Flumazenil Decreases the Minimum Alveolar Concentration of Isoflurane in Dogs

Schwartz, Arthur E.; Maneksha, Farrokh R.; Kanchuger, Marc S.; Sidhu, Upinderjit S.; Poppers, Paul J.

doi:10.1097/00000542-198905000-00010

Cited by 14 publications

(7 citation statements)

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“…The MAC of ISO in our dogs following saline injection was 1.2% at 90 minutes and 1.2% at approximately 4.5 hours. Our data are similar to previous studies determining the MAC of ISO in dogs, although on the low end of the range: (Joas & Stephens 1971 [1.48%]; (Steffey & Howland 1977 [1.28 ± 0.06%]; Schwartz et al. 1989 [1.39 ± 0.15, 1.45 ± 0.14 and 1.50 ± 0.35%, in three different groups of dogs]; Steffey et al.…”

Section: Discussionsupporting

confidence: 91%

Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs

Machado¹,

Dyson²,

Maxie

2006

Veterinary Anaesthesia and Analgesia

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Section: Discussionsupporting

confidence: 91%

Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs

Machado¹,

Dyson²,

Maxie

2006

Veterinary Anaesthesia and Analgesia

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“…~t These results are in contrast with those of Schwartz et al who reported a decrease in the MAC of isoflurane by flumazenil in dogs. 12 An antagonizing effect of flumazenil on the action of intravenous anaesthetics may exist, since the GABAreceptor/chloride channel stimulation has been proposed as a possible molecular mechanism of general anaesthesia produced by intravenous anaesthetics. ~3 However, the GABA receptor is a part of a multimolecular membrane complex, which also contains the benzodiazepine receptor, the chloride ionophore, and possibly other molecular entities.…”

Section: Discussionmentioning

confidence: 99%

“…Two minutes later anaesthesia was induced with either thiopentone 7 mg-kg -l or propofol 3 mg. kg -I /v. The patient was placed in the lithotomy position, an oral airway was inserted, and anaesthesia was maintained with CAN J ANAESTH 1993 / 40.: I / pp [10][11][12] Thio -thiopentone, NS -saline, Flum -flumazenil. N20 in 02 via a face mask.…”

Section: Methodsmentioning

confidence: 99%

Flumazenil reduces the duration of thiopentone but not of propofol anaesthesia in humans

1993

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“…Schwieger et al [14] injected flumazenil at doses ranging from 0.5-4.5 mg/kg in dogs anesthetized with enflurane, isoflurane and enflurane/fentanyl, and reported that the injection did not affect the minimal alveolar concentration (MAC) of the inhalation anesthetics or the plasma fentanyl concentration. Moreover, Schwartz et al [15] reported that flumazenil injection in dogs anesthetized with isoflurane anesthesia may play the role of an agonist and not an antagonistin reducing the MAC.…”

Section: Discussionmentioning

confidence: 99%

Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients

Kim

Lee

Kim

et al. 2012

Korean J Anesthesiol

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BackgroundBenzodiazepines have a hypnotic/sedative effect through the inhibitory action of γ-aminobutyric acid type A receptor. Flumazenil antagonizes these effects via competitive inhibition, so it has been used to reverse the effect of benzodiazepines. Recently, flumazenil has been reported to expedite recovery from propofol/remifentanil and sevoflurane/remifentanil anesthesia without benzodiazepines. Endogenous benzodiazepine ligands (endozepines) were isolated in several tissues of individuals who had not received benzodiazepines.MethodsForty-five healthy unpremedicated patients were randomly allocated to either flumazenil or a control groups. Each patient received either a single dose of 0.3 mg of flumazenil (n = 24) or placebo (n = 21). After drug administration, various recovery parameters and bispectral index (BIS) values in the flumazenil and control groups were compared.ResultsMean time to spontaneous respiration, eye opening on verbal command, hand squeezing on verbal command, extubation and time to date of birth recollection were significantly shorter in the flumazenil group than in the control group (P = 0.004, 0.007, 0.005, 0.042, and 0.016, respectively). The BIS value was significantly higher in flumazenil group than in the control group beginning 6 min after flumazenil administration.ConclusionsAdministration of a single dose of 0.3 mg of flumazenil to healthy, unpremedicated patients at the end of sevoflurane/fentanyl anesthesia without benzodiazepines resulted in earlier emergence from anesthesia and an increase in the BIS value. This may indicate that flumazenil could have an antagonistic effect on sevoflurane or an analeptic effect through endozepine-dependent mechanisms.

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Flumazenil Decreases the Minimum Alveolar Concentration of Isoflurane in Dogs

Cited by 14 publications

References 0 publications

Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs

Effects of oxymorphone and hydromorphone on the minimum alveolar concentration of isoflurane in dogs

Flumazenil reduces the duration of thiopentone but not of propofol anaesthesia in humans

Effect of flumazenil on recovery from anesthesia and the bispectral index after sevoflurane/fentanyl general anesthesia in unpremedicated patients

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