Fluid mechanics and process design of high-pressure antisolvent precipitation of fenofibrate nanoparticles using a customized microsystem

Melzig, Sebastian; Finke, Jan Henrik; Schilde, Carsten; Vierheller, Anke; Dietzel, Andreas; Kwade, Arno

doi:10.1016/j.cej.2019.04.051

Cited by 14 publications

(5 citation statements)

References 33 publications

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“…Among the other microfluidic designs that have been devised over the last decade for LNP production, includes the segmented flow micromixer [64][65][66], high-pressure micromixer [67,68], and a flow-focusing micromixer [69,70]. Recently, Riewe et al studied LNP production (e.g., reproducibility, size and size distribution) via SHM, high-pressure, and a segmented-flow micromixer with different types of lipid carriers (Fig.…”

Section: Synthesis Of Lnps Using Microfluidicsmentioning

confidence: 99%

Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids

Prakash

Shokr

Willemen

et al. 2022

Advanced Drug Delivery Reviews

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Section: Synthesis Of Lnps Using Microfluidicsmentioning

confidence: 99%

Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids

Prakash

Shokr

Willemen

et al. 2022

Advanced Drug Delivery Reviews

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“…Lipid-based nanoparticles were fabricated by mixing 10 mg/mL glycerol monooleate in ethanol with 0.222 mg/mL poloxamer 407 in water (Riewe et al., 2020 ). Results revealed that high-pressure micromixers led to the formation of nanoemulsions and lipid-based nanoparticles with distinctly smaller PS values than that for the corresponding nanoparticles constructed via segmented-flow micromixers (Melzig et al., 2019 ).…”

Section: Different Types Of Nanoparticles Manufactured Using Microflu...mentioning

confidence: 99%

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

et al. 2022

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Microfluidics is used to manipulate fluid flow in micro-channels to fabricate drug delivery vesicles in a uniform tunable size. Thanks to their designs, microfluidic technology provides an alternative and versatile platform over traditional formulation methods of nanoparticles. Understanding the factors that affect the formulation of nanoparticles can guide the proper selection of microfluidic design and the operating parameters aiming at producing nanoparticles with reproducible properties. This review introduces the microfluidic systems’ continuous flow (single-phase) and segmented flow (multiphase) and their different mixing parameters and mechanisms. Furthermore, microfluidic approaches for efficient production of nanoparticles as surface modification, anti-fouling, and post-microfluidic treatment are summarized. The review sheds light on the used microfluidic systems and operation parameters applied to prepare and fine-tune nanoparticles like lipid, poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles as well as cross-linked nanoparticles. The approaches for scale-up production using microfluidics for clinical or industrial use are also highlighted. Furthermore, the use of microfluidics in preparing novel micro/nanofluidic drug delivery systems is presented. In conclusion, the characteristic vital features of microfluidics offer the ability to develop precise and efficient drug delivery nanoparticles.

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“…This can be influenced by several factors, such as the solubility of the drug in melted fat, where the lower concentration of a lipid used will affect the ability to load drug compounds will be smaller. [14][15][16][17][18][19][20] With the P-Value Analysis of variance (ANOVA) on Design Expert 12 software with a 95% confidence level (P-Value > 0.05), 52 0.039 and the data are significant.…”

Section: Adsorption Efficiencymentioning

confidence: 99%

Fenofibrate Characterization of Solid Lipid Nanoparticles Using the High Shear Homogenization Method

Khoiriyah

Perangirangin

Kuncahyo

2022

Nat Sci Eng Tech Jour

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Fenofibrate is a drug that can be used to treat hyperlipidemia where the drug is included in the category of Biopharmaceutical classification system II with poor solubility and high permeability. This causes the need to improve the drug delivery system (DDS) made using the solid lipid nanoparticle (SLN) method. SLN fenofibrate can be made using the high shear homogenization method by determining the formula using Factorial 22 Design Expert 12. The formula is made with a concentration of 0.31-1.25% GMS and 1.25-2% Tween-40, then SLN fenofibrate is made by mixing all ingredients until an emulsion is formed and continued with the SLN critical parameter test. From the test results, the critical parameters of SLN fenofibrate for the particle size of 8 formulas 490; 561; 601; 697; 916; 1040; 1818, and 2410 nm. The results obtained for the polydispersity index, respectively, were 0.02; 0.04; 0.08; 0.30; 0.35; 0.48; 0.51, and 0.65. The zeta potential value of the 8 formulas obtained successive values of 2.8; 3.5; 4.2; 4.8; 5.5; 5.8; 8.1, and 8.8 mV. Calculation of the efficiency of the SLN fenofibrate drug obtained successive values of 77.23; 78.53; 79.51; 80.47; 81.17; 87.38; 87.39, and 87.82%. The SLN method can improve drugs that are included in the Biopharmaceutical classification system class II category with the distribution of test results in the particle size range, and the adsorbed drug is more than 70%.

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Fluid mechanics and process design of high-pressure antisolvent precipitation of fenofibrate nanoparticles using a customized microsystem

Cited by 14 publications

References 33 publications

Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids

Microfluidic fabrication of lipid nanoparticles for the delivery of nucleic acids

Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects

Fenofibrate Characterization of Solid Lipid Nanoparticles Using the High Shear Homogenization Method

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