Fluid Intake and Vasopressin: Connecting the Dots

Guelinckx, Isabelle; Vecchio, Mariacristina; Perrier, Erica T.; Lemetais, Guillaume

doi:10.1159/000446198

Cited by 22 publications

(32 citation statements)

References 29 publications

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“…The impact of low daily water intake on long term health has, in the past, attracted little attention [10]. A recent study revealed, however, that plasma vasopressin (ADH) levels were significantly enhanced in low drinkers (≤ 1.2 litres/d of total fluid intake, i.e.…”

Section: Impact Of Drinking Behaviour On the Vasopressin-cortisol-sgkmentioning

confidence: 99%

Two Liters a Day Keep the Doctor Away? Considerations on the Pathophysiology of Suboptimal Fluid Intake in the Common Population

Läng

Guelinckx

Lemetais

et al. 2017

Kidney Blood Press Res

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Suboptimal fluid intake may require enhanced release of antidiuretic hormone (ADH) or vasopressin for the maintenance of adequate hydration. Enhanced copeptin levels (reflecting enhanced vasopressin levels) in 25% of the common population are associated with enhanced risk of metabolic syndrome with abdominal obesity, type 2 diabetes, hypertension, coronary artery disease, heart failure, vascular dementia, cognitive impairment, microalbuminuria, chronic kidney disease, inflammatory bowel disease, cancer, and premature mortality. Vasopressin stimulates the release of glucocorticoids which in turn up-regulate the serum- and glucocorticoid-inducible kinase 1 (SGK1). Moreover, dehydration upregulates the transcription factor NFAT5, which in turn stimulates SGK1 expression. SGK1 is activated by insulin, growth factors and oxidative stress via phosphatidylinositide-3-kinase, 3-phosphoinositide-dependent kinase PDK1 and mTOR. SGK1 is a powerful stimulator of Na⁺/K⁺-ATPase, carriers (e.g. the Na⁺,K⁺,2Cl^- cotransporter NKCC, the NaCl cotransporter NCC, the Na⁺/H⁺ exchanger NHE3, and the Na⁺ coupled glucose transporter SGLT1), and ion channels (e.g. the epithelial Na⁺ channel ENaC, the Ca²⁺ release activated Ca²⁺ channel Orai1 with its stimulator STIM1, and diverse K⁺ channels). SGK1 further participates in the regulation of the transcription factors nuclear factor kappa-B NFκB, p53, cAMP responsive element binding protein (CREB), activator protein-1, and forkhead transcription factor FKHR-L1 (FOXO3a). Enhanced SGK1 activity fosters the development of hypertension, obesity, diabetes, thrombosis, stroke, inflammation including inflammatory bowel disease and autoimmune disease, cardiac fibrosis, proteinuria, renal failure as well as tumor growth. The present brief review makes the case that suboptimal fluid intake in the common population may enhance vasopressin and glucocorticoid levels thus up-regulating SGK1 expression and favouring the development of SGK1 related pathologies.

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Section: Impact Of Drinking Behaviour On the Vasopressin-cortisol-sgkmentioning

confidence: 99%

Two Liters a Day Keep the Doctor Away? Considerations on the Pathophysiology of Suboptimal Fluid Intake in the Common Population

Läng

Guelinckx

Lemetais

et al. 2017

Kidney Blood Press Res

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“…Plasma concentration of AVP has been classically used in the diagnostic process of all these disorders, but its structural instability, its very short plasma half-life and, last but not least, the long-lasting laboratory processing have limited its use in clinical practice [6,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Distribution of plasma copeptin levels and influence of obesity in children and adolescents

et al. 2020

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In recent years, a more stable AVP surrogate, called copeptin, has been used as an adjuvant diagnostic tool for dysnatremia in adults and appears to be promising even in the pediatric age. The aim of this study is to present the distribution of plasma copeptin in a large pediatric cohort and to observe the influence of fluid consumption and obesity on its values. A cohort of 128 children and adolescents was divided into two groups on the basis of nocturnal deprivation (group A) or free access to oral fluids in the 6-8 h before blood collection (group B). At all distribution percentiles, copeptin levels were higher (p < 0.0001) in group A, as were plasma sodium levels and osmolality (p = 0.02 and p = 0.008, respectively). The influence of BMI on copeptin levels was investigated by dividing the cohort into nonobese (group C) and obese children and adolescents (group D). Copeptin levels were higher in group D (p = 0.04). Conclusion: The measurement of copeptin could represent a useful tool for the diagnostic pathway of dysnatremic conditions, but its interpretation should take into consideration the state of hydration. Furthermore, it could also be a promising marker for obesity and metabolic syndrome, although this hypothesis needs further studies to be confirmed.

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“…Low fluid intake, or its biomarkers, has been associated with an increased risk of developing cardiometabolic diseases [ 1 , 2 ], chronic kidney disease [ 3 ] and recurrent kidney stones [ 4 ]. Adequate hydration has been shown to improve cognition in children [ 5 ] and adults [ 6 ], improve mood [ 7 , 8 ] and attenuate biological risk factors for the above-mentioned conditions.…”

Section: Introductionmentioning

confidence: 99%

Fluid intake patterns of children and adolescents: results of six Liq.In7 national cross-sectional surveys

et al. 2018

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PurposeThis study aimed to identify and characterize patterns of fluid intake in children and adolescents from six countries: Argentina, Brazil, China, Indonesia, Mexico and Uruguay.MethodsData on fluid intake volume and type amongst children (4–9 years; N = 1400) and adolescents (10–17 years; N = 1781) were collected using the validated 7-day fluid-specific record (Liq.In7 record). To identify relatively distinct clusters of subjects based on eight fluid types (water, milk and its derivatives, hot beverages, sugar-sweetened beverages (SSB), 100% fruit juices, artificial/non-nutritive sweetened beverages, alcoholic beverages, other beverages), a cluster analysis (partitioning around k-medoids algorithm) was used. Clusters were then characterized according to their socio-demographics and lifestyle indicators.ResultsThe six interpretable clusters identified were: low drinkers–SSB (n 523), low drinkers–water and milk (n 615), medium mixed drinkers (n 914), high drinkers–SSB (n 513), high drinkers–water (n 352) and very high drinkers–water (n 264). Country of residence was the dominant characteristic, followed by socioeconomic level, in all six patterns.ConclusionsThis analysis showed that consumption of water and SSB were the primary drivers of the clusters. In addition to country, socio-demographic and lifestyle factors played a role in determining the characteristics of each cluster. This information highlights the need to target interventions in particular populations aimed at changing fluid intake behavior and improving health in children and adolescents.Electronic supplementary materialThe online version of this article (10.1007/s00394-018-1725-y) contains supplementary material, which is available to authorized users.

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Fluid Intake and Vasopressin: Connecting the Dots

Cited by 22 publications

References 29 publications

Two Liters a Day Keep the Doctor Away? Considerations on the Pathophysiology of Suboptimal Fluid Intake in the Common Population

Two Liters a Day Keep the Doctor Away? Considerations on the Pathophysiology of Suboptimal Fluid Intake in the Common Population

Distribution of plasma copeptin levels and influence of obesity in children and adolescents

Fluid intake patterns of children and adolescents: results of six Liq.In7 national cross-sectional surveys

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