Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage

García-Arroyo, Fernando E.; Tapia, Edilia; Muñoz-Jiménez, Itzel; Gonzaga-Sánchez, Guillermo; Arellano‐Buendía, Abraham S.; Osorio‐Alonso, Horacio; Manterola-Romero, Lino; Roncal-Jiménez, Carlos A.; Johnson, Richard J.; Sánchez‐Lozada, Laura G.

doi:10.1155/2020/8850266

Cited by 5 publications

(5 citation statements)

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“…Underhydration due to low water intake or recurrent mild dehydration is associated with the chronic activation of the renin angiotensin system, endothelin, vasopressin, and the aldose reductase-fructokinase (AR-F) pathway [ 59 , 60 ]. While the renin-angiotensin and endothelin systems have been better characterized in acute hypohydration [ 61 ], the present review will focus on the role of the vasopressin and AR-F pathways, as well as their interactions and synergistic effects.…”

Section: Metabolic Cardiovascular and Renal Effects Resulting From Po...mentioning

confidence: 99%

Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases

et al. 2022

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Improper hydration habits are commonly disregarded as a risk factor for the development of chronic diseases. Consuming an intake of water below recommendations (underhydration) in addition to the substitution of sugar-sweetened beverages (SSB) for water are habits deeply ingrained in several countries. This behavior is due to voluntary and involuntary dehydration; and because young children are exposed to SSB, the preference for a sweet taste is profoundly implanted in the brain. Underhydration and SSB intake lead to mild hyperosmolarity, which stimulates biologic processes, such as the stimulation of vasopressin and the polyol-fructose pathway, which restore osmolarity to normal but at the expense of the continued activation of these biological systems. Unfortunately, chronic activation of the vasopressin and polyol-fructose pathways has been shown to mediate many diseases, such as obesity, diabetes, metabolic syndrome, chronic kidney disease, and cardiovascular disease. It is therefore urgent that we encourage educational and promotional campaigns that promote the evaluation of personal hydration status, a greater intake of potable water, and a reduction or complete halting of the drinking of SSB.

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Section: Metabolic Cardiovascular and Renal Effects Resulting From Po...mentioning

confidence: 99%

Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases

et al. 2022

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“…The increased intake of high-calorie beverages leads to many health problems, such as obesity, diabetes and metabolic syndrome or post-exercise airway narrowing ( Cao et al, 2016 ; Emerson et al, 2016 ). The high consumption of sugars, together with a low intake of water, leads to chronic kidney problems ( Garcia-Arroyo et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…The adverse impact of physical exercise on the kidneys is less known and less explored ( Hoffman and Weiss, 2016 ). Renal damage following physical exertion is relatively rare, and is most often the consequence of severe hypohydration, muscle damage or rapid weight loss ( Sawka et al, 2007 ; Garcia-Arroyo et al, 2020 ; Juett et al, 2020 ; Krisher et al, 2020 ; Juett et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…A high intake of beverages containing sugar leads to metabolic diseases such as obesity, diabetes and hyperuricemia, cardiological, and nephrological complications, hypertension and cancers. ( Johnson et al, 2010 ; Singh et al, 2015 ; Bratoeva et al, 2017 ; Johnson et al, 2018 ; Garcia-Arroyo et al, 2020 ; Zafar, et al, 2021 ). In order to reduce the incidence of cardio-metabolic diseases, the WHO suggests controlling body weight by limiting calorie intake and a frequent strategy for this is to reduce the consumption of drinks containing free sugars and replacing sugars in the diet with low or non-caloric substitutes called alternative sweeteners ( Popkin and Hawkes, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

