiological agents. Distinctive features have been identified in terms of age of acquisition, most common mode of transmission, and capacity for invasion of the central nervous system and fetus, although the accuracy of these purported differences is debated among investigators and no biological basis for these differences has been identified to date. In 2012, the World Health Organization (WHO) officially set a goal for yaws eradication by 2020. This challenging but potentially feasible endeavor is favored by the adoption of oral azithromycin for mass treatment and the currently focused distribution of yaws and endemic treponematoses and has revived global interest in these fascinating diseases and their causative agents.

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Section: Yawsmentioning

confidence: 99%

The Endemic Treponematoses

2014

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Bakterielle Erkrankungen

Braun‐Falco¹,

Plewig²,

Wolff³

1996

Dermatologie Und Venerologie

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Yaws in West Sumatra, Indonesia: Clinical manifestations, serological findings and characterisation of new Treponema isolates by DNA probes

Noordhoek

Engelkens

Judanarso

et al. 1991

Eur. J. Clin. Microbiol. Infect. Dis.

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The results of a yaws survey on the island of Sumatra in Indonesia are presented. The prevalence of yaws in the investigated region was found to be very high, a minimum of 300 cases per 100,000 individuals, which indicates that yaws is far from being eradicated and that campaigns for treatment are necessary. Patients suffering from early infectious yaws showed florid skin lesions. Of 101 serum samples from such patients, 100 had a positive reaction in one or more treponemal tests. The Treponema pallidum haemagglutination assay was found to be the most sensitive test (97% positive) in detecting antibodies against Treponema pallidum subsp. pertenue, followed by the fluorescent treponemal antibody absorption test (94%), the Venereal Disease Research Laboratory test and the TmpA enzyme immunoassay (91%), and analysis by Western blot using Treponema pallidum antigens (88%). Of 42 asymptomatic contacts of yaws patients 32 showed positive reactions in one or more tests, indicating that many people in the investigated region have been infected with treponemes. Eight new Treponema pallidum subsp. pertenue strains were isolated from yaws skin lesions. In vitro amplification of treponemal DNA and hybridisation with specific DNA probes showed that all eight strains were identical with Treponema pallidum subsp. pertenue CDC 2575, with regard to the subsp. pertenue specific tyfl gene.

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Fluctuations in Antibody Levels in Infection With Treponema Pertenue.

Cited by 7 publications

References 1 publication

The Endemic Treponematoses

The Endemic Treponematoses

Bakterielle Erkrankungen

Yaws in West Sumatra, Indonesia: Clinical manifestations, serological findings and characterisation of new Treponema isolates by DNA probes

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