Fluctuations of plasma liproprotein-a concentrations during pregnancy and post partum

Zechner, Rudolf; Desoyé, Gernot; Schweditsch, M.; Pfeiffer, Karl P.; Kostner, Gerhard M.

doi:10.1016/0026-0495(86)90150-2

Cited by 91 publications

(30 citation statements)

References 14 publications

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“…Subsequently, a high Lp(a) concentration was seen in a family with severe preeclampsia (115), focusing attention on the relation be tween Lp(a) and pregnancy. A longitudinal study reported an increase in Lp(a) levels during the first trimester, reaching its maximum in the middle of the second trimes ter, approximately 3fold higher than levels at eight weeks, before returning to baseline levels at birth (116). Similar cytokines were elevated as well.…”

Section: Pregnancymentioning

confidence: 94%

Lipoprotein (a): impact by ethnicity and environmental and medical conditions

Enkhmaa

Anuurad

Berglund

2016

Journal of Lipid Research

190

134

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Section: Pregnancymentioning

confidence: 94%

Lipoprotein (a): impact by ethnicity and environmental and medical conditions

Enkhmaa

Anuurad

Berglund

2016

Journal of Lipid Research

190

134

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“…13 However, nonspecific receptor pathways have also been suggested. 5 -6 centrations increase in early pregnancy 15 and decrease after administration of norethisterone 16 or anabolic steroids. 17 A role for gonadal steroids in the regulation of Lp(a) has recently been emphasized by the marked effect of estrogen treatment and orchidectomy on Lp(a) concentrations in men with prostatic carcinoma.…”

mentioning

confidence: 99%

Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations.

Edén

Wiklund

Oscarsson

et al. 1993

Arterioscler Thromb

211

108

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The effects of growth hormone treatment of adults with adult-onset pituitary insufficiency on lipoproteins and apolipoproteins were investigated. Nine patients, one women and eight men (age range, 34-58 years), who had been treated for pituitary tumors were studied. They had complete pituitary insufficiency with a duration of at least 1 year. All patients received replacement therapy with thyroid hormones, glucocorticoids, and gonadal steroids. The study had a double-blind, placebo-controlled, crossover design for active treatment with recombinant human growth hormone (0.25-0.5 units/kg per week s.c given each evening) for 6 months. Fasting serum levels of cholesterol; triglycerides; high density lipoprotein and low density lipoprotein cholesterol; apolipoproteins A-I, B, and E; and lipoprotein (a) were measured before and after 6 and 26 weeks of treatment Lipoprotein (a) concentrations increased markedly during treatment and were about twice as high compared with pretreatment levels. Serum cholesterol and low density lipoprotein cholesterol concentrations were decreased after 6 weeks of treatment, but levels had returned to pretreatment levels after 26 weeks. High density lipoprotein cholesterol concentrations increased during treatment and were significantly higher than pretreatment levels after 26 weeks of treatment Serum trigiyceride concentrations did not change significantly, but in two patients with marked hypertriglyceridemia, growth hormone treatment resulted in a marked decrease. Serum concentrations of apolipoproteins A-I, B, and E did not change significantly, but changes in apolipoprotein A-I and B concentrations were in parallel to those observed for high density lipoprotein cholesterol and low density lipoprotein cholesterol, respectively. These results suggest that growth hormone is a major regulator of lipoprotein metabolism and also demonstrate that lipoprotein (a) concentrations are regulated by growth hormone. (Arteriosclerosis and Thrombosis 1993;13:296-301) KEY WORDS • lipoproteins • growth hormone • hypopituitarism F ew human studies have been performed on the effects of growth hormone (GH) on the different lipoprotein fractions and apolipoprotein levels. Moreover, studies on the effects of GH on the regulation of serum lipid levels have given conflicting results. However, both GH excess, as in acromegaly, 1 and deficiency 2 result in an increased risk of death due to cardiovascular disorders, which might indicate a role for GH in the control of lipoprotein metabolism in humans.Several recent publications have reviewed the genetics, biochemistry, and possible role in arteriosclerosis and thrombogenesis of lipoprotein (a) (Lp[a]). 3~6 The plasma concentration of Lp(a) is mainly genetically From the Department of Physiology (S.E., J.O.), the

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“…pregnancy (7,(10)(11)(12)(13)(14), under the influence of drugs (19,25), oral contraceptives (17) and hormones (19,26,27), including gonadotropins (15,16). Results from animal studies (28) cannot be compared directly with results from humans (5) without due consideration of animal physiology.…”

Section: Resultsmentioning

confidence: 99%

“…dependent risk factor for early onset atherosclerotic changes (1)(2)(3)(4), relatively little is known about factors The results presented in this article have been derived influencing its concentration in blood. Conflicting re-from over three years of observations using a single lot ports about changes in lipoprotein(a) concentrations in of reagents, thus excluding variation due to methodolserum in response to hormonal activity may be due to ogy and changing reagents and calibration materials, several conditions, including the size of the group j^ hypothesis that lipoprotein(a) concentrations may studied (5,6), the time-period of observation (6,7), the be a ff ec ted by gonadotropins has been examined using method used for quantitation (8), and the statistics used observations made in this hospital as well as from those for comparison (9).…”

Section: Introductionmentioning

confidence: 99%

Do Gonadotropins Influence Serum Lipoprotein(a) Concentrations? Observations on Children, Adolescents and Adults

Schumacher¹,

Weigert²,

Wood³

1996

CCLM

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Summary:Data from 7045 subjects were examined. The main groups consisted of the following in-and outpatients: 1414 neonates, 2554 children and adolescents (1336 males, 1218 females), 1209 women directly postpartum, 786 non-pregnant women and 1090 men aged between 18 and 100 years of age. Unless otherwise stated, persons were under medical observation or therapy.The results were obtained over a three-year period using an in-house immunolurninometric assay specific for apolipoprotein(a) using two polyclonal antibodies and a single lot of reagents to allow for comparability of results.Girls aged between 10 and 12 years of age had significantly higher serum lipoprotein(a) (median 124 mg/1) levels than boys (median 88 mg/1) of the same age (p < 0.05 -Mann-Wliitney U-test). Post-pubertal lipoprotein(a) concentrations were not significantly different from pre-pubertal levels. Between the ages of 0-9 and 13-17 years there were no statistically significant sex-linked differences in serum lipoprotein(a).In adults, lipoprotein(a) serum levels were significantly higher in women (median 163 mg/1) aged between 50 and 59 years, when compared with men (median 128 mg/1) of the same age group (p = 0.05 -Kruskal-Wallis one way ANOVA followed by the Nemenyi test).There was no significant difference in serum lipoprotein(a) concentrations between healthy women (median 91 mg/1), women direct postpartum (median 116 mg/1) and in-patient women (median 117 mg/1) aged between 18 and 41 years of age (p = 0.11-0.96). There was no correlation between maternal lipoprotein(a) and birth weight in mature newborns (r = -0.028-0.085).The results may indicate a direct influence of gonadotropins at puberty and during the menopause which cause an increase in serum lipoprotein(a) concentrations.

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Fluctuations of plasma liproprotein-a concentrations during pregnancy and post partum

Cited by 91 publications

References 14 publications

Lipoprotein (a): impact by ethnicity and environmental and medical conditions

Lipoprotein (a): impact by ethnicity and environmental and medical conditions

Growth hormone treatment of growth hormone-deficient adults results in a marked increase in Lp(a) and HDL cholesterol concentrations.

Do Gonadotropins Influence Serum Lipoprotein(a) Concentrations? Observations on Children, Adolescents and Adults

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