Fluorescence enhancement of warfarin induced by interaction with β‐cyclodextrin

Vasquez, Jacob M.; Vu, Andrew; Schultz, Jerome S.; Vullev, Valentine I.

doi:10.1002/btpr.188

Cited by 45 publications

(43 citation statements)

References 37 publications

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“…5). This finding indicated that an increase in the ThT emission The observed emission enhancement phenomenon, induced by the endospore uptake, is consistent with the sensitivity of the photophysical properties of ThT to the viscosity of the environment: i.e., the emission quantum yield of ThT increases with the increase in the medium viscosity (72,74,81,82,88,90). Due to the single carbon-carbon bond between the two ring systems and the single carbon-nitrogen bond between the phenyl ring and the dimethyl amine (Fig.…”

Section: Resultssupporting

confidence: 77%

Amyloid Histology Stain for Rapid Bacterial Endospore Imaging

et al. 2011

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Bacterial endospores are some of the most resilient forms of life known to us, with their persistent survival capability resulting from a complex and effective structural organization. The outer membrane of endospores is surrounded by the densely packed endospore coat and exosporium, containing amyloid or amyloid-like proteins. In fact, it is the impenetrable composition of the endospore coat and the exosporium that makes staining methodologies for endospore detection complex and challenging. Therefore, a plausible strategy for facile and expedient staining would be to target components of the protective surface layers of the endospores. Instead of targeting endogenous markers encapsulated in the spores, here we demonstrated staining of these dormant life entities that targets the amyloid domains, i.e., the very surface components that make the coats of these species impenetrable. Using an amyloid staining dye, thioflavin T (ThT), we examined this strategy.

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Section: Resultssupporting

confidence: 77%

Amyloid Histology Stain for Rapid Bacterial Endospore Imaging

et al. 2011

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“…4b), the ratios between which are concentration dependent. We ascribe the red-shifted peak, the intensity of which increases with an increase in concentration, to aggregates that form at the excited and/ or the ground state [46,[75][76][77][78][79][80]. The trends from this assignment of the fluorescence spectra indicate that the chlorinated hydrocarbons, such as DCM, tend to suppress aggregation (Fig.…”

Section: Photophysical Propertiesmentioning

confidence: 85%

Building blocks for bioinspired electrets: molecular-level approach to materials for energy and electronics

Larsen

Espinoza

Hartman

et al. 2015

Pure and Applied Chemistry

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In biology, an immense diversity of protein structural and functional motifs originates from only 20 common proteinogenic native amino acids arranged in various sequences. Is it possible to attain the same diversity in electronic materials based on organic macromolecules composed of non-native residues with different characteristics? This publication describes the design, preparation and characterization of non-native aromatic β-amino acid residues, i.e. derivatives of anthranilic acid, for polyamides that can efficiently mediate hole transfer. Chemical derivatization with three types of substituents at two positions of the aromatic ring allows for adjusting the energy levels of the frontier orbitals of the anthranilamide residues over a range of about one electronvolt. Most importantly, the anthranilamide residues possess permanent electric dipoles, adding to the electronic properties of the bioinspired conjugates they compose, making them molecular electrets.

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“…A typical instrumental pulse using an IBH TBX-04 detector at a time calibration of 13 ps per channel and a scattering sample of LUDOX 1 was about 600 ps at full width half maximum. To remove the additional excitation pulse Ishiwata and Kamiya (1997), Vasquez et al (2009) from the NanoLed at around 430 nm, a cut-off filter (UG-11) was kept in front of the excitation source. Before every sample measurement, the instrument response function was measured using LUDOX 1 solution (excitation and emission wavelengths 295 and 334 nm respectively).…”

Section: Time-resolvedmentioning

confidence: 99%

Warfarin: an environment‐dependent switchable molecular probe

Nicholls

Karlsson

Rosengren

et al. 2010

J of Molecular Recognition

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The complex nature of the structure of the anticoagulant warfarin is reflected in the diversity of binding modes observed in warfarin-protein recognition systems. A series of theoretical, 1 H-NMR and steady state and time resolved fluorescence spectroscopic studies, have been used to establish correlations between the molecular environment provided by various solvent systems and the relative concentrations of the various members of warfarin's ensemble of isomers. A consequence of these observations is that the judicious choice of solvent system or molecular environment of warfarin allows for manipulation of the position of the equilibrium between isomeric structures such as the hemiacetal and open phenol-keto forms, the latter even possible in a deprotonated form, where in each case unique spectroscopic properties are exhibited by the respective structures. Collectively, warfarin's capacity to adapt its structure as a function of environment in conjunction with the fluorescence behaviours of the various isomers together provide an environment-dependent molecular switch with reporter properties, which allows for the simultaneous detection of warfarin in different states with lifetimes spanning the range < 0.10-5.5 ns. These characteristics are here used to examine warfarin binding domains in a series of materials (solvents, protein, inorganic matrix and synthetic polymer). Moreover, these studies demonstrate the potential for using warfarin, or other switchable analogues thereof, as a tool for studying molecular level characteristics, for example local dielectricity.

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Fluorescence enhancement of warfarin induced by interaction with β‐cyclodextrin

Cited by 45 publications

References 37 publications

Amyloid Histology Stain for Rapid Bacterial Endospore Imaging

Amyloid Histology Stain for Rapid Bacterial Endospore Imaging

Building blocks for bioinspired electrets: molecular-level approach to materials for energy and electronics

Warfarin: an environment‐dependent switchable molecular probe

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