Fluid bed film coating of fine ibuprofen particles

Abstract

Fine pharmaceutical powders pose significant challenge in fluid bed (FB) film coating due to their high cohesion. Ibuprofen powders, considered as model Geldart group C powders with Sauter mean diameters of 41 m (coarse) and 22 m (micronized), could not be fluidized due to severe agglomeration, solid-bridging, and poor flowability. Dry coating, applied as a pre-processing method that coats nano-silica on the surface of ibuprofen, enabled sufficiently improved flow, hence fluidization via reduced cohesion. Resulting coarse and micronized ibuprofen powders were successfully polymer film coated in a top spray fluidized bed. As a major novelty, apart from pre-processing through 20 nm silica surface coating that enabled fluidization, agglomeration during FB processing was minimized by introducing 180 nm colloidal silica particles that were pH stabilized in polymer spraying suspension using NaOH. In contrast, lack of or poorly stabilized colloidal particles led to significant agglomeration. Spray rate and fluidization velocity were both investigated to understand their effect on agglomeration of the coarse ibuprofen powders. Increased spray rate led to increased agglomeration due to the overly wet conditions, while increased fluidization velocities unexpectedly led to increased agglomeration resulting from electrostatic charging. To simplify the experimental design, a simple scaling relationship was introduced to estimate the coating conditions for the micronized ibuprofen powders based on the processing conditions of the coarse ibuprofen powders. This relationship, based on the minimum fluidization velocity, led to comparable agglomeration levels for powders with Sauter mean diameters of 21 and 42 m. To the author's knowledge these are the first successful results where micronized pharmaceutical powders were polymer coated in a traditional top spray fluidized bed.

Synthesis of Mesoporous Carbon CMK-3 and CMK-5 Materials and Their Application for Drug Loading-Release System

“…shows the morphology and three dimension image of CMK-3 and CMK-5 observed by SEM. The aggregates of CMK-3 and CMK-5 as can be observed in SEM images show three dimension size of 0.5x3x10 µm 3 and 0.1x2x10 µm3 , respectively.The shape of CMK-3 was observed as a noodle-like structure but CMK-5 appeared as a bunch of noodle-like structure with overlapping parts in the whole surface. The CMK-3 morphology is similar to CMK-5 with small differences in mouth pore and overlapping sites.…”

“…In ibuprofen research of drug delivery model, it was reported that the adsorption method is the most effective technique to remove this organic molecule drug as a pollutant in the aquatic area [3]. The previous report has been used activated carbon as adsorbent not only for ibuprofen but also for another organic pollutant [4].…”

Selection of Small Amounts of Glidant Capable of Improving the Tensile Strength of Ibuprofen Tablets

“…[13][14][15] Surface modification is a method for improving the cohesiveness and flowability of APIs using a small amount of additives. 16) The surface modification method can alleviate problematic properties by coating the surface of API particles with fine-particle excipients or water-soluble polymers. In particular, the dry surface modification method is a simple coating method that involves simply mixing a drug and an excipient; several studies describing such methods have been reported.…”

Novel Technique for Coating of Fine Particles Using Fluidized Bed and Aerosol Atomizer

“…To overcome these issues, conventional methods can be optimized by improving the particles or modifying the fluidized bed. Thereby, powders can be granulated with larger particles in order to enhance the fluidization, drying and coating process in the fluidized bed [13]. Otherwise, fluidization can also be assisted by a variety of mechanisms such as vibration, mechanical agitation, sound and magnetic force to improve the flowability of cohesive particles [6,14,15].…”