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Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise

et al. 2022

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The proper fluid and carbohydrates intake is essential before and during physical exercise, and for this reason most athletes drink beverages containing a high amount of free sugars. Sweetened soft drinks are also commonly consumed by those not doing any sport, and this habit seems to be both unhealthy and also the cause of metabolic problems. Recently, several sweeteners have been proposed to replace sugars in popular beverages. To examine the impact of free sugars and the popular sweetener xylitol on metabolic profile and the markers of kidney function and injury after exercise the present study was conducted with semi-professional football players. All participants were healthy, with a mean age of 21.91 years. Their sports skills were on the level of the 4th-5th division of the league. The subjects took part in four football training sessions. During each session they drank a 7% solution of sugar (sucrose, fructose, glucose) or xylitol. The tolerability of these beverages and well-being during exercise was monitored. Before and after each training session, blood and urine were collected. The markers of kidney function and injury, uric acid, electrolytes, complete blood count, CRP, serum albumin, serum glucose and the lipid profile were analyzed. The main finding of this study was that the xylitol beverage is the least tolerated during exercise and 38.89% of participants experienced diarrhea after training and xylitol intake. Xylitol also led to unfavorable metabolic changes and a large increase in uric acid and creatinine levels. A mean increase of 1.8 mg/dl in the uric acid level was observed after xylitol intake. Increases in acute kidney injury markers were observed after all experiments, but changes in urine albumin and cystatin C were highest after xylitol. The other three beverages (containing “free sugars” - glucose, fructose and sucrose) had a similar impact on the variables studied, although the glucose solution seems to have some advantages over other beverages. The conclusion is that sweeteners are not a good alternative to sugars, especially during exercise. Pure water without sweeteners should be drunk by those who need to limit their calorie consumption.Clinical Trial Registration:ClinicalTrials.gov, (NCT04310514)

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“…These changes were accompanied by overexpression of V 1 a and V 2 renal receptors, the polyol fructokinase pathway, and increased renal oxidative stress with reduced expression of antioxidant enzymes. Hydration with an unspecified 11% glucose/fructose sweetened beverage significantly amplified those alterations, and it is suggested that current habits of re-hydration with sweetened beverages could be a risk factor in developing kidney damage ( 68 ).…”

Section: Arginine Vasopressin Fructose and Renal Insufficiencymentioning

confidence: 99%

THIRSTY FOR FRUCTOSE: Arginine Vasopressin, Fructose, and the Pathogenesis of Metabolic and Renal Disease

Student

Sowers

Lockette

2022

Front. Cardiovasc. Med.

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We review the pathways by which arginine vasopressin (AVP) and hydration influence the sequelae of the metabolic syndrome induced by high fructose consumption. AVP and inadequate hydration have been shown to worsen the severity of two phenotypes associated with metabolic syndrome induced by high fructose intake–enhanced lipogenesis and insulin resistance. These findings have implications for those who frequently consume sweeteners such as high fructose corn syrup (HFCS). Patients with metabolic syndrome are at higher risk for microalbuminuria and/or chronic kidney disease; however, it is difficult to discriminate the detrimental renal effects of the metabolic syndrome from those of hypertension, impaired glucose metabolism, and obesity. It is not surprising the prevalence of chronic renal insufficiency is growing hand in hand with obesity, insulin resistance, and metabolic syndrome in those who consume large amounts of fructose. Higher AVP levels and low hydration status worsen the renal insufficiency found in patients with metabolic syndrome. This inter-relationship has public health consequences, especially among underserved populations who perform physical labor in environments that place them at risk for dehydration. MesoAmerican endemic nephropathy is a type of chronic kidney disease highly prevalent in hot ambient climates from southwest Mexico through Latin America. There is growing evidence that this public health crisis is being spurred by greater fructose consumption in the face of dehydration and increased dehydration-dependent vasopressin secretion. Work is needed at unraveling the mechanism(s) by which fructose consumption and increased AVP levels can worsen the renal disease associated with components of the metabolic syndrome.

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Fluid Intake Restriction Concomitant to Sweetened Beverages Hydration Induce Kidney Damage

Cited by 5 publications

References 32 publications

Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases

Current Hydration Habits: The Disregarded Factor for the Development of Renal and Cardiometabolic Diseases

Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise

THIRSTY FOR FRUCTOSE: Arginine Vasopressin, Fructose, and the Pathogenesis of Metabolic and Renal Disease

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