Fluorescence Guided Surgery

Stewart, Hazel L.; Birch, David J. S.

doi:10.1088/2050-6120/ac1dbb

Cited by 58 publications

(46 citation statements)

References 199 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most FGS systems employ multiple cameras with optical filters and beamsplitter to achieve coaligned visible and NIR imaging ( 6, 24 ). A potentially simpler approach for real-time overlay of white light reflectance images with fluorescence images is using a single sensor coupled with a modified 4-channel RGB-IR Bayer filter ( 6, 19, 25 ).…”

Section: Resultsmentioning

confidence: 99%

“…However, incorporating an excitation light source into a wearable battery-powered ergonomic design is challenging. Existing FGS systems, for example, employ large cumbersome and expensive laser diodes that are fixed to a cart ( 6, 17, 24 ) and even if the light source is passed through optical fibers to a surgical headmount, the surgeon remains effectively tethered to the cart. Some preclinical FGS systems separate the surgeon from the excitation source completely – the imaging module is worn by the surgeon but the excitation source is placed on a tripod near the surgical field and separated from any wearable components ( 18, 21 ).…”

Section: Resultsmentioning

confidence: 99%

“…The copyright holder for this preprint (which this version posted July 10, 2022. ; https://doi.org /10.1101/10. /2022 Excitation at 780-800 nm can be achieved by use of broadband sources (halogen lamp or NIR light emitting diode (LED) array) coupled with appropriate optical filters, or with narrowband laser diodes (6,24). However, incorporating an excitation light source into a wearable battery-powered ergonomic design is challenging.…”

Section: Excitation Light Sourcementioning

confidence: 99%

See 2 more Smart Citations

Global health open-source goggles for fluorescence-guided surgery

Shmuylovich

O’Brien

Nwosu

et al. 2022

Preprint

View full text Add to dashboard Cite

Fluorescence-guided surgery (FGS), coupled with novel near infrared (NIR) fluorescent contrast agents, has significant potential to improve health but in current practice is less suitable for low resource settings. Although there are efforts to simplify FGS systems, technical, economic, and logistic challenges have hampered its global adoption. To overcome these impediments, we developed a low-cost, open-source, battery-powered and fully wearable FGS system called the fluorescence imaging augmented reality Raspberry Pi-based goggle system (FAR-Pi). Compared to current technologies that are expensive, bulky, and wall-powered, FAR-Pi has higher spatial resolution, depth of focus and fluorescence sensitivity. The FAR-Pi system has broad appeal by detecting the diverse fluorescence of NIR contrast agents undergoing clinical trials, as demonstrated by the successful identification of tumors in vivo with LS301, a tumor-targeting NIR contrast agent. As an open-source, inexpensive, and modifiable system, FAR-Pi promises to broaden access to FGS, thereby improving health worldwide.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Excitation Light Sourcementioning

confidence: 99%

See 1 more Smart Citation

Global health open-source goggles for fluorescence-guided surgery

Shmuylovich

O’Brien

Nwosu

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition to these already FDA-approved molecular tracers used for fluorescent guided surgery, according to a recent review by Barth et al, a total of 39 contrast agents used for tumor-specific targeting are being studied in over 85 clinical trials in the US alone. Three of these novel probes (BLZ 100, LUM 015, and SGM-101) have reached phase III clinical trials and are expected to be approved by the FDA in a couple of years [ 95 , 96 ]. BLZ 100, used for real-time tumor detection during brain and breast cancer surgeries, consists of a natural chlorotoxin peptide, which targets the protein components of cholesterol-rich lipid rafts from cancer lesions [ 97 ].…”

