Fluid Cartilage as New Autologous Biomaterial in the Treatment of Minor Nose Defects: Clinical and Microscopic Difference Amongst Diced, Crushed, and Fluid Cartilage

Abstract

Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Fourteen patients with minor contour deformity were treated with fluid cartilage filler gently injected as autologous fluid graft in deep planes of defect of the nose that were close to the bone or the cartilage. A computerized tomographic scan control was performed after 12 months. Pearson’s Chi-square test was used to investigate differences in cartilage density between native and newly formed cartilages. The endpoints were the possibility of using fluid cartilage as filler with aesthetic and functional improvement and versatility. Patients were followed up for two years. The constructs of fluid cartilage graft that were injected in the deep plane resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation. This report demonstrated that fluid cartilage grafts are useful for cartilage regeneration in patients with outcomes of rhinoplasty, internal nasal valve collapse, and minor congenital nose aesthetics deformity.

A randomized blinded retrospective study: the combined use of micro-needling technique, low-level laser therapy and autologous non-activated platelet-rich plasma improves hair re-growth in patients with androgenic alopecia

“…Also, the use of HFSCs and Adipose-Derived follicle Stem Cells, as autologous cellular therapy minimally invasive, that promoting the release of GFs involved in HG, had an important role in the regenerative aspects of HG. Recently, on autologous cellular therapy minimally invasive, many investigations have appeared with the aim to promote regenerative medicine in different fields, additionally over of HR-G [47] for example, with the use of human periodontal stem cells in bone regeneration [48][49][50][51][52], in esthetic soft tissue improvement [53], in wound healing [54][55][56], and in reconstructive purposes [57][58][59][60], widening the horizons of regeneration to hitherto unexplored fields. In every case, as previously discussed, without a standardized use of innovative procedures and also cellular therapies with a specific control quality assessment, regenerative therapies would be difficult if not simply unreliable.…”

Ultra Diced Cartilage Graft in Rhinoplasty: A Fine Tool

“…9 The viability of diced cartilage was compared with crushed or morselized cartilage graft in several studies. 16 Diced cartilage has shown superior results with more viable chondrocytes compared with the other two methods of graft preparation. Thus, pieces of cartilage should be diced smaller than 0.2 mm in diameter with sharp blades, and this takes a really long time but is a good investment to prevent complications.…”

Non-surgical Rhinoplasty (NSR): A Systematic Review of Its Techniques, Outcomes, and Patient Satisfaction

“…These limitations include the study being conducted only on Caucasian individuals, which limits the results to this racial group; moreover, it was a single-centre analysis based on a small sample size [ 13 ]. On the other hand, another paper by Trivisonno et al focused on the use of fluid cartilage as a type of nasal filler to fix and repair minor irregularities in the nose dorsum [ 16 ]. However, the disadvantage of this technique is that cartilage may be lost in the dead space of the needle, and there is no estimate of the percentage of cartilage survival, indicating that further procedures may be needed for better result satisfaction.…”