2006
DOI: 10.2165/00151829-200605030-00007
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Flunisolide Attenuates Nitric Oxide-Induced DNA Damage in Rat Trachea Epithelial Cells

Abstract: In asthma the bronchial epithelium is highly abnormal, with various structural changes. As a consequence, the epithelium becomes an important source of inflammatory mediators that contribute to the ongoing inflammation and remodeling responses occurring in asthma. Compared with normal individuals, the fraction of exhaled nitric oxide (NO) is elevated in patients with asthma, and these levels have been shown to vary with disease activity. Thus, in asthma, epithelial cells may be exposed to large amounts of NO. … Show more

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“…28 In a rat model it has been shown that exhaled nitric oxide, which is elevated in patients with asthma, may cause DNA damage in epithelial cells. 29 A study on persons working outdoors reported a higher prevalence of DNA damage related to air pollution. 30 An inflammatory origin for the recorded DNA changes would also explain why the scores were so high among subjects exposed to asbestos, a condition known to induce a low-level alveolitis.…”
Section: Discussionmentioning
confidence: 99%
“…28 In a rat model it has been shown that exhaled nitric oxide, which is elevated in patients with asthma, may cause DNA damage in epithelial cells. 29 A study on persons working outdoors reported a higher prevalence of DNA damage related to air pollution. 30 An inflammatory origin for the recorded DNA changes would also explain why the scores were so high among subjects exposed to asbestos, a condition known to induce a low-level alveolitis.…”
Section: Discussionmentioning
confidence: 99%