Fluctuations of Resting Neural Membrane Potential

Derksen, H. E.; Verveen, A. A.

doi:10.1126/science.151.3716.1388

Cited by 99 publications

(53 citation statements)

References 13 publications

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“…In addition to thermal noise, the membrane voltage was found to contain a large excess noise of the 1// type in the range of frequencies from o-i to 10 000 Hz. Compelling evidence suggested that the 1// noise was mainly associated with the passive movement of potassium ions, and this result was confirmed by later experiments on the same preparation (Derksen & Verveen, 1966;Verveen & Derksen, 1968;Siebenga & Verveen, 1970) and also on giant axons of lobsters (Poussart, 1971). A detailed discussion of 1//noise in nerve membranes is given by Verveen & De Felice (1974).…”

Section: Early Studies (1 If Noise and Burst Noise)supporting

confidence: 56%

“…Particularly in the field of electronics the minimization of noise for the purpose of optimizing measuring devices was the major task of fluctuation analysis. Also the initial studies of electrical noise in nerve membranes (Derksen, 1965.;Derksen & Verveen 1966;Verveen & Derksen, 1968) aimed merely at the understanding of, and accounting for, the disturbances produced by spontaneous fluctuations in the operation of the nervous system. The effects of membrane noise on thresholds, latencies, generator potentials, etc.…”

mentioning

confidence: 99%

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Channel noise in nerve membranes and lipid bilayers

Conti

Wanke

1975

Quart. Rev. Biophys.

162

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The basic principles underlying fluctuation phenomena in thermodynamics have long been understood (for reviews see Kubo, 1957; Kubo, Matsuo & Kazuhiro 1973 Lax, 1960). Classical examples of how fluctuation analysis can provide an insight into the corpuscular nature of matter are the determination of Avogadro's number according to Einstein's theory of Brownian motion (see, e.g. Uhlenbeck & Ornstein, 1930; Kac, 1947) and the evaluation of the electronic charge from the shot noise in vacuum tubes (see Van der Ziel, 1970).

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Section: Early Studies (1 If Noise and Burst Noise)supporting

confidence: 56%

mentioning

confidence: 99%

Channel noise in nerve membranes and lipid bilayers

Conti

Wanke

1975

Quart. Rev. Biophys.

162

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“…The spectra then declined at approximately a 1/f slope, with a magnitude that was still in excess of the thermal level. Noise of the 1/f type has been reported in two axons (14,15), as well as in the squid axon (4). Furthermore, if the residual 1/f spectrum (after addition of Et4N+) is graphically removed from the control spectra, each spectrum V2/Hz level is indicated.…”

Section: Resultsmentioning

confidence: 99%

Relaxation Spectra of Potassium Channel Noise from Squid Axon Membranes

Fishman¹

1973

Proc. Natl. Acad. Sci. U.S.A.

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Power density spectra of electrical fluctuations in potential and current (during voltage clamp) Two general classes of models for conducting channels in squid axon membrane follow from the Hodgkin-Huxley (1) description of the ion current flow. The first of these, the twostate channel conductance, was suggested by them as a possible interpretation of their data. In these models their parameters m, n, and h represent the probability that a channel gate, consisting of subunits, is either in a position that allows ion passage (open configuration) or in a position that completely prevents it (closed configuration). 40-75,um) was placed in contact with the axon and filled with sea water. An electrically floating platinized-platinum wire (25 Mm/diameter) within the length of the inner pipette acted as an ac shunt to the sea water and lowered the equivalent resistance of the pipette (i.e., access resistance to the patch) to less than 30 ko (5). This pipette was mounted in a plexiglass holder filled with sea water in which two electrodes were placed-one for applying current and the other for measuring potential.The outer pipette (tip diameter, 200-300 Mm) was shorter than the inner by 300-400 Mum, and directed the flow of isosmotic sucrose solution (0.8 M) over the ring of axon surrounding the membrane area within the aperture of the inner pipette. The sucrose flow was very slow (one drop every 30 sec) and was swept out of the chamber (6) by flowing sea water, which was directed normal to the long axis of the axon. The solution in the chamber was grounded through a platinized-silver electrode.Axons were internally perfused as described (6). The standard internal perfusate was 0.5 M KF, buffered with 5 mM Tris * HCl to pH 7.4 at 250. The same patch isolation procedure was used for both intact and internally perfused axons.Measurement of the isolation, by application of constantcurrent rectangular pulses to the axon patch through the inner pipette during sucrose flow, gave apparent patch impedances, Zap, (i.e., membrane patch impedance in parallel with the sucrose shunt-path impedance) of 1-6 MU. By raising the current-source level, patch action potentials of 50-80 mV amplitude were recorded between the inner pipette and the chamber ground while the axon was in the flowing sea water and without any electrodes in the axon. These and other tests indicated that the isolation was more than adequate for observing the patch noise without high-level background noise (e.g., thermal noise of access resistances to the patch surfaces). Additional tests showed that the fluctuation wave-876

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“…A well established conceptual and experimental framework exists for the measurement of membrane voltage noise [48][49][50][51], and several groups are presently engaged in the experimental study of membrane noise, and its changes under the action of external fields [52,53]. We plan to establish a research cooperation with these groups, aimed at checking our results against experiments in a future paper.…”

Section: Discussionmentioning

confidence: 99%

Nonlinear Interaction of Electromagnetic Radiation at the Cell Membrane Level: Response to Stochastic Fields

Vita

Croce²,

Pinto³

et al. 2011

PIER B

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Abstract-A general rigorous analytic framework for computing the transmembrane potential shift resulting from the nonlinear voltagecurrent membrane relationship in response to wideband stochastic electromagnetic radiation is outlined, based on Volterra functional series. The special case of an insulated cylindrical cell with HodgkinHuxley membrane in an infinite homogeneous medium is worked out in detail, for the simplest case where the applied electric is normal to the cell axis, and independent from the axial coordinate. Representative computational results for a zero-average stationary band-limited white Gaussian incident field are illustrated and briefly discussed.

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Fluctuations of Resting Neural Membrane Potential

Abstract: The menmbrane potential of myelinated axons in the resting state shows fluctuations for which the power per cycle of bandwidth is inversely proportional to frequency between I and 10,000 radians per second. Reduction of potassiulm ion flux leads to a decrease in noise power.

Cited by 99 publications

References 13 publications

Channel noise in nerve membranes and lipid bilayers

Channel noise in nerve membranes and lipid bilayers

Relaxation Spectra of Potassium Channel Noise from Squid Axon Membranes

Nonlinear Interaction of Electromagnetic Radiation at the Cell Membrane Level: Response to Stochastic Fields

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