Fluorescein Angiography in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

Arnold, Anthony C.; Hepler, Robert S.

doi:10.1016/s0002-9394(14)73080-6

Cited by 147 publications

(89 citation statements)

References 16 publications

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“…However, changes in this layer may reflect changes in blood flow deeper within the nerve head. 16 Comparisons were made between the unaffected and affected eyes, between the unaffected fellow eyes and the healthy control eyes, and between the affected eyes and the healthy control eyes. The control group consisted of 14 eyes of 7 healthy age-matched volunteers.…”

Section: Methodsmentioning

confidence: 99%

Optic nerve head blood flow measurements in non-arteritic anterior ischaemic optic neuropathy

Leiba

Rachmiel

Harris

et al. 2000

Eye

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Section: Methodsmentioning

confidence: 99%

Optic nerve head blood flow measurements in non-arteritic anterior ischaemic optic neuropathy

Leiba

Rachmiel

Harris

et al. 2000

Eye

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“…The lack of consistent choroidal filling delay in fluorescein angiography studies of NAION suggests that the impaired perfusion arises in the paraoptic tributaries of the SPCA's, distal to their split from the choroidal branches. 23 …”

Section: Pathophysiologymentioning

confidence: 99%

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Miller

Arnold

2014

Eye

191

139

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Nonarteritic anterior ischaemic optic neuropathy (NAION) is the most common acute optic neuropathy in patients over the age of 50 and is the second most common cause of permanent optic nerve-related visual loss in adults after glaucoma. Patients typically present with acute, painless, unilateral loss of vision associated with a variable visual field defect, a relative afferent pupillary defect, a swollen, hyperaemic optic disc, and one or more flame-shaped peripapillary retinal haemorrhages. The pathogenesis of this condition is unknown, but it occurs primarily in patients with structurally small optic discs that have little or no cup and a variety of underlying vascular disorders that may or may not be known at the time of visual loss. There is no consistently beneficial medical or surgical treatment for the condition, but there are now animal models that allow testing of various potential therapies. About 40% of patients experience spontaneous improvement in visual acuity. Patients in whom NAION occurs in one eye have a 15-19% risk of developing a similar event in the opposite eye over the subsequent 5 years.

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“…Diabetic papillopathy was considered one form of nonarteritic anterior ischaemic optic neuropathy, with special characteristics: long duration of disc oedema, mild to-moderate initial visual loss, relatively mild-to- moderate optic nerve dysfunction, and good visual recovery. Unlike nonarteritic ischaemic optic neuropathy, 14 fluorescein angiography in diabetic papillopathy does not show delay in either onset or time to completion of prelaminar optic disk filling. By combining two large series with adult-onset diabetes mellitus (51 eyes of 35 patients 6,7 ), the median duration of papillopathy was 5 months.…”

Section: Discussionmentioning

confidence: 72%

Periocular corticosteroids in diabetic papillopathy

Mansour

El-Dairi

Shehab

et al. 2004

Eye

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Purpose To ascertain the therapeutic effect of periocular corticosteroids in diabetic papillopathy. Methods Prospectively, five consecutive adult-onset diabetic patients with symptomatic diabetic papillopathy underwent visual fields and fluorescein angiography before and after superonasal subtenon injection of corticosteroids. Results The median duration of papillopathy was 2.5 weeks by ophthalmoscopy and 3 weeks by fluorescein angiography. The median recovery time of best-spectaclecorrected visual acuity was 2 weeks. Two patients developed sequential diabetic papillopathy, and both reported faster visual recovery and better subjective vision in treated eyes. In these two patients, the final bestspectacle-corrected visual acuity and visual evoked responses were comparable between the two eyes, while automated visual fields were less constricted in treated eyes. Complications included ocular hypertension, mild progression of cataract, and mild ptosis in one patient each. Conclusions Periocular corticosteroids shortened the duration of diabetic papillopathy from a reported median of 5 months to 3 weeks in the present uncontrolled observational study, partly by their angiostatic and antioedema effects at the level of the anterior optic nerve. Intraocular pressure needs to be monitored in eyes receiving periocular corticosteroids.

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Fluorescein Angiography in Acute Nonarteritic Anterior Ischemic Optic Neuropathy

Cited by 147 publications

References 16 publications

Optic nerve head blood flow measurements in non-arteritic anterior ischaemic optic neuropathy

Optic nerve head blood flow measurements in non-arteritic anterior ischaemic optic neuropathy

Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy

Periocular corticosteroids in diabetic papillopathy

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