Abstract:The heat transfer enhancement and entropy generation of Al 2 O 3 -water nanofluids laminar convective flow in the microchannels with flow control devices (cylinder, rectangle, protrusion, and v-groove) were investigated in this research. The effects of the geometrical structure of the microchannel, nanofluids concentration ϕ(0%-3%), and Reynolds number Re (50-300) were comparatively studied by means of performance parameters, as well as the limiting streamlines and temperature contours on the modified heated surfaces. The results reveal that the relative Fanning frictional factor f/f 0 of the microchannel with rectangle and protrusion devices are much larger and smaller than others, respectively. As the nanofluids concentration increases, f/f 0 increases accordingly. For the microchannel with rectangle ribs, there is a transition Re for obtaining the largest heat transfer. The relative Nusselt number Nu/Nu 0 of the cases with larger nanofluids concentration are greater. The microchannels with cylinder and v-groove profiles have better heat transfer performance, especially at larger Re cases, while, the microchannel with the protrusion devices is better from an entropy generation minimization perspective. Furthermore, the variation of the relative entropy generation S 1 /S 1 0 are influenced by not only the change of Nu/Nu 0 and f/f 0 , but also the physical parameters of working substances.