Section: Pafolacianine In Comparison With Other Similar Agents Used F...mentioning

confidence: 99%

Intraoperative Tumor Detection Using Pafolacianine

Dindere

Tanca

Rusu

et al. 2022

IJMS

View full text Add to dashboard Cite

Cancer is a leading cause of death worldwide, with increasing numbers of new cases each year. For the vast majority of cancer patients, surgery is the most effective procedure for the complete removal of the malignant tissue. However, relapse due to the incomplete resection of the tumor occurs very often, as the surgeon must rely primarily on visual and tactile feedback. Intraoperative near-infrared imaging with pafolacianine is a newly developed technology designed for cancer detection during surgery, which has been proven to show excellent results in terms of safety and efficacy. Therefore, pafolacianine was approved by the U.S. Food and Drug Administration (FDA) on 29 November 2021, as an additional approach that can be used to identify malignant lesions and to ensure the total resection of the tumors in ovarian cancer patients. Currently, various studies have demonstrated the positive effects of pafolacianine’s use in a wide variety of other malignancies, with promising results expected in further research. This review focuses on the applications of the FDA-approved pafolacianine for the accurate intraoperative detection of malignant tissues. The cancer-targeting fluorescent ligands can shift the paradigm of surgical oncology by enabling the visualization of cancer lesions that are difficult to detect by inspection or palpation. The enhanced detection and removal of hard-to-detect cancer tissues during surgery will lead to remarkable outcomes for cancer patients and society, specifically by decreasing the cancer relapse rate, increasing the life expectancy and quality of life, and decreasing future rates of hospitalization, interventions, and costs.

show abstract

“…PSs have a finite fluorescence quantum yield and therefore can be utilized for their fluorescent properties. Some of the clinically approved applications of PSs exploit their fluorescence properties for diagnosis and treatment guidance such as fluorescent-guided surgeries (FGS). − While the use of PSs for guiding fluorescence-based surgical resection is well accepted and clinically approved, the limited fluorescence quantum yield of PSs and the general lack of depth profiling conferred by fluorescence imaging are major limitations which can be overcome through other complementary imaging methodologies. Liposomes provide a platform to incorporate multiple contrast agents and enable multimodal imaging where fluorescence imaging can be complemented by other imaging methodologies such as photoacoustic imaging (PAI), Positron Emission Tomography (PET), Computed Tomography (CT), and Magnetic Resonance Imaging (MRI) (Figure ).…”

Section: Functional Significance Of Photosensitizer-loaded Liposomesmentioning

confidence: 99%

Spotlight on Photoactivatable Liposomes beyond Drug Delivery: An Enabler of Multitargeting of Molecular Pathways

Ahsan

Hasan

2022

Bioconjugate Chem.

View full text Add to dashboard Cite

The potential of photoactivating certain molecules, photosensitizers (PS), resulting in photochemical processes, has long been realized in the form of photodynamic therapy (PDT) for the management of several cancerous and noncancerous pathologies. With an improved understanding of the photoactivation process and its broader implications, efforts are being made to exploit the various facets of photoactivation, PDT, and the associated phenomenon of photodynamic priming in enhancing treatment outcomes, specifically in cancer therapeutics. The parallel emergence of nanomedicine, specifically liposome-based nanoformulations, and the convergence of the two fields of liposome-based drug delivery and PDT have led to the development of unique hybrid systems, which combine the exciting features of liposomes with adequate complementation through the photoactivation process. While initially liposomes carrying photosensitizers (PSs) were developed for enhancing the pharmacokinetics and the general applicability of PSs, more recently, PS-loaded liposomes, apart from their utility in PDT, have found several applications including enhanced targeting of drugs, coloading multiple therapeutic agents to enhance synergistic effects, imaging, priming, triggering drug release, and facilitating the escape of therapeutic agents from the endolysosomal complex. This review discusses the design strategies, potential, and unique attributes of these hybrid systems, with not only photoactivation as an attribute but also the ability to encapsulate multiple agents for imaging, biomodulation, priming, and therapy referred to as photoactivatable multiagent/inhibitor liposomes (PMILS) and their targeted versions�targeted PMILS (TPMILS). While liposomes have formed their own niche in nanotechnology and nanomedicine with several clinically approved formulations, we try to highlight how using PS-loaded liposomes could address some of the limitations and concerns usually associated with liposomes to overcome them and enhance their preclinical and clinical utility in the future.

show abstract

Fluorescence Guided Surgery

Cited by 58 publications

References 199 publications

Global health open-source goggles for fluorescence-guided surgery

Global health open-source goggles for fluorescence-guided surgery

Intraoperative Tumor Detection Using Pafolacianine

Spotlight on Photoactivatable Liposomes beyond Drug Delivery: An Enabler of Multitargeting of Molecular Pathways

Contact Info

Product

Resources

About