Fluorescence-free bis(dithiolene)nickel dyes for surface-enhanced resonance Raman imaging in the second near-infrared window

Li, Jin; Deng, Banglin; Ye, Jian

doi:10.1016/j.biomaterials.2023.122211

Cited by 8 publications

(1 citation statement)

References 55 publications

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“…In comparison, the development of SERS sensors by designing recognition reactions can be used for indirect detection of low Raman-activity targets (such as ions and small molecules), which can greatly expand the SERS detection range. Recently, the development of SERS sensors with the cell silent region (1800–2800 cm –1 ) is attracting growing attention in bioanalysis because this kind of SERS sensor has high anti-interference capability in the biological matrix due to the weak Raman background signal from cells/tissues. − Currently, the SERS-silent region sensors are mostly used to reduce the interferences during cell imaging; few of them are applied to solving the interferences of optical detection of environmental samples.…”

Section: Introductionmentioning

confidence: 99%

Reducing Interferences from Organic Matter during Optical Environmental Detection using SERS-Silent Region Nanosensors: A Case of Nitrite Detection

Liu,

Zhang,

et al. 2024

ACS EST Eng.

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Optical detection techniques are frequently used in environmental monitoring due to their high sensitivity and stability; however, to decrease the optical interferences from environmental matrix remains challenging. Herein, to decrease the optical interferences from dissolved organic matter (DOM), a surface-enhanced Raman scattering (SERS)-silent region (1800–2800 cm–1) sensor has been studied for the detection of NO2 – (a model pollutant) in the presence of DOM. 4-Ethynylaniline (4-EA) was selected as the sensing molecule. The signal band (2205 cm–1) and the internal standard band of 4-EA (1985 cm–1) in the SERS-silent region are used for the quantitative analysis of NO2 –. Since the SERS-silent region can well avoid the overlapping with the DOM signal, the dual-silent band ratio I2205/I1985 exhibits outstanding anti-interference ability toward different common organic matter. Compared with the traditional UV–vis detection, this method maintains a higher sensitivity (with a detection limit of 10–7 M) and a better accuracy (detection recovery ranges from 89.9 to 109.7%) for NO2 – detection in real samples. Furthermore, this SERS dual-silent region sensor has been successfully employed in an environmental survey of a local river. These findings imply that the SERS-silent nanosensor provides a way to develop accurate optical detection techniques for environmental monitoring.

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Section: Introductionmentioning

confidence: 99%

Reducing Interferences from Organic Matter during Optical Environmental Detection using SERS-Silent Region Nanosensors: A Case of Nitrite Detection

Liu,

Zhang,

et al. 2024

ACS EST Eng.

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NIR‐II Surface‐Enhanced Raman Scattering Nanoprobes in Biomedicine: Current Impact and Future Directions

Deng,

Zhang,

Qiu

et al. 2024

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The field of second near‐infrared (NIR‐II) surface‐enhanced Raman scattering (SERS) nanoprobes has made commendable progress in biomedicine. This article reviews recent advances and future development of NIR‐II SERS nanoprobes. It introduces the fundamental principles of SERS nanoprobes and highlights key advances in the NIR‐II window, including reduced tissue attenuation, deep penetration, maximized allowable exposure, and improved photostability. The discussion of future directions includes the refinement of nanoprobe substrates, emphasizing the tailoring of optical properties of metallic SERS‐active nanoprobes, and exploring non‐metallic alternatives. The intricacies of designing Raman reporters for the NIR‐II resonance and the potential of these reporters to advance the field are also discussed. The integration of artificial intelligence (AI) into nanoprobe design represents a cutting‐edge approach to overcome current challenges. This article also examines the emergence of deep Raman techniques for through‐tissue SERS detection, toward NIR‐II SERS tomography. It acknowledges instrumental advancements like improved charge‐coupled device sensitivity and accelerated imaging speeds. The article concludes by addressing the critical aspects of biosafety, ease of functionalization, compatibility, and the path to clinical translation. With a comprehensive overview of current achievements and future prospects, this review aims to illuminate the path for NIR‐II SERS nanoprobes to innovate diagnostic and therapeutic approaches in biomedicine.

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Ultrasensitive NIR‐II Surface‐Enhanced Resonance Raman Scattering Nanoprobes with Nonlinear Photothermal Effect for Optimized Phototheranostics

Song,

2024

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Surface‐enhanced resonance Raman scattering (SERRS) in the second near‐infrared (NIR‐II) window has great potential for improved phototheranostics, but lacks nonfluorescent, resonant and high‐affinity Raman dyes. Herein, it is designed and synthesize a multi‐sulfur Raman reporter, NF1064, whose maximum absorption of 1064 nm rigidly resonates with NIR‐II excitation laser while possessing absolutely nonfluorescent backgrounds. Ultrafast spectroscopy suggests that the fluorescence quenching mechanism of NF1064 originates from twisted intramolecular charge transfer (TICT) in the excited state. Gold nanorods (AuNRs) decorated with such nonfluorescent NF1064 (AuNR@NF1064) show remarkable SERRS performances, including zero‐fluorescence background, femtomolar‐level sensitivity as well as superb photostability without fluorescence photobleaching. More importantly, AuNR@NF1064 exhibits a nonlinear photothermal effect upon plasmonic fields of AuNRs by amplifying the non‐radiative decay of nonfluorescent NF1064, thus achieving a high photothermal conversion of 68.5% in NIR‐II window with potential for further augmentation. With remarkable SERRS and photothermal properties, the NIR‐II nanoprobes allow for high‐precision intraoperative guided tumor resection within 8 min, and high‐efficient hyperthermia combating of drug‐resistant bacterial infection within living mouse body. This work not only unlocks the potential of nonfluorescent resonant dyes for NIR‐II Raman imaging, but also opens up a new method for boosting photothermal conversion efficiency of nanomaterials.

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Fluorescence-free bis(dithiolene)nickel dyes for surface-enhanced resonance Raman imaging in the second near-infrared window

Cited by 8 publications

References 55 publications

Reducing Interferences from Organic Matter during Optical Environmental Detection using SERS-Silent Region Nanosensors: A Case of Nitrite Detection

Reducing Interferences from Organic Matter during Optical Environmental Detection using SERS-Silent Region Nanosensors: A Case of Nitrite Detection

NIR‐II Surface‐Enhanced Raman Scattering Nanoprobes in Biomedicine: Current Impact and Future Directions

Ultrasensitive NIR‐II Surface‐Enhanced Resonance Raman Scattering Nanoprobes with Nonlinear Photothermal Effect for Optimized Phototheranostics

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