Fluid-Structure Interaction Modelling of Left Ventricular Filling

Verdonck, Pascal; Vierendeels, Jan

doi:10.1007/3-540-47789-6_29

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…However, since this approach represents the whole left ventricle (LV) with a single element, it is not possible to reproduce ventricular pressure in particular cases, for example, during the electromechanical desynchronisation of one part of the myocardium, as observed in some patients suffering from heart failure. Other approaches have been proposed in order to represent explicitly, at different levels of detail, cardiac electrical activity (Luo and Rudy 1994;Ten Tusscher et al 2004), excitation-contraction coupling (Wong 1973;Hunter 1995;Rice et al 2000;Kerckhoffs et al 2003a, b), cardiac mechanical activity (Chaudhry and Findley 1996;Nash 1998;Kerckhoffs et al 2003a, b) and mechano-hydraulic coupling (Verdonck 2002;Kerckhoffs et al 2007).…”

Section: Introductionmentioning

confidence: 98%

A Tissue-Level Electromechanical Model of the Left Ventricle: Application to the Analysis of Intraventricular Pressure

et al. 2009

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The ventricular pressure profile is characteristic of the cardiac contraction progress and is useful to evaluate the cardiac performance. In this contribution, a tissue-level electromechanical model of the left ventricle is proposed, to assist the interpretation of left ventricular pressure waveforms. The left ventricle has been modeled as an ellipsoid composed of twelve mechano-hydraulic sub-systems. The asynchronous contraction of these twelve myocardial segments has been represented in order to reproduce a realistic pressure profiles. To take into account the different energy domains involved, the tissue-level scale and to facilitate the building of a modular model, multiple formalisms have been used: Bond Graph formalism for the mechano-hydraulic aspects and cellular automata for the electrical activation. An experimental protocol has been defined to acquire ventricular pressure signals from three pigs, with different afterload conditions. Evolutionary Algorithms have been used to identify the model parameters in order to minimize the error between experimental and simulated ventricular pressure signals. Simulation results show that the model is able to reproduce experimental ventricular pressure. In addition, electro-mechanical activation times have been determined in the identification process. For example, the maximum electrical activation time is reached, respectively, 96.5, 139.3 and 131.5 ms for the first, second, and third pigs. These preliminary results are encouraging for the application of the model on non-invasive data like ECG, arterial pressure or myocardial strain.

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Section: Introductionmentioning

confidence: 98%

A Tissue-Level Electromechanical Model of the Left Ventricle: Application to the Analysis of Intraventricular Pressure

et al. 2009

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“…[1][2][3] Most of approaches proposed descriptions, at many different levels of detail, of the cardiac electrical activity, 4,5 the excitation-contraction coupling, 6,7 the mechanical activity [8][9][10][11] and the mechano-hydraulic coupling. 12 However, translation of these models into clinical practice remains difficult and new methodological approaches are still needed in order to bring these model-based approaches to the clinical field. The global objective of our project is to propose a model-based method for the analysis of 3D regional cardiac motion and deformation, which will be applicable to Cardiac Resynchronization Therapy (CRT) in the pre-and post-operatory phases.…”

Section: Introductionmentioning

confidence: 99%

Validation of a finite element method framework for cardiac mechanics applications

Danan¹,

Rolle²,

Hubert³

et al. 2017

13th International Conference on Medical Information Processing and Analysis

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International audienceModeling cardiac mechanics is a particularly challenging task, mainly because of the poor understanding of the underlying physiology, the lack of observability and the complexity of the mechanical properties of myocardial tissues. The choice of cardiac mechanic solvers, especially, implies several difficulties, notably due to the potential instability arising from the nonlinearities inherent to the large deformation framework. Furthermore, the verification of the obtained simulations is a difficult task because there is no analytic solutions for these kinds of problems. Hence, the objective of this work is to provide a quantitative verification of a cardiac mechanics implementation based on two published benchmark problems. The first problem consists in deforming a bar whereas the second problem concerns the inflation of a truncated ellipsoid-shaped ventricle, both in the steady state case. Simulations were obtained by using the finite element software GETFEM++. Results were compared to the consensus solution published by 11 groups and the proposed solutions were indistinguishable. The validation of the proposed mechanical model implementation is an important step toward the proposition of a global model of cardiac electro-mechanical activity. © 2017 SPIE

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“…However, since this approach represents the whole left ventricle (LV) with a single element, it is not possible to reproduce ventricular pressure in particular cases, for example, during the electro-mechanical desynchronisation of one part of the myocardium, as observed in some patients suffering from heart failure. Other approaches have been proposed in order to represent explicitly, at different levels of detail, cardiac electrical activity (Luo et al 1994;ten Tusscher et al 2004), excitation-contraction coupling (Wong 1973;Hunter 1995;Rice et al 2000;Kerckhoffs et al 2003), cardiac mechanical activity (Chaudhry 1996;Nash 1998;Kerckhoffs et al 2003) and mechanohydraulic coupling (Verdonck 2002;Kerckhoffs et al 2007). …”

Section: Introductionmentioning

confidence: 99%

A tissue-level electromechanical model of the left ventricle: Application to the analysis of intraventricular pressure

Rolle

Hernández

Richard

et al. 2007

2007 Computers in Cardiology

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Abstract:The ventricular pressure profile is characteristic of the cardiac contraction progress and is useful to evaluate the cardiac performance. In this contribution, a tissue-level electromechanical model of the left ventricle is proposed, to assist the interpretation of left ventricular pressure waveforms.The left ventricle has been modeled as an ellipsoid composed of twelve mechano-hydraulic subsystems. The asynchronous contraction of these twelve myocardial segments has been represented in order to reproduce a realistic pressure profiles. To take into account the different energy

show abstract

Fluid-Structure Interaction Modelling of Left Ventricular Filling

Cited by 5 publications

References 14 publications

A Tissue-Level Electromechanical Model of the Left Ventricle: Application to the Analysis of Intraventricular Pressure

A Tissue-Level Electromechanical Model of the Left Ventricle: Application to the Analysis of Intraventricular Pressure

Validation of a finite element method framework for cardiac mechanics applications

A tissue-level electromechanical model of the left ventricle: Application to the analysis of intraventricular pressure

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