Fluorescein sodium‐guided resection of intracranial lesions in 22 dogs

Nakano, Yukiko; Nakata, Kohei; Shibata, Sanae; Heishima, Yasuhiro; Nishida, Hidetaka; Sakai, Hiroki; Yano, Hirohito; Kamishina, Hiroaki

doi:10.1111/vsu.12763

Cited by 8 publications

(12 citation statements)

References 27 publications

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“…MST of ~6 months have been reported in dogs with gliomas treated surgically in combination with metronomic chemotherapy or immunotherapy (166, 180). Resection of these tumors types is likely to become more common and efficacious with the evolution of brain imaging techniques, intraoperative stereotactic and neuronavigational systems, minimally invasive automated tissue resection devices, and “tumor painting” with fluorophores to assist with intraoperative visualization of tumors (152, 153, 181, 182).…”

Section: Contemporary Treatment Of Pbt In Veterinary Medicinementioning

confidence: 99%

Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors

2019

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In the dog, primary intracranial neoplasia represents ~2–5% of all cancers and is especially common in certain breeds including English and French bulldogs and Boxers. The most common types of primary intracranial cancer in the dog are meningioma, glioma, and choroid plexus tumors, generally occurring in middle aged to older dogs. Much work has recently been done to understand the characteristic imaging and clinicopathologic features of these tumors. The gross and histologic landscape of these tumors in the dog compare favorably to their human counterparts with many similarities noted in histologic patterns, subtype, and grades. Data informing the underlying molecular abnormalities in the canine tumors have only begun to be unraveled, but reveal similar pathways are mutated between canine and human primary intracranial neoplasia. This review will provide an overview of the clinicopathologic features of the three most common forms of primary intracranial cancer in the dog, delve into the comparative aspects between the dog and human neoplasms, and provide an introduction to current standard of care while also highlighting novel, experimental treatments that may help bridge the gap between canine and human cancer therapies.

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Section: Contemporary Treatment Of Pbt In Veterinary Medicinementioning

confidence: 99%

Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors

2019

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“…In addition, real-time identification of the blood supply to the tumor, bleeding at the operative site, and bleeding as a result of the biopsy are very beneficial at the time of surgery. Some other methods of intracranial surgery imaging include frame-based stereotactic biopsy (7), intraoperative MRI (8), intraoperative biological staining (9), and the intraoperative navigation systems (10). Each of these are unique with certain advantages and disadvantages.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Ultrasound Applications in Intracranial Surgery

et al. 2021

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The methods and use of intraoperative ultrasound in 33 canine and five feline patients and its ability to localize and identify anatomical structures and pathological lesions in canines and felines undergoing intracranial surgery are described from a case series. All were client-owned referral patients admitted for neurologic evaluation, with an advanced imaging diagnosis of an intracranial lesion, and underwent surgical biopsy or surgical removal of the lesion. Medical records, retrieval and review of imaging reports, and characterization of findings for all canine and feline patients show that intraoperative ultrasound guidance was used in intracranial procedures during the period of 2012 and 2019. Twenty-nine of the canine patients had intracranial tumors. The remainder had various other conditions requiring intracranial intervention. Three of the feline patients had meningiomas, one had a depressed skull fracture, and one had an epidural hematoma. The tumors appeared hyperechoic on intraoperative ultrasound with the exception of cystic portions of the masses and correlated with the size and location seen on advanced imaging. Statistical comparison of the size of images seen on ultrasound and on MRI for 20 of the canine tumors revealed no statistical differences. Neuroanatomical structures, including vascular components, were easily identified, and tumor images correlated well with preoperative advanced imaging. The authors conclude that intraoperative ultrasound is a valuable asset in intracranial mass removals and can augment surgical guidance in a variety of intracranial disorders that require surgery. This is the first known publication in veterinary surgery of using intraoperative ultrasound as a tool in the operating theater to identify, localize, and monitor the removal/biopsy of intracranial lesions in small animals undergoing craniotomy/craniectomy.

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“…The mass, at the time of necropsy, had an estimated volume of 36 cm 3 , which is nine times the median astrocytoma volume of 4.2 cm 3 and over twice the size of the largest feline astrocytoma (15.6 cm 3 ) reported by Troxel et al 3 Use of an intraoperative surgical microscope, endoscopy, MRI, cellular labeling for fluorescence-guided resection and postoperative radiation therapy may improve margins and survival, but there is insufficient evidence to say so definitively. [23][24][25][26] The lack of a broad-based meningeal attachment, contour of the parenchyma around the margins of the mass, degree of peritumoral edema and the heterogeneity of the mass on MRI are not consistent with the typical imaging characteristics of a meningioma and argue for inclusion of other differentials, including glial tumors. 27,28 However, the ovoid shape and strong contrast enhancement, along with the location and apparent meningeal contact, are consistent with the reported appearance of feline meningiomas on MRI.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnosis and clinical outcome following surgical resection of an intracranial grade III anaplastic gemistocytic astrocytoma in a cat

Murthy

Liepnieks

Roy

et al. 2020

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 10-year-old Maine Coon cat was presented for acute onset seizures and cerebrothalamic signs. An intracranial mass, suspected to be a meningioma, was diagnosed on MRI and surgically excised. Histopathology appeared consistent with an atypical meningioma. However, following rapid regrowth of the neoplasm, the patient was humanely euthanized 3 months later. On post-mortem histopathology, the neoplasm was diagnosed as a grade III anaplastic gemistocytic astrocytoma. Relevance and novel information Gemistocytic astrocytomas are rare brain tumors in the feline patient. This case represents the first report of a feline grade III anaplastic gemistocytic astrocytoma in the cerebrum of a cat with surgical excision and recurrence. The challenging nature of ante-mortem diagnosis and the guarded prognosis, despite surgical intervention, are presented in this report.

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Fluorescein sodium‐guided resection of intracranial lesions in 22 dogs

Abstract: The intraoperative use of FS may improve the prognosis of dogs with brain tumors by guiding the resection of lesions.

Cited by 8 publications

References 27 publications

Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors

Canine Primary Intracranial Cancer: A Clinicopathologic and Comparative Review of Glioma, Meningioma, and Choroid Plexus Tumors

Intraoperative Ultrasound Applications in Intracranial Surgery

Diagnosis and clinical outcome following surgical resection of an intracranial grade III anaplastic gemistocytic astrocytoma in a cat

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