Fluid Flow at Branching Junctions

Sochi, Taha

doi:10.1615/interjfluidmechres.v42.i1.50

Cited by 12 publications

(19 citation statements)

References 158 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It remains to be seen how well these properties perform in more complex situations. One such situation is nonplanar branching vessels [44] which require evaluating 3D flows. Another situation is the fluid containing a variety of objects in addition to the robot.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Identifying vessel branching from fluid stresses on microscopic robots

Hogg

2020

Control Systems Design of Bio-Robotics and Bio-Mechatronics With Advanced Applications

View full text Add to dashboard Cite

Objects moving in fluids experience patterns of stress on their surfaces determined by the geometry of nearby boundaries. Flows at low Reynolds number, as occur in microscopic vessels such as capillaries in biological tissues, have relatively simple relations between stresses and nearby vessel geometry. Using these relations, this paper shows how a microscopic robot moving with such flows can use changes in stress on its surface to identify when it encounters vessel branches.

show abstract

Section: Discussionmentioning

confidence: 99%

“…These vessels generally have radii of curvature of tens of microns [37], and when they split, they typically split into just two branches [7]. The branches have a larger total cross section than the main vessel [33], leading to slower flows in the branches [44].…”

Section: The Geometry Of Microscopic Vesselsmentioning

confidence: 99%

Identifying vessel branching from fluid stresses on microscopic robots

Hogg

2020

Control Systems Design of Bio-Robotics and Bio-Mechatronics With Advanced Applications

View full text Add to dashboard Cite

show abstract

“…Under simple shear flow, only two motions, “tumbling” and “tank-treading,” have been described experimentally that relate to cell mechanics of the RBC 20 . Vascular network includes one-to-two branching (bifurcation) and one-to-many branching (trifurcation, quadfurcation and so on) 21 . Therefore, nature of fluidics, flow pattern, and shear have wide range of possibilities in biological vascular network.…”

Section: Discussionmentioning

confidence: 99%

Mechanical perturbations trigger endothelial nitric oxide synthase activity in human red blood cells

Nagarajan¹,

Raj²,

Venkatesan³

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Nitric oxide (NO), a vascular signaling molecule, is primarily produced by endothelial NO synthase. Recently, a functional endothelial NO synthase (eNOS) was described in red blood cells (RBC). The RBC-eNOS contributes to the intravascular NO pool and regulates physiological functions. However the regulatory mechanisms and clinical implications of RBC-eNOS are unknown. The present study investigated regulation and functions of RBC-eNOS under mechanical stimulation. This study shows that mechanical stimuli perturb RBC membrane, which triggers a signaling cascade to activate the eNOS. Extracellular NO level, estimated by the 4-Amino-5-Methylamino-2′, 7′-Difluorofluorescein Diacetate probe, was significantly increased under mechanical stimuli. Immunostaining and western blot studies confirmed that the mechanical stimuli phosphorylate the serine 1177 moiety of RBC-eNOS, and activates the enzyme. The NO produced by activation of RBC-eNOS in vortexed RBCs promoted important endothelial functions such as migration and vascular sprouting. We also show that mechanical perturbation facilitates nitrosylation of RBC proteins via eNOS activation. The results of the study confirm that mechanical perturbations sensitize RBC-eNOS to produce NO, which ultimately defines physiological boundaries of RBC structure and functions. Therefore, we propose that mild physical perturbations before, after, or during storage can improve viability of RBCs in blood banks.

show abstract

“…However, since the pressure field inside a distensible tube and the resulting flow rate are dependent on the actual value of the two boundary conditions and not only on their difference (i.e. pressure drop) [46] we define the yield condition for distensible tubes as the minimum inlet pressure for a given outlet pressure that mobilizes the yield-stress material and initiates a measurable flow. The generally accepted condition for the yield of a yield-stress material in a tube is given by equating the magnitude of the wall shear stress |τ | to the yield-stress of the fluid τ where τ is defined as the ratio of the force normal to the tube axis F ⊥ to the area of the luminal surface parallel to this force A || .…”

Section: Yield Conditionmentioning

confidence: 99%

The yield condition in the mobilization of yield-stress materials in distensible tubes

Sochi

2014

Open Physics

Self Cite

View full text Add to dashboard Cite

Abstract:In this paper we investigate the yield condition in the mobilization of yield-stress materials in distensible tubes. We discuss the two possibilities for modeling the yield-stress materials prior to yield: solid-like materials and highly-viscous fluids and identify the logical consequences of these two approaches on the yield condition. Our results reveal that these two modeling approaches have far reaching consequences on the yield bottleneck and hence should be critically examined in the light of experimental evidence. As part of this investigation we derive an analytical expression for the pressure field inside a distensible tube with a Newtonian flow using a one-dimensional Navier-Stokes flow model in conjunction with a pressurearea constitutive relation based on elastic tube wall characteristics. This analytical expression has wider applicability than in the identification of the yield condition of yield-stress material.

show abstract

Fluid Flow at Branching Junctions

Cited by 12 publications

References 158 publications

Identifying vessel branching from fluid stresses on microscopic robots

Identifying vessel branching from fluid stresses on microscopic robots

Mechanical perturbations trigger endothelial nitric oxide synthase activity in human red blood cells

The yield condition in the mobilization of yield-stress materials in distensible tubes

Contact Info

Product

Resources

About