2005
DOI: 10.1074/jbc.m409897200
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Fluctuations of Intracellular Iron Modulate Elastin Production

Abstract: Production of insoluble elastin, the major component of elastic fibers, can be modulated by numerous intrinsic and exogenous factors. Because patients with hemolytic disorders characterized with fluctuations in iron concentration demonstrate defective elastic fibers, we speculated that iron might also modulate elastogenesis. In the present report we demonstrate that treatment of cultured human skin fibroblasts with low concentration of iron 2-20 M (ferric ammonium citrate) induced a significant increase in the… Show more

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Cited by 36 publications
(34 citation statements)
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“…2 elastic fibers both at the transcriptional and protein synthesis levels. 40 Even if the effect of iron on elastic fibers might contribute to the elastopathy of ␤-thalassemia, it can hardly explain the complete clinical and structural similarities of the symptoms with inherited PXE. In fact, in hereditary hemochromatosis, whether in human patients or a mouse model, no ectopic calcification of the connective tissue has been reported.…”
Section: Discussionmentioning
confidence: 99%
“…2 elastic fibers both at the transcriptional and protein synthesis levels. 40 Even if the effect of iron on elastic fibers might contribute to the elastopathy of ␤-thalassemia, it can hardly explain the complete clinical and structural similarities of the symptoms with inherited PXE. In fact, in hereditary hemochromatosis, whether in human patients or a mouse model, no ectopic calcification of the connective tissue has been reported.…”
Section: Discussionmentioning
confidence: 99%
“…The observed lack of mature elastin structures thus constitutes a serious limitation for tissue engineering of functional blood vessels designed for the high-pressure circulation. Biosynthesis and subsequent crosslinking of elastin appears to be one of the most complex and tightly regulated processes during the maturation of blood vessels [49].…”
Section: Synthetic Scaffoldsmentioning
confidence: 99%
“…Numerous studies have been aimed at reversal of damaged skin (reviewed in Mahoney et al, 2009). We described that a proteolytic digest of elastin and iron (ferric ammonium citrate) (Bunda et al, 2005) can stimulate production of tropoelastin in skin and that polyphenols (tannic acid and ellagic acid; Jimenez et al, 2006) that preferentially bind to elastin protect it from proteolysis. Stimulation of new elastic fibers in the skin has also been reported after topical treatment with 17-b-estradiol (Son et al, 2005).…”
Section: Introductionmentioning
confidence: 98%