Fluorescence detecting glycopeptide antibiotics via a dynamic molecular switch

Zou, Xiaomei; Lin, Yanting; Zhang, Shihui; Deng, Tao; Xu, Ximing; Zhou, Yingchun; Liu, Zhihui; Lu, Weiguo; Hu, Qingzhong; Lin, Chaozhan; Zhu, Chenchen; Liu, Fang

doi:10.1016/j.aca.2024.342309

Analytica Chimica Acta

2024

DOI: 10.1016/j.aca.2024.342309

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Fluorescence detecting glycopeptide antibiotics via a dynamic molecular switch

Xiaomei Zou,

Yanting Lin,

Shihui Zhang

et al.

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Reaction‐Based Fluorescence Assays for the Determination of Food Trimethylamine Oxide

Peng,

Huang,

Wang

et al. 2024

Luminescence

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Trimethylamine oxide (TMAO), a microbial metabolite commonly found in foods, has been attracting increasing attention as it is associated with the risk of several diseases. Simple and accurate analytical methods are crucial for TMAO study. In the present study, we proposed a chemical reaction‐based fluorescence assay for TMAO detection using synthetic small molecular probes. After systematic screening and optimization, the sensitive and selective quantification of TMAO has been achieved based on a fluorescence probe P6 (3‐iodopropanyl group modified resorufin). Excellent linearity (R2 = 0.997) was found between 6.25 and 50 μM, and the limit of detection (LOD) was 0.20 μM. Using this method, TMAO levels in several marine fishes and shellfishes have been successfully analyzed. The probe‐based assay offers a simple and useful way for TMAO determination. The design is inspired by the unique oxidation reaction between TMAO and halogen, which opens a new perspective in the development of more advanced analytical assays for TMAO in the future.

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Reaction‐Based Fluorescence Assays for the Determination of Food Trimethylamine Oxide

Peng,

Huang,

Wang

et al. 2024

Luminescence

View full text Add to dashboard Cite

show abstract

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Fluorescence detecting glycopeptide antibiotics via a dynamic molecular switch

Cited by 1 publication

References 36 publications

Reaction‐Based Fluorescence Assays for the Determination of Food Trimethylamine Oxide

Reaction‐Based Fluorescence Assays for the Determination of Food Trimethylamine Oxide

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