“…While interstitial (or poroelastic) suction is often described as a natural consequence of pull-off for biphasic materials, , it implies a sealed interface. Effective sealing is extremely challenging to accomplish due to the ease of fluid flow through gaps between the rough surfaces. , Cartilage is soft, but it is also rough on the scale of 1–10 μm . Thus, the fluid should prefer to flow through the micron-scale gaps between surfaces (paths of least resistance) rather than the nanoscale pores within the tissue. , The resulting interfacial suction force ( F s ) can be modeled as a squeeze film and depends on fluid viscosity (η), contact radius ( a ), retraction rate (δ̇), and mean gap height ( h ).…”