Fluorescence dye loaded nano-graphene for multimodal imaging guided photothermal therapy

Abstract

Photoacoustic imaging (PA) has emerged as a novel and noninvasive imaging modality owing to its high spatial resolution and high soft tissue contrast. Herein, we loaded a near-infrared (NIR) fluorescence dye (CySCOOH) onto the surface of PEGylated graphene oxide (GO) via π-π stacking to increase the NIR absorbance of GO. The PA imaging proved that PEGylated GO-CysCOOH (GO-PEG-CysCOOH) significantly enhances the PA signal in the tumor site compared with free GO-PEG. We then utilized the strong optical absorbance of GO-PEG-CySCOOH in the NIR region for in vivo photothermal therapy, achieving efficient tumor ablation after intravenous injection of GO-PEG-CySCOOH and low-power laser irradiation on the tumor. Our results indicate that this graphene-based nanocomposite can be developed as a promising contrast agent for PA imaging and a thermal agent for imaging guided photothermal therapy.

Phosphorus and Boron Co‐Doped Carbon Coating of LiNi0.5Mn1.5O4 Cathodes for Advanced Lithium‐ion Batteries

“…According to the previous reports, [18] the chemical state of Mn ions is difficult to define, and it has multiply splitting binding energy of the Mn 2p XPS spectrum. The analysis results show that Mn 3 + in LNMO accelerate electron transport, [19] while Mn 4 + may be reduced to Mn 3 + by carbon during the coating process, especially on the surface of particles. Due to the radius of Mn 3 + (65 pm) is bigger than Mn 4 + (54 pm), the disordered structure of LNMO has a higher lattice parameter.…”

A Systematic Review and Critical Analysis of the Role of Graphene-Based Nanomaterials in Cancer Theranostics

“…All 55 studies report the development of GBNs alone [44,45] or often functionalized with different additives [5,6,7,8,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94] for cancer theranostic applications. Each of these studies presented the assessment of the individual role of GBNs either in therapeutic or diagnostic applications.…”

“…Each of these studies presented the assessment of the individual role of GBNs either in therapeutic or diagnostic applications. Within the complete set of studies, the therapeutic performance was evaluated in cellular [6,49,50,52,53,55,63,68,70,80,81,82,83,84,85,86,89,94], or animal models [46,71,77], or both [5,7,46,47,48,51,56,57,58,59,60,61,62,64,66,69,72,73,74,75,76,78,79,81,87,88,90,91,92,93]. In the case of cellular studies, GBNs were incubated at a defined concentration or in a range of concentrations and some studies involved the application of GBNs solely [46,53,54,55,63,68,71,…”

“…In the case of cellular studies, GBNs were incubated at a defined concentration or in a range of concentrations and some studies involved the application of GBNs solely [46,53,54,55,63,68,71,78,82,91] or conjugated with the exposure to a laser source of a defined potency, wavelength, and time [5,6,7,8,44,45,47,48,49,50,51,52,56,57,58,59,60,61,62,64,65,66,67,69,70,72,73,74,75,76,77,79,80,81,83,84,85,86,87,88,89,90,92,93,94]. With the exception of few studies [45,47,87,94], the laser used is a near infrared light source (NIR) that has a trigger effect ...…”

Cutting‐Edge Nanomaterials for Advanced Multimodal Bioimaging Applications

“…The hyperintegration and simple preparation provided an ideal platform for future theranostic applications. Aside from TMDs, graphene oxide (GO) and their composites played important role in the multimodal bioimaging application . Liu and co‐workers anchored SPIONs on reduced GO nanosheets for photothermal therapy and trimodal FI/PAI/MRI in vivo .…”