2023
DOI: 10.5530/ijper.57.3.103
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Fluorescence Detection of Etoposide Encapsulated Mesoporous Silica Nanoparticles by Environmentally Benign Bioanalytical HPLC Method and its Application to Pharmacokinetic Study

Abstract: Introduction: Etoposide belongs to BCS Class IV suffering from solubility and permeability limitations. Thereby, hindering its bioavailability. Thereby, it is imperative to enhance its bioavailability by suitable formulation to achieve a desired therapeutic effect. Objectives: In present work, ETD was encapsulated into mesoporous silica nanoparticles (MSNs) with the aim of achieving bioavailability enhancement. Further, A simple, efficient, and environmentally benign HPLC method with highly sensitive fluoresce… Show more

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