Fluorescence imaging guided CpG nanoparticles-loaded IR820-hydrogel for synergistic photothermal immunotherapy

Dong, Xia; Liang, Jie; Yang, Afeng; Qian, Zhiyong; Kong, Deling; Lv, Feng

doi:10.1016/j.biomaterials.2019.04.024

Cited by 112 publications

(77 citation statements)

References 53 publications

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“…Most importantly, due to the enhanced anti-tumor immune response, combined photothermal immunotherapy could effectively eliminate tumors and inhibit tumor metastasis of the mice. Dong et al 175 designed a composite hydrogel that contained CpG self-crosslinked nanoparticles and IR820 to achieve photothermal immunotherapy. IR820-hydrogel can effectively generate heat to eliminate the tumor and produced photothermal-induced tumor antigens.…”

Section: Dovepressmentioning

confidence: 99%

Nanomaterial-Based Tumor Photothermal Immunotherapy

Xu¹,

Liang²

2020

IJN

142

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Section: Dovepressmentioning

confidence: 99%

Nanomaterial-Based Tumor Photothermal Immunotherapy

Xu¹,

Liang²

2020

IJN

142

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“…If IT and PTT are combined into one treatment, IT could perform a more therapeutic efficiency against tumors with the help of the released antigens and immunoadjuvants. 60 Guo et al designed chitosan-coated hollow CuS nanoparticles (HCuSNPs) with oligodeoxynucleotides (ODNs) containing cytosine-guanine (CpG) motifs as the immunoadjuvants. CpG ODNs are efficient immunological modulators.…”

Section: Combination Therapy Of Ptt and Itmentioning

confidence: 99%

Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment

Wang¹,

Wu²,

Shen³

et al. 2020

IJN

165

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Background: Cancer is one of the major causes of death and is difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) and immunotherapy (IT)] are widely used but they have limited therapeutic effects and unavoidable side effects. Recently, the development of novel nanomaterials offers a platform for combinational therapy (meaning a combination of two or more therapeutic agents) which is a promising approach for cancer therapy. Recent studies have demonstrated several types of nanomaterials suitable for photothermal therapy (PTT) based on a near-infrared (NIR) light-responsive system. PTT possesses favorable properties such as being low in cost, and having high temporospatial control with minimal invasiveness. However, short NIR light penetration depth limits its functions. Methods: In this review, due to their promise, we focus on inorganic nanomaterials [such as hollow mesoporous silica nanoparticles (HMSNs), tungsten sulfide quantum dots (WS 2 QDs), and gold nanorods (AuNRs)] combining PTT with CHT, RT or IT in one treatment, aiming to provide a comprehensive understanding of PTT-based combinational cancer therapy. Results: This review found much evidence for the use of inorganic nanoparticles for PTTbased combinational cancer therapy. Conclusion: Under synergistic effects, inorganic nanomaterial-based combinational treatments exhibit enhanced therapeutic effects compared to PTT, CHT, RT, IT or PDT alone and should be further investigated in the cancer field.

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“…Anti-PD-L1 [179,180], anti-PD-1 [181][182][183]; poly (I:C) [184], CpG [185,186], LPS, GM-CSF, and anti-PD-1 [187]; CAR-T [188] Electrotherapy: Electrochemotherapy…”

Section: Modulation Of Immune Cells In the Tme Modulation Of T-effsmentioning

confidence: 99%

Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment

Sun

Hyun

et al. 2020

Acta Pharmacol Sin

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Cancer immunotherapy has received extensive attention due to its ability to activate the innate or adaptive immune systems of patients to combat tumors. Despite a few clinical successes, further endeavors are still needed to tackle unresolved issues, including limited response rates, development of resistance, and immune-related toxicities. Accumulating evidence has pinpointed the tumor microenvironment (TME) as one of the major obstacles in cancer immunotherapy due to its detrimental impacts on tumor-infiltrating immune cells. Nanomedicine has been battling with the TME in the past several decades, and the experience obtained could be exploited to improve current paradigms of immunotherapy. Here, we discuss the metabolic features of the TME and its influence on different types of immune cells. The recent progress in nanoenabled cancer immunotherapy has been summarized with a highlight on the modulation of immune cells, tumor stroma, cytokines and enzymes to reverse the immunosuppressive TME.

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Fluorescence imaging guided CpG nanoparticles-loaded IR820-hydrogel for synergistic photothermal immunotherapy

Cited by 112 publications

References 53 publications

<p>Nanomaterial-Based Tumor Photothermal Immunotherapy</p>

<p>Nanomaterial-Based Tumor Photothermal Immunotherapy</p>

<p>Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment</p>

Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment

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