Fluid-structure interaction of patient-specific Circle of Willis with aneurysm: Investigation of hemodynamic parameters

Jahed, Mahsa; Ghalichi, Farzan; Farhoudi, Mehdi

doi:10.3233/bme-181732

Cited by 14 publications

(11 citation statements)

References 22 publications

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“…After evaluation of the titles and abstracts, 70 articles were selected for full-text assessment. Three studies met the inclusion criteria for this review [ 26 , 27 , 28 ]. The most frequent reason for exclusion ( n = 30) was that adapted boundary conditions were not personalized.…”

Section: Resultsmentioning

confidence: 99%

“…Jahed et al segmented CoW and IA from CTA images [ 28 ]. Patient-specific pulsatile velocity profiles of inlets and outlets were obtained from Transcranial Doppler (TCD).…”

Section: Resultsmentioning

confidence: 99%

“…Jahed reported that, in the anterior circulation, flow velocity on the contralateral side was higher than on the IA side [ 28 ]. The maximum value of WSS and von-Misses stress was observed in the artery bifurcation and the IA neck.…”

Section: Resultsmentioning

confidence: 99%

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The Role of Hemodynamics through the Circle of Willis in the Development of Intracranial Aneurysm: A Systematic Review of Numerical Models

Shen

Molenberg

Bokkers

et al. 2022

JPM

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Background: The role of regional hemodynamics in the intracranial aneurysmal formation, growth, and rupture has been widely discussed based on numerical models over the past decades. Variation of the circle of Willis (CoW), which results in hemodynamic changes, is associated with the aneurysmal formation and rupture. However, such correlation has not been further clarified yet. The aim of this systematic review is to investigate whether simulated hemodynamic indices of the CoW are relevant to the formation, growth, or rupture of intracranial aneurysm. Methods: We conducted a review of MEDLINE, Web of Science, and EMBASE for studies on the correlation between hemodynamics indices of the CoW derived from numerical models and intracranial aneurysm up to December 2020 in compliance with PRISMA guidelines. Results: Three case reports out of 1046 publications met our inclusion and exclusion criteria, reporting 13 aneurysms in six patients. Eleven aneurysms were unruptured, and the state of the other two aneurysms was unknown. Wall shear stress, oscillatory shear index, von-Mises tension, flow velocity, and flow rate were reported as hemodynamic indices. Due to limited cases and significant heterogeneity between study settings, meta-analysis could not be performed. Conclusion: Numerical models can provide comprehensive information on the cerebral blood flow as well as local flow characteristics in the intracranial aneurysm. Based on only three case reports, no firm conclusion can be drawn regarding the correlation between hemodynamic parameters in the CoW derived from numerical models and aneurysmal formation or rupture. Due to the inherent nature of numerical models, more sensitive analysis and rigorous validations are required to determine its measurement error and thus extend their application into clinical practice for personalized management. Prospero registration number: CRD42021125169.

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Section: Resultsmentioning

confidence: 99%

“…Jahed et al segmented CoW and IA from CTA images [ 28 ]. Patient-specific pulsatile velocity profiles of inlets and outlets were obtained from Transcranial Doppler (TCD).…”

Section: Resultsmentioning

confidence: 99%

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The Role of Hemodynamics through the Circle of Willis in the Development of Intracranial Aneurysm: A Systematic Review of Numerical Models

Shen

Molenberg

Bokkers

et al. 2022

JPM

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“…Recanalization after coiling is related to aneurysmal growth to greater or lesser degrees (3435). Several experimental studies using computational fluid dynamics in a patient-specific vascular model have further indicated that the elasticity of the vascular wall may play a fundamental role in deformation of the arterial wall (363738). A rigid (vs. elastic) wall serves to increase wall shear stress acting on the vascular wall in a pulsatile flow, potentially accentuating the hemodynamic impact on the endothelial cell, intima, and smooth muscle cell.…”

Section: Discussionmentioning

confidence: 99%

De Novo Intracranial Aneurysms Detected on Imaging Follow-Up of Coiled Aneurysms in a Korean Population

et al. 2019

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Objective Coiled aneurysms are known to recanalize over time, making follow-up evaluations mandatory. Although de novo intracranial aneurysms (DNIAs) are occasionally detected during routine patient monitoring, such events have not been thoroughly investigated to date. Herein, we generated estimates of DNIA development during long-term observation of coiled cerebral aneurysms, focusing on incidence and the risk factors involved. Materials and Methods In total, 773 patients undergoing coil embolization of intracranial aneurysms between 2008 and 2010 were reviewed retrospectively. Their medical records and radiologic data accrued over the extended period (mean, 52.7 ± 29.7 months) were analyzed. For the detection of DNIA, follow-up magnetic resonance angiography and/or conventional angiography were used. The incidence of DNIAs and related risk factors were analyzed using Cox proportional hazards regression and Kaplan-Meier product-limit estimator. Results In 19 (2.5%) of the 773 patients with coiled aneurysms, DNIAs (0.56% per patient-year) developed during continued long-term monitoring (3395.3 patient-years). Of these, 9 DNIAs (47.4%) were detected within 60 months, with 10 (52.6%) emerging thereafter. The most common site involved was the posterior communicating artery (n = 6), followed by the middle cerebral artery (n = 5) and the basilar top (n = 4). Multivariate analysis indicated that younger age (< 50 years) (hazard ratio [HR] = 1.045; p = 0.010) and recanalization of coiled aneurysms (HR = 2.560; p = 0.047) were significant factors in DNIA formation, whereas female sex, smoking, and hypertension fell short of statistical significance. Cumulative survival rates without DNIA were significantly higher in older subjects (> 60 years; p < 0.001) and in the absence of post-coiling aneurysm recurrence ( p = 0.006). Conclusion In most patients with coiled aneurysms, development of DNIAs during long-term monitoring is rare. However, younger patients (< 50 years) or patients with recurring aneurysms appear to be predisposed to DNIAs.

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“…The FSI models could simulate the blood flow in CoW [70] and its fluctuations under cervical rotator manipulation [71]. With in-vivo measurement of blood flow velocity by transcranial Doppler as inlet condition, capillary blood pressure as outlet condition, and age-related elastic modulus of arterial wall, Jahed et al investigated the effects of different hemodynamic and mechanical parameters (wall shear stress, blood pressure, mechanical stress, displacement) on the formation of aneurysms [72]. They found strong effects of these parameters on the size of aneurysm and the risk of aneurysm rupture at arterial bifurcations or the neck of aneurysm.…”

Section: Clinical Applicationsmentioning

confidence: 99%

State-of-the-Art Computational Models of Circle of Willis With Physiological Applications: A Review

et al. 2020

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Background: Various computational models of the circle of Willis (CoW) have been developed to non-invasively estimate the blood flow and hemodynamic parameters in intracranial arteries for the assessment of clinical risks such as aneurysms, ischemia, and atherosclerotic plaque growth. This review aims to categorize the latest computational models of CoW and summarize the innovative techniques. Summary of Review: In traditional computational models of CoW, the computational complexity increased from zero-dimensional models to one-dimensional and three-dimensional models. The applications extend from estimating certain hemodynamic parameters to simulating local flow field. The innovative techniques include the combination of models with different dimensions, the extension of vascular structure including heart and veins, as well the addition of distal fractality, cerebral autoregulation, and intracranial pressure. There are some nontraditional models based on fluid-solid-interaction, control theory, and in-vitro experiments. In all kinds of models, the in-vivo data and non-Newtonian rheological models of blood have been widely applied to improve the accuracy of hemodynamic simulation. Conclusion: Firstly, the selection of model depends on its application scenario. The balance between computational complexity and physiological accuracy deserves further investigation. Secondly, the improvement of CoW models relies on the large-scale validations and the combination of various innovative modeling techniques. INDEX TERMS brain modeling, computational modeling, Circle of Willis (CoW), Windkessel effect, pulse wave, computational fluid dynamics (CFD), cerebral blood flow, intracranial arteries.

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Fluid-structure interaction of patient-specific Circle of Willis with aneurysm: Investigation of hemodynamic parameters

Abstract: This study showed that the distribution of parameters was dependent on the geometry of the COW, and maximum values are seen in areas prone to aneurysm formation.

Cited by 14 publications

References 22 publications

The Role of Hemodynamics through the Circle of Willis in the Development of Intracranial Aneurysm: A Systematic Review of Numerical Models

The Role of Hemodynamics through the Circle of Willis in the Development of Intracranial Aneurysm: A Systematic Review of Numerical Models

De Novo Intracranial Aneurysms Detected on Imaging Follow-Up of Coiled Aneurysms in a Korean Population

State-of-the-Art Computational Models of Circle of Willis With Physiological Applications: A Review

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