Fluorescence in situ hybridisation (FISH) in histologically challenging conjunctival melanocytic lesions

Mudhar, Hardeep Singh; Smith, Kath; Talley, Polly; Whitworth, Abigail; Atkey, Neil; Rennie, I G

doi:10.1136/bjophthalmol-2012-302261

Cited by 31 publications

(21 citation statements)

References 11 publications

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“…In equivocal conjunctival melanocytic lesions, FISH has been proven useful for classification, especially in cases with atypical junctional activity and naevoid melanocytic proliferations (Mudhar et al. ).…”

Section: Diagnosismentioning

confidence: 99%

Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

Klemp

Kiilgaard

Heegaard

et al. 2017

Acta Ophthalmologica

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Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare paraneoplastic intraocular disease that causes progressive visual loss in patients driven by an IgG factor associated with an underlying malignancy. Characteristic ocular findings include exudative retinal detachment, rapid cataract formation and uveal melanocytic tumours. The awareness and documentation of BDUMP has increased during the past decade, and the increasing amount of data collected demonstrates the effect of treatment with plasmapheresis and the value of diagnostic tools in BDUMP such as genetic and immunologic investigations. The literature of BDUMP has not been reviewed since 2003, and there is a growing need for an updated review on diagnosis and management of BDUMP. We review the literature and report a case of BDUMP with a white ciliary body tumour, iris rubeosis, increased iris pigmentation and cataract.

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Section: Diagnosismentioning

confidence: 99%

Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

Klemp

Kiilgaard

Heegaard

et al. 2017

Acta Ophthalmologica

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“…Various techniques have also been developed to assist ocular pathologists with histopathologically equivocal melanocytic lesions, such as fluorescent in-situ hybridization (FISH) and pump probe microscopy [56,57]; however, these are beyond the scope of this review.…”

Section: Diagnosismentioning

confidence: 99%

Management of conjunctival malignant melanoma: a review and update

Wong

Nanji

Karp

2014

Expert Review of Ophthalmology

144

149

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Conjunctival malignant melanoma is a pigmented lesion of the ocular surface. It is an uncommon but potentially devastating tumor that may invade the local tissues of the eye, spread systemically through lymphatic drainage and hematogenous spread, and recur in spite of treatment. Despite its severity, the rarity of available cases has limited the evidence for diagnosis and management. This review will provide an overview of the epidemiology, presentation, diagnosis, management, and surveillance of conjunctival melanoma, with an emphasis on recent advances in biological therapies to treat this disease.

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“…In addition, FISH analysis was performed for diagnostic purposes. In fact, in recent papers, the application of fluorescence in situ hybridisation has been demonstrated to be a useful tool for the diagnosis of ambiguous melanocytic neoplasms of the conjunctiva [9,10] as demonstrated in skin lesions [11,12]. Taking into account that the sensitivity of the technique is around 87%, a positive FISH result provides additional support in favor of melanoma, whereas a negative FISH result makes melanoma less likely.…”

Section: Discussionmentioning

confidence: 99%

A juvenile case of conjunctival atypical nevus

Colarossi¹,

Milazzo²,

Paglierani

et al. 2013

Diagn Pathol

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Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2973228795724608Melanocytic nevi are the most common tumors of the conjunctiva, accounting for 28% of all neoplastic lesions. These tumors, despite their benign behavior, share some atypical histological features with nevi found in other anatomic sites like the genital and acral regions, globally designated as nevi with site-related atypia. Moreover, in children and adolescents, rapidly growing conjunctival nevi show sometimes worrisome histological patterns in association with a prominent inflammatory infiltrate that may lead to diagnostic problems. In this paper we describe a juvenile compound nevus characterized by marked melanocytic atypia and severe inflammation, which can be considered a rare case of juvenile conjunctival atypical nevus. The final diagnosis relied on morphological and immunohistochemical characterization of the large epithelioid melanocytic cells, and on the results of FISH analysis.

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Fluorescence in situ hybridisation (FISH) in histologically challenging conjunctival melanocytic lesions

Abstract: FISH is very useful in classifying equivocal conjunctival melanocytic lesions, especially those with atypical junctional activity and naevoid melanocytic proliferations of the conjunctiva.

Cited by 31 publications

References 11 publications

Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

Bilateral diffuse uveal melanocytic proliferation: Case report and literature review

Management of conjunctival malignant melanoma: a review and update

A juvenile case of conjunctival atypical nevus

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