Fluorescein-polyethyleneimine coated gadolinium oxide nanoparticles as T1 magnetic resonance imaging (MRI)–cell labeling (CL) dual agents

Xu, Wenlong; Park, Ja Young; Kattel, Krishna; Ahmad, Wasi Uddin; Bony, Badrul Alam; Heo, Woo Choul; Jin, Seong-Uk; Park, Jang Woo; Chang, Yongmin; Kim, Tae Jeong; Park, Ji Ae; Yeon, Ji; Chae, Kwon Seok; Lee, Gang Ho

doi:10.1039/c2ra21052e

Cited by 51 publications

(29 citation statements)

References 45 publications

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“…Magnetic resonance imaging generates exquisite three-dimensional images of tissues and organisms through the measurement of the proton relaxation of water. [5][6][7][8][9][10] It efficiently differentiates normal and unhealthy tissues through the use of exogenous contrast agents, though it provides 10-20 times lower resolution than light microscopy. [11] These techniques have individual unrivalled crystallite sizes obtained from XRD Rietveld analysis; therefore, the particles are monocrystalline.…”

Section: Introductionmentioning

confidence: 99%

Glycine–Nitrate Process for the Elaboration of Eu³⁺‐Doped Gd₂O₃ Bimodal Nanoparticles for Biomedical Applications

et al. 2014

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Monoclinic and cubic europium-doped Gd 2 O 3 structures were selectively synthesized by the glycine-nitrate process by fine control of the synthesis temperature through the crucial fuel/oxidant ratio. The cubic phase is obtained under fuel-rich conditions, whereas stoichiometric conditions induce the simultaneous formation of cubic and monoclinic polymorphs. The samples were subjected to appropriate sintering to obtain highly crystalline and carbon-free materials. The average nanoparticle (NP) size determined by TEM for these nanopowders (23 nm) agrees with the average

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Section: Introductionmentioning

confidence: 99%

Glycine–Nitrate Process for the Elaboration of Eu³⁺‐Doped Gd₂O₃ Bimodal Nanoparticles for Biomedical Applications

et al. 2014

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“…In the case of the PEI-coated nanoparticles, the characteristic IR bands of N-H stretching at 3280 -3310 cm −1 , C-H stretching at 2910 -2950 cm −1 , N-H bending at 1620 -1660 cm −1 , and C-N stretching at 1200 -1100 cm −1 indicated the presence of the corresponding PEI ligand on the nanoparticles. 33 Here, the N-H stretching and bending peaks overlapped with the water stretching and bending peaks, respectively. The ligand is bonded to the nanoparticles through its functional group, namely, COOH, NH 2 , or NH.…”

Section: B Ligand Surface-coating Resultsmentioning

confidence: 99%

Ligand-size and ligand-chain hydrophilicity effects on the relaxometric properties of ultrasmall Gd2O3 nanoparticles

Tegafaw

Lee³

et al. 2016

AIP Advances

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The relaxometric properties of ultrasmall Gd2O3 nanoparticles coated with various ligands were investigated. These ligands include small diacids with hydrophobic chains, namely, succinic acid (Mw = 118.09 amu), glutaric acid (Mw = 132.12 amu), and terephthalic acid (Mw = 166.13 amu), and large polyethylenimines (PEIs) with hydrophilic chains, namely, PEI-1300 (M¯n=1300) and PEI-10000 (M¯n=10000). Ligand-size and ligand-chain hydrophilicity effects were observed. The longitudinal (r1) and transverse (r2) water proton relaxivities generally decreased with increasing ligand-size (the ligand-size effect). The ligand-size effect was weaker for PEI because its hydrophilic chains allow water molecules to access the nanoparticle (the ligand-chain hydrophilicity effect). This result was explained on the basis of the magnetic dipole interaction between the dipoles of the nanoparticle and water proton. In addition, all samples were found to be non-toxic in cellular cytotoxicity tests.

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“…1) was adapted from a method previously described [28], where fluorescein was attached onto gadolinium oxide NPs capped with PEI. In this work the amines of PEI are reacted with the NHS of activated folic acid.…”

Section: Peg280-s-s-peg280-nhs Resulted In the Formation Of An Nhs Fumentioning

confidence: 99%

Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells

Guo

O’Driscoll

Holmes

et al. 2016

International Journal of Pharmaceutics

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Fluorescein-polyethyleneimine coated gadolinium oxide nanoparticles as T1 magnetic resonance imaging (MRI)–cell labeling (CL) dual agents

Cited by 51 publications

References 45 publications

Glycine–Nitrate Process for the Elaboration of Eu³⁺‐Doped Gd₂O₃ Bimodal Nanoparticles for Biomedical Applications

Glycine–Nitrate Process for the Elaboration of Eu³⁺‐Doped Gd₂O₃ Bimodal Nanoparticles for Biomedical Applications

Ligand-size and ligand-chain hydrophilicity effects on the relaxometric properties of ultrasmall Gd2O3 nanoparticles

Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells

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Fluorescein-polyethyleneimine coated gadolinium oxide nanoparticles as T1 magnetic resonance imaging (MRI)–cell labeling (CL) dual agents

Cited by 51 publications

References 45 publications

Glycine–Nitrate Process for the Elaboration of Eu3+‐Doped Gd2O3 Bimodal Nanoparticles for Biomedical Applications

Glycine–Nitrate Process for the Elaboration of Eu3+‐Doped Gd2O3 Bimodal Nanoparticles for Biomedical Applications

Ligand-size and ligand-chain hydrophilicity effects on the relaxometric properties of ultrasmall Gd2O3 nanoparticles

Bioconjugated gold nanoparticles enhance cellular uptake: A proof of concept study for siRNA delivery in prostate cancer cells

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About

Glycine–Nitrate Process for the Elaboration of Eu³⁺‐Doped Gd₂O₃ Bimodal Nanoparticles for Biomedical Applications

Glycine–Nitrate Process for the Elaboration of Eu³⁺‐Doped Gd₂O₃ Bimodal Nanoparticles for Biomedical Applications