Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment &amp; Children's Study of a pilot cohort

Irahara, Makoto; Yamamoto‐Hanada, Kiwako; Saito‐Abe, Mayako; Sato, Miori; Miyaji, Yoshiyuki; Yang, Limin; Mitsubuchi, Hiroshi; Oda, Masako; Sanefuji, Masafumi; Ohga, Shouichi; Ikegami, Akihiko; Mise, Nathan; Suga, Reiko; Shimono, Masayuki; Yamazaki, Shin; Nakayama, Takeo; Ohya, Yukihiro

doi:10.1016/j.alit.2022.01.002

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…Serum levels of egg white (EW)- and CM-specific IgE and IgG4 were measured when the study participants were 2 years old using a densely carboxylated protein microarray (AMERIC, Tokushima, Japan) [ 32 , 33 , 34 , 35 ]. EW- and CM-specific IgE levels measured using this method correlate with the allergen-specific IgE levels measured using the ImmunoCAP system (Phadia, Uppsala, Sweden).…”

Section: Methodsmentioning

confidence: 99%

Relationship between Food Allergy and Endotoxin Concentration and the Toleration Status at 2 Years: The Japan Environment and Children’s Study

et al. 2023

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Changes in household endotoxin concentration may affect the prognosis of food allergy (FA), but data on the association between household endotoxin concentration and an already-developed FA are scarce. Thus, we investigated the association between environmental endotoxin exposure and tolerance to hen’s egg (HE) and cow’s milk (CM) using data from children participating in the Japan Environment and Children’s Study who had HE allergies (n = 204) and CM allergy (n = 72) in their first year of life. We grouped the endotoxin results into quartiles 1–4 (Q1–Q4). In children with HE allergy and with CM allergy, there was no significant difference in the prevalence of tolerance to HE and CM at 2 years old when comparing endotoxin levels of the children in Q1 with those in Q2, Q3, and Q4, respectively. However, subgroup analyses by the presence of eczema and causal foods revealed that children in Q1 had a lower prevalence of tolerance to foods in some subgroup analyses and lower causal allergen-specific immunoglobulin G4 levels. Although an individually based approach against endotoxin according to background characteristics, such as eczema and causal foods, is necessary, preventing excessive endotoxin removal might contribute to FA resolution in some children.

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Section: Methodsmentioning

confidence: 99%

Relationship between Food Allergy and Endotoxin Concentration and the Toleration Status at 2 Years: The Japan Environment and Children’s Study

et al. 2023

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“…Allergen-specific IgE titers in serum samples of the participating children at 6 years of age were measured using the densely carboxylated protein microarray (AMERIC, Tokushima, Japan) and were reported as binding unit of IgE (BUe)/mL [ 7 , 8 ]. Allergen-specific IgE titers were measured for 19 aeroallergen including house dust mite, Dermatophagoides farinae , [Der f 1], Dermatophagoides pteronyssinus , [Der p 1], dog dander, cat dander, the fungi Ascomycota , Alternaria alternata : [Alt a 1], Aspergillus fumigatus : [Asp f 1], and Cladosporium herbarum : [Cla h 8], Japanese cedar, Cryptomeria japonica : [Cry j 1], Japanese cypress, birch, alder, timothy grass, sweet vernal grass, orchard grass, and ragweed.…”

Section: Methodsmentioning

confidence: 99%

Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort

Miyaji,

Yamamoto-Hanada,

Yang

et al. 2023

BMC Pediatr

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Background Numerous studies suggest that sex steroids might play a role in sex disparity observed in allergic diseases in adults. However, whether sex hormones influence allergic diseases in children remains unclear. The aim of the present study was to examine the association of sex steroid hormones with allergic disease in Japanese children. Methods The present cross-sectional study included 145 6-year-old children participating in a pilot birth cohort study in the Japan Environment and Children’s Study. Data on allergic diseases were obtained from questionnaires, and serum levels of sex steroid hormones and allergen-specific IgE were measured. Logistic regression was performed to evaluate the association of sex hormones with allergic diseases. Results After adjusted sex, amount of body fat at 6 years, parental history of allergic disease, and exposure to tobacco smoke, serum dehydroepiandrosterone sulfate level was significantly associated with reduced odds of any allergic disease (adjusted odds ratio, 0.58; 95% confidence interval, 0.36–0.93; P = 0.024) and serum follicle-stimulating hormone level was significantly associated with increased odds of any allergic disease (adjusted odds ratio, 2.04; 95% confidence interval, 1.01–4.11, P = 0.046). Dehydroepiandrosterone sulfate level showed a significant association with number of allergic diseases. Conclusions The current study findings suggest that sex hormones may play an important role in the development of allergic diseases in prepubertal children.

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“…We selected Der f 1, the relatively common target of HDM-specific IgE in children, 34 to examine the association between endotoxin concentration and HDM-specific immunoglobulin levels. To measure the IgE, IgG1, IgG4, and IgA levels in sera from the children at age 2 years, we used a densely carboxylated protein microarray (AMERIC), [35][36][37][38] which has a correlation of allergen-specific immunoglobulin levels with the ImmunoCAP system (Phadia). The measurement limit values of the Der f 1-specific immunoglobulins were 0.01 BUe/mL for IgE, 100.0 BUg1/mL for IgG1, 50.0 BUg4/mL for IgG4, and 2.5 BUa/mL for IgA.…”

Section: Measurement Of Der F1-specific Ige Igg1 Igg4 and Iga Levelsmentioning

confidence: 99%

Endotoxin concentration and persistent eczema in early childhood

Irahara

Yamamoto‐Hanada

Sato

et al. 2022

The Journal of Dermatology

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Atopic dermatitis (AD) is a common disease characterized by chronic inflammation and pruritus of the skin. [1][2][3][4] In many cases, AD develops before the age of 2 years, and children participating in several studies exhibited one of two trajectories of AD: (1) early development and early improvement, and (2) early development and persistence. [5][6][7] Children with persistent AD, in particular, have a long clinical course, increased use of medication, and poor quality of life, manifested by symptoms such as sleep disturbance caused by itchy rash. 1,3,[8][9][10] In

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Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort

Cited by 5 publications

References 44 publications

Relationship between Food Allergy and Endotoxin Concentration and the Toleration Status at 2 Years: The Japan Environment and Children’s Study

Relationship between Food Allergy and Endotoxin Concentration and the Toleration Status at 2 Years: The Japan Environment and Children’s Study

Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children’s Study cohort

Endotoxin concentration and persistent eczema in early childhood

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