Fluorescence in situ hybridization investigation of cutaneous lesions in acute promyelocytic leukemia

Wrede, Joanna E; Sundram, Uma; Köhler, Sabine; Cherry, Athena M.; Arber, Daniel A.; George, Tracy I.

doi:10.1038/modpathol.3800465

Cited by 12 publications

(9 citation statements)

References 25 publications

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“…It is well recognized that oxidants play a role in several stages of carcinogenesis [ 53 ]. OS is associated with numerous pathological phenomena, including infection, inflammation, ultraviolet- and γ-irradiation, increased mutation frequency [ 79 ] and acute promyelocytic leukemia [ 131 ]. Increased free radical generation, especially superoxide anion in leukemia patients and increased antioxidant defense enzymes, which is an adaptive protective response, are indicative of mild OS [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Dual effect of oxidative stress on leukemia cancer induction and treatment

Udensi

Tchounwou

2014

J Exp Clin Cancer Res

123

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Oxidative stress (OS) has been characterized by an imbalance between the production of reactive oxygen species (ROS) and a biological system’s ability to repair oxidative damage or to neutralize the reactive intermediates including peroxides and free radicals. High ROS production has been associated with significant decrease in antioxidant defense mechanisms leading to protein, lipid and DNA damage and subsequent disruption of cellular functions. In humans, OS has been reported to play a role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease, Huntington’s disease, Lou Gehrig’s disease, multiple sclerosis and Parkinson’s disease, as well as atherosclerosis, autism, cancer, heart failure, and myocardial infarction. Although OS has been linked to the etiology and development of chronic diseases, many chemotherapeutic drugs have been shown to exert their biologic activity through induction of OS in affected cells. This review highlights the controversial role of OS in the development and progression of leukemia cancer and the therapeutic application of increased OS and antioxidant approaches to the treatment of leukemia patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s13046-014-0106-5) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Dual effect of oxidative stress on leukemia cancer induction and treatment

Udensi

Tchounwou

2014

J Exp Clin Cancer Res

123

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“…Table 2 indicates characteristics of ATRA-associated scrotal ulceration, which was searched in PubMed with the keywords “ATRA” and “scrotal ulcer.” A total of 33 cases of scrotal ulcers associated with ATRA were summarized [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Fever was observed in all patients but one [ 26 ].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Distinct Characteristics of Sweet’s Syndrome of the Scrotum Caused by All-trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

Imataki¹,

Yoshida²,

Kaji³

et al. 2021

Case Rep Oncol

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Induction therapy with all-trans retinoic acid (ATRA) is effective for acute promyelocytic leukemia (APL). ATRA induces neutrophil differentiation and its associated side effects. The differentiation syndrome is the most characterized ATRA-induced adverse effect. Sweet’s syndrome, also known as neutrophilic dermatosis, is another form of ATRA-associated disease characterized by neutrophil infiltrating erythema that develops with fever. This is a case of a 34-year-old Japanese man diagnosed with APL. At the onset, the patient did not have skin involvement of APL cells. He was treated with ATRA and induction chemotherapy with idarubicin and cytarabine. Scrotal skin rash occurred at day 14, which developed into scrotal ulceration up to day 28 even after eliminating APL cells in his peripheral blood. Sweet’s syndrome is a pathological diagnosis of scrotal skin ulceration representing neutrophil infiltration. The infiltrating neutrophils showed PML-RARα rearrangement. The patient was diagnosed with ATRA-associated Sweet’s syndrome with skin ulcer. His cutaneous lesion did not respond to intravenous prednisolone therapy; thereby, ATRA was discontinued. After the cessation of ATRA, the skin lesion improved in the next week. We confirmed he achieved a complete response after induction chemotherapy. In our observation, ATRA-associated Sweet’s syndrome is characterized by the following clinical manifestations: preferable occurrence in the scrota, tend to progress into skin ulcer, and pathogenicity associated with PML-RARα-positive matured neutrophils. The etiology, pathogenesis, and risk factors of ATRA-associated scrotal ulceration were discussed in the literature review.

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“…It is considered as a reference method for molecular investigations in malignancies, prenatal diagnosis and microbial and parasitological diseases [72][73][74][75][76]. The method has been applied successfully to diagnose dermal malignant conditions such as melanomas, especially to discriminate ambiguous lesions [77][78][79][80]. It can be performed on formalin fixed, paraffin embedded (FFPE) tissues and requires less technical expertise as compared to other molecular cytogenetic methods such as comparative genomic hybridization [81].…”

Section: Fluorescence In Situ Hybridization Applications In Generalmentioning

confidence: 99%

Diagnosing Cutaneous leishmaniasis using Fluorescencein SituHybridization: the Sri Lankan Perspective

Kaluarachchi

Weerasekera

McBain

et al. 2019

Pathogens and Global Health

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Cutaneous leishmaniasis (CL) caused by Leishmania donovani MON-37 is becoming a major public health problem in Sri Lanka, with 100 new cases per month being reported in endemic regions. Diagnosis of CL is challenging for several reasons. Due to relative specificity and rapidity we propose Fluorescence in Situ Hybridization as a diagnostic tool for CL.The objective was to evaluate the potential of Fluorescence in Situ Hybridization as a diagnostic method for Cutaneous leishmaniasis in Sri Lanka.Literature on current laboratory tests used to diagnose Cutaneous leishmaniasis in Sri Lanka and globally was reviewed. Sri Lankan data were reviewed systematically following the PRISMA guidelines. A narrative of the results is presented.There is currently no gold standard diagnostic method for Cutaneous leishmaniasis. Fluorescence in Situ Hybridization has been previously applied to detect dermal pathologies including those involving infectious agents, and its use to detect the Leishmania parasite in human cutaneous lesions reported in small number of studies, generally with limited numbers of subjects. Advantages of FISH has been specificity, cost and ease-of-use compared to the alternatives.Based on the available literature and our current work, FISH has potential for diagnosing CL and should now be evaluated in larger cohorts in endemic regions. FISH for CL diagnosis could find application in countries such as Sri Lanka, where laboratory facilities may be limited in rural areas where the disease burden is highest.

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Fluorescence in situ hybridization investigation of cutaneous lesions in acute promyelocytic leukemia

Cited by 12 publications

References 25 publications

Dual effect of oxidative stress on leukemia cancer induction and treatment

Dual effect of oxidative stress on leukemia cancer induction and treatment

Distinct Characteristics of Sweet’s Syndrome of the Scrotum Caused by All-<b><i>trans</i></b> Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

Diagnosing Cutaneous leishmaniasis using Fluorescencein SituHybridization: the Sri Lankan Perspective

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