Fluorescence Detection of Bladder Cancer: A Review

d'Hallewin, Marie Ange; Bezdetnaya, Lina; Guillemin, François

doi:10.1016/s0302-2838(02)00402-5

Cited by 108 publications

(74 citation statements)

References 79 publications

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“…4), which characterizes the processes of transformation of linearly polarized fluorescent radiation into a circular one. As it is well known [21][22][23][24][25][26][27][28][29][30][31], orientationally (ρ)-phase (δ, θ) structure of this matrix depends on physiological (pathological) state of biological tissue. More disordered by directions (    ) birefringent (Δn ≈ const) fibrillar network is typical for malignant states.…”

Section: Analysis and Discussion Of Experimental Resultsmentioning

confidence: 99%

“…In this work, we have limited ourselves by considering the spectral-selective case -luminescence of optically active porphyrins of biological tissue in red (λ f = 0.63…0.65 μm) spectral range [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Excitation of autofluorescence was realized using a blue solid-state laser with the wavelength λ = 0.405 μm that coincides with the porphyrin absorption peak.…”

Section: Brief Theorymentioning

confidence: 99%

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Fluorescent Mueller-matrix polarimetry of biological tissues in differentiation of benign and malignant tumors

Ushenko¹

2015

Semicond. Phys. Quantum Electron. Optoelectron.

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Abstract. The work is aimed at investigation of diagnostic efficiency provided by a new azimuthally stable Mueller-matrix method for analyzing laser fluorescence coordinate distributions characterizing biological tissue histological sections. A new model of generalized optical anisotropy of biological tissues containing protein networks has been proposed in order to ascertain the processes of laser autofluorescence. The influence of complex mechanisms of both phase anisotropy (linear birefringence and optical activity) and linear (circular) dichroism was taken into account. The interrelations between the azimuthally stable Mueller-matrix elements characterizing laser autofluorescence and different mechanisms of optical anisotropy have been determined. The statistic analysis of coordinate distributions of these Mueller-matrix rotation invariants has been offered. Thereupon the quantitative criteria (statistic moments of the 1st to 4th orders) of differentiation of histological sections of uterus wall tumor -group 1 (dysplasia) and group 2 (adenocarcinoma) have been estimated.

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Section: Analysis and Discussion Of Experimental Resultsmentioning

confidence: 99%

Section: Brief Theorymentioning

confidence: 99%

Fluorescent Mueller-matrix polarimetry of biological tissues in differentiation of benign and malignant tumors

Ushenko¹

2015

Semicond. Phys. Quantum Electron. Optoelectron.

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“…In this work, we have limited ourselves by consideration of a spectral-selective case -luminescence of optically active porphyrins in biological tissues in red (λ f = 0.63…0.65 μm) region of spectrum [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. The excitation of autofluorescence was realized using a blue solid-state laser with the wavelength λ = 0.405 μm that coincides with the porphyrins maximum absorption.…”

Section: Brief Theorymentioning

confidence: 99%

“…As it is well known [21][22][23][24][25][26][27][28][29][30][31], the orientation(  )-phase(  , ) structure of this matrix depends on physiological (pathological) state of biological tissue.…”

mentioning

confidence: 99%

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Differentiation of Mueller-matrix invariants of biological tissues fibrillar networks with different phase and amplitude anisotropy

Ушенко¹

2017

Semicond. Phys. Quantum Electron. Optoelectron.

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Abstract. The work is aimed at investigation of diagnostic efficiency of a new azimuthally stable Mueller-matrix method for analysis of laser autofluorescence coordinate distributions corresponding to biological tissue histological sections. A new model of generalized optical anisotropy observed in biological tissue protein networks has been proposed to study the processes of laser autofluorescence. The influence of complex mechanisms of both phase anisotropy (linear birefringence and optical activity) and linear (circular) dichroism has been taken into account. The interrelations between the azimuthally stable Mueller-matrix elements characterizing laser autofluorescence and different mechanisms of optical anisotropy have been ascertained. The statistic analysis of coordinate distributions inherent to these Mueller-matrix rotation invariants has been proposed. Thereupon the quantitative criteria (statistic moments of the 1 st to 4 th orders) of differentiation of histological sections of uterus wall tumor -group 1 (dysplasia) and group 2 (adenocarcinoma) have been found.

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Optical redox ratio and endogenous porphyrins in the detection of urinary bladder cancer: A patient biopsy analysis

et al. 2016

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Bladder cancer is among the most common cancers in the UK and conventional detection techniques suffer from low sensitivity, low specificity, or both. Recent attempts to address the disparity have led to progress in the field of autofluorescence as a means to diagnose the disease with high efficiency, however there is still a lot not known about autofluorescence profiles in the disease. The multi‐functional diagnostic system “LAKK‐M” was used to assess autofluorescence profiles of healthy and cancerous bladder tissue to identify novel biomarkers of the disease. Statistically significant differences were observed in the optical redox ratio (a measure of tissue metabolic activity), the amplitude of endogenous porphyrins and the NADH/porphyrin ratio between tissue types. These findings could advance understanding of bladder cancer and aid in the development of new techniques for detection and surveillance.

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Fluorescence Detection of Bladder Cancer: A Review

Cited by 108 publications

References 79 publications

Fluorescent Mueller-matrix polarimetry of biological tissues in differentiation of benign and malignant tumors

Fluorescent Mueller-matrix polarimetry of biological tissues in differentiation of benign and malignant tumors

Differentiation of Mueller-matrix invariants of biological tissues fibrillar networks with different phase and amplitude anisotropy

Optical redox ratio and endogenous porphyrins in the detection of urinary bladder cancer: A patient biopsy analysis

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