Numerical studies on stress, deformation, and damages due to fluid flow have been highly carried out using Fluid-Structure Interaction (FSI) in recent years. FSI is highly efficient in investigating a solid domain deformed by the fluid flow. In this study, a one-way fluid-structure interaction study is performed by a straight pipe under different pressure and thermal conditions. Here, the thermophysical properties of the fluid and mechanical properties of the solid domain can be subjected to change during fluid flow. An aluminum straight pipe with a 1 mm wall thickness is operated under 1 Bar, 5 Bar, and 10 Bar with three different surface temperatures -10ºC, 20ºC, and 50ºC. This study aims to investigate the structural variation of aluminum by the temperature and pressure change of operating fluid in the pipe. Variation of thermophysical properties of fluid by heated pipe surface is integrated into the numerical analysis by generated functions. Numerical analysis showed that the variation of temperature in operating fluid highly affects the fluid characteristic and the structural response of the solid domain by different temperatures. An increase in the operating pressure caused maximum deformation to approximately %100 from 1 Bar to 5 Bar, and approximately %120 from 1 Bar to 10 Bar for the adiabatic process as expected but in the heating conditions stress is nearly three times higher than cooling conditions. As a result, one-way FSI solutions are highly effective in investigating the deformed solid domain as a result of flow, thermal, and operating conditions.