Flunarizine in Migraine Prophylaxis: Efficacy and Tolerability of 5 mg and 10 mg Dose Levels

Centonze, Vincenzo; Magrone, D; Vino, M; Caporaletti, P.; Attolini, Ettore; Campanale, G; Albano, O

doi:10.1046/j.1468-2982.1990.1001017.x

Cited by 26 publications

(18 citation statements)

References 23 publications

(14 reference statements)

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“…The positive effect after drug discontinuation of a 6-month treatment seemed to last longer with flunarizine, although both medications significantly reduced migraine frequency and severity [65]. Previous studies found that 10 mg flunarizine may guarantee a more rapid efficacy than 5 mg [66] and it appears to be a very suitable agent for migraine prophylaxis and should be given for more than 2 months in order to obtain full effectiveness [67]. …”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Acupuncture Combined with Tuina Therapy in Patients with Migraine

et al. 2019

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Background: This study aimed to explore the effectiveness of acupuncture combined with tuina therapy in patients with migraine. Methods: A prospective, randomized controlled assessor-blind clinical trial was performed between January 2017 and May 2018, and 135 patients were assigned into acupuncture combined with tuina (A), acupuncture (B), and control (flunarizine hydrochloride) (C) groups, each with 45 patients. Treatments were performed for 12 weeks and a 4-week follow-up. Frequency of attacks, severity of pain, duration of migraine, associated symptoms, patient-reported outcome (PRO) scores, and frequency of analgesic consumption were assessed. Results: The total effective rate was 95.6, 88.9, and 75.6% for group A, B, and C, respectively, with a significant reduction in attack frequency, severity of pain, duration of migraine, and associated symptoms at post-treatment and follow-up compared to pre-treatment. The PRO scores and frequency of analgesic consumption were significantly improved (group A, p < 0.01; groups B and C, p < 0.05). The differences in pre-/post-treatment and in pre-treatment/follow-up in groups A and B were significantly improved compared to group C (A vs. C, p < 0.01; B vs. C, A vs. B, p < 0.05). No significant adverse events occurred. Conclusion: Acupuncture combined with tuina could significantly increase the therapeutic effect of acupuncture in migraine treatment.

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Section: Discussionmentioning

confidence: 99%

The Effectiveness of Acupuncture Combined with Tuina Therapy in Patients with Migraine

et al. 2019

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“…Cinnarizine has a good antimigraine action although few studies have been carried out to investigate its efficacy in migraine [127, 128]. There are insufficient data supporting the efficacy of nimodipine and ciclandelate in migraine [129].…”

Section: Other Drugsmentioning

confidence: 99%

Italian guidelines for primary headaches: 2012 revised version

et al. 2012

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The first edition of the Italian diagnostic and therapeutic guidelines for primary headaches in adults was published in J Headache Pain 2(Suppl. 1):105–190 (2001). Ten years later, the guideline committee of the Italian Society for the Study of Headaches (SISC) decided it was time to update therapeutic guidelines. A literature search was carried out on Medline database, and all articles on primary headache treatments in English, German, French and Italian published from February 2001 to December 2011 were taken into account. Only randomized controlled trials (RCT) and meta-analyses were analysed for each drug. If RCT were lacking, open studies and case series were also examined. According to the previous edition, four levels of recommendation were defined on the basis of levels of evidence, scientific strength of evidence and clinical effectiveness. Recommendations for symptomatic and prophylactic treatment of migraine and cluster headache were therefore revised with respect to previous 2001 guidelines and a section was dedicated to non-pharmacological treatment. This article reports a summary of the revised version published in extenso in an Italian version.

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“…[2][3] The efficacy of Ca ++ antagonists, particularly of flunarizine, in the prophylaxis of migraine is well documented; flunarizine is usually prescribed at a dosage of 5-10 mg per day as a single evening dosage. [4][5][6][7][8][9] It is considered particularly effective in long term therapy 4 and in young subjects. [4][5][6] Both the efficacy and the side effects of flunarizine have been studied comparatively for the 5 and 10 mg dosages, and it has been noted that while the efficacy is similar, the side effects are reduced with the lower dosage.…”

Section: Introductionmentioning

confidence: 99%

Low Dose Flunarizine in the Prophylaxis of Migraine

et al. 1992

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In a period of one year (1990) we selected 40 patients suffering from migraine. For an open randomized study there were 2 groups of patients: the first were treated with 10mg of flunarizine per day and the second with 3 mg per day. The patients were treated for 4 months consecutively. There were 11 drop outs (27.5%): nine for poor compliance and 2 due to side effects. The efficacy of flunarizine in the prophylaxis of migraine was essentially identical in the two dosage groups while the incidence of side effects was considerably reduced in the patients treated with the lower dose.

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Flunarizine in Migraine Prophylaxis: Efficacy and Tolerability of 5 mg and 10 mg Dose Levels

Cited by 26 publications

References 23 publications

The Effectiveness of Acupuncture Combined with Tuina Therapy in Patients with Migraine

The Effectiveness of Acupuncture Combined with Tuina Therapy in Patients with Migraine

Italian guidelines for primary headaches: 2012 revised version

Low Dose Flunarizine in the Prophylaxis of Migraine